Results 91 to 100 of about 3,788,125 (317)

Developing a fit-for-purpose composite symptom score as a symptom burden endpoint for clinical trials in patients with malignant pleural mesothelioma

Scientific Reports
We developed a composite symptom score (CSS) representing disease-related symptom burden over time in patients with malignant pleural mesothelioma (MPM).
Charles S. Cleeland, Karen N. Keating, Brian Cuffel, Cem Elbi, Jonathan M. Siegel, Christoph Gerlinger, Tara Symonds, Jeff A. Sloan, Amylou C. Dueck, Andrew Bottomley, Xin Shelley Wang, Loretta A. Williams, Tito R. Mendoza   +12 more
doaj   +1 more source

Digital twins to accelerate target identification and drug development for immune‐mediated disorders

FEBS Open Bio, EarlyView.
Digital twins integrate patient‐derived molecular and clinical data into personalised computational models that simulate disease mechanisms. They enable rapid identification and validation of therapeutic targets, prediction of drug responses, and prioritisation of candidate interventions.
Anna Niarakis, Philippe Moingeon
wiley   +1 more source

Patient‐Reported Outcomes for Patients With Metastatic NSCLC Treated at an Academic Medical Center, 2017–2021

Cancer Medicine
Background Understanding the symptom burden experienced by patients with cancer can enable appropriate supportive care. Our aim was to describe patient‐reported outcomes (PROs) for patients with metastatic NSCLC initiating first‐line (1L) systemic ...
Loretta A. Williams, Cai Xu, Darcy A. Ponce, Qiuling Shi, Melissa L. Santorelli, Thomas Burke, Mehmet Altan   +6 more
doaj   +1 more source

Recruitment and retention of clinical trial participants: understanding motivations of patients with chronic pain and other populations

Frontiers in Pain Research
This paper aims to present and discuss the issues, challenges, and strategies related to recruitment and retention in clinical trials involving participants with chronic pain.
Joyce K. Anastasi, Bernadette Capili, Margaret Norton, Margaret Norton, Donald J. McMahon, Karen Marder   +5 more
doaj   +1 more source

Systemic dysregulation of apolipoproteins in amyotrophic lateral sclerosis serum

FEBS Open Bio, EarlyView.
Amyotrophic lateral sclerosis (ALS) is a fatal disease that damages motor neurons. This study found that people with ALS show significant changes in blood fats and the proteins that carry them. Several apolipoproteins were higher, lipid balances were altered, and normal protein–lipid relationships were disrupted.
Finula I. Isik, Russell Pickford, Hannah C. Timmins, Olivier Piguet, Glenda M. Halliday, Matthew C. Kiernan, Woojin Scott Kim   +6 more
wiley   +1 more source

Nutritional Counseling During Chemotherapy Treatment: A Systematic Review of Feasibility, Safety, and Efficacy

Current Oncology
Dietary interventions during chemotherapy hold promise for clinical and supportive care outcomes. We systematically investigated the feasibility, safety, and efficacy of nutritional counseling conducted during chemotherapy.
Shalet James, Alexie Oppermann, Kaitlin M. Schotz, Mackenzie M. Minotti, Gautam G. Rao, Ian R. Kleckner, Brenton J. Baguley, Amber S. Kleckner   +7 more
doaj   +1 more source

Development of a Patient-Reported Symptom Item Bank for Patients with Hepatobiliary or Pancreatic Malignancies: A Systematic Review

Patient Preference and Adherence, 2023
Jingyu Zhang,1,* Yinxia Zhan,2,* Jiaojiao Chen,2 Dan Kang,2 Rumei Xiang,2 Ruoyi Zhang,2 Yubo Zhang,1 Yang Pu,2 Jiayuan Zhang,1 Lijun Zhang,2 Yanyan Huang,2 Ruoyan Gong,2 Xueyao Su,2 Yuxian Nie,1 Qiuling Shi1,2 1State Key Laboratory of Ultrasound ...
Zhang J, Zhan Y, Chen J, Kang D, Xiang R, Zhang R, Zhang Y, Pu Y, Zhang J, Zhang L, Huang Y, Gong R, Su X, Nie Y, Shi Q   +14 more
doaj  

Symptom prescription [PDF]

British Dental Journal, 2013
Sharath, Asokan, Geetha, Priya Pr
openaire   +2 more sources

Natural Products as Geroprotective Modulators in Diabetic Nephropathy: A Mechanistic Framework Integrating Aging Hallmarks and the AMPK–SIRT1–Nrf2 Axis

Aging and Cancer, EarlyView.
Natural products target the aging kidney in diabetic nephropathy by restoring the AMPK–SIRT1–Nrf2 axis, reducing oxidative stress, inflammation, fibrosis, and cellular senescence while enhancing mitochondrial biogenesis and antioxidant defenses.
Sherif Hamidu, Latif Adams, Eunice Ampem‐Danso, Justice Kumi, Abigail Aning, Fatima Hamidu, Mustapha Abdul Mumin Mohammed, Ayuba Nii Darku Ankrah, Seth Kwabena Amponsah   +8 more
wiley   +1 more source

Context-dependent placebo hypoalgesia through observational learning: the role of empathy in immersive and non-immersive environments

npj Digital Medicine
Digital environments are increasingly used to study social and pain-related behaviors. Empathy and contextual factors influence observationally induced placebo analgesia.
Jewel N. White, Lakota Watson, Yang Wang, Giancarlo Colloca, Jonathan Michael Heagerty, Sida Li, Barbara Brawn, Amitabh Varshney, Roni Shafir, Carmen-Édith Belleï-Rodriguez, Luana Colloca   +10 more
doaj   +1 more source