Results 51 to 60 of about 29,328 (191)

Induced fit, ensemble binding space docking and Monte Carlo simulations of MDMA ‘ecstasy’ and 3D pharmacophore design of MDMA derivatives on the human serotonin transporter (hSERT)

open access: yesHeliyon, 2021
The popular recreational drug MDMA (3,4-methylenedioxy-methamphetamine) has a documented potential as a psychopharmacological clinical and research tool.
Ángel A. Islas   +2 more
doaj  

Crystallographic Characterization of Sodium Ions in a Bacterial Leucine/Sodium Symporter

open access: yesCrystals, 2023
Na+ is the most abundant ion in living organisms and plays essential roles in regulating nutrient uptake, muscle contraction, and neurotransmission. The identification of Na+ in protein structures is crucial for gaining a deeper understanding of protein ...
Akira Karasawa   +4 more
doaj   +1 more source

Uptake of L-cystine via an ABC transporter contributes defense of oxidative stress in the L-cystine export-dependent manner in Escherichia coli. [PDF]

open access: yesPLoS ONE, 2015
Intracellular thiols like L-cystine and L-cystine play a critical role in the regulation of cellular processes. Here we show that Escherichia coli has two L-cystine transporters, the symporter YdjN and the ATP-binding cassette importer FliY-YecSC.
Iwao Ohtsu   +7 more
doaj   +1 more source

A role for the small GTPases RAC1 and RAC1b in the modulation of NIS expression: potentiation of therapy with radioactive iodine in differentiated thyroid carcinoma [PDF]

open access: yes, 2019
Introduction or Background: The Sodium Iodide Symporter (NIS) is responsible for active transport of iodide into thyroid follicular cells. The retention of its functional expression in most of the well-differentiated thyroid carcinomas (DTCs) enables ...
Bugalho, Maria J.   +5 more
core   +1 more source

ENDOCRINE TUMOURS: Imaging in the follow up of differentiated thyroid cancer: current evidence and future perspectives for a risk-adapted approach [PDF]

open access: yes, 2016
The clinical and epidemiological profiles of differentiated thyroid cancers (DTCs) have changed in the last three decades. Today's DTCs are more likely to be small, localized, asymptomatic papillary forms.
Deandreis, Désirée   +3 more
core   +1 more source

Combining Transfer of TTF-1 and Pax-8 Gene: a Potential Strategy to Promote Radioiodine Therapy of Thyroid Carcinoma [PDF]

open access: yes, 2011
Cotransfer of TTF-1 and Pax-8 gene to tumor cells, resulting in the reexpression of iodide metabolism-associated proteins, such as sodium iodide symporter (NIS), thyroglobulin (Tg), thyroperoxidase (TPO), offers the possibility of radioiodine therapy to ...
Anren Kuang   +4 more
core   +1 more source

Kinetic mechanism of coupled binding in sodium-aspartate symporter GltPh

open access: yeseLife, 2018
Many secondary active membrane transporters pump substrates against concentration gradients by coupling their uptake to symport of sodium ions. Symport requires the substrate and ions to be always transported together.
SeCheol Oh, Olga Boudker
doaj   +1 more source

Sodium iodide symporter (NIS) in extrathyroidal malignancies: Focus on breast and urological cancer [PDF]

open access: yes, 2014
BACKGROUND: Expression and function of sodium iodide symporter (NIS) is requisite for efficient iodide transport in thyrocytes, and its presence in cancer cells allows the use of radioiodine as a diagnostic and therapeutic tool in thyroid neoplasia ...
BIANCHI, Giampaolo   +8 more
core   +1 more source

Genome Analysis of a New Rhodothermaceae Strain Isolated from a Hot Spring

open access: yesFrontiers in Microbiology, 2016
A bacterial strain, designated RA, was isolated from water sample of a hot spring on Langkawi Island of Malaysia using marine agar. Strain RA is an aerophilic and thermophilic microorganism that grows optimally at 50–60°C and is capable of growing in ...
Kian Mau Goh   +7 more
doaj   +1 more source

Deteksi Natrium/Iodide Symporter (NIS) pada Galur Sel Kanker Payudara SKBR3 dengan Imunositofluoresens

open access: yesMajalah Kedokteran Bandung, 2016
SKBR-3 cell line is a breast cancer model for human epidermal growth factor receptor2 (HER2) positive. Only 50% of patients of this type have fully responded to chemotherapy.
Aisyah Elliyanti   +4 more
doaj  

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