Results 71 to 80 of about 1,402,226 (290)

Memory and Resting‐State Connectivity in Acute Transient Global Amnesia: A Case–Control fMRI Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background and Objectives Transient global amnesia (TGA) is a striking model of isolated amnesia. While hippocampal lesions are well described, the network‐level mechanisms and the precise neuropsychological profile remain debated. Our objective was thus to characterize functional and neuropsychological correlates of acute TGA and their ...
Elias El Otmani, Emmanuel Barbeau, Béatrice Lemesle, Emilie Milongo‐Rigal, Sophie Fernandez, Sandrine Charpentier, Jean‐François Albucher, Nicolas Raposo, Fabrice Bonneville, Patrice Péran, Jérémie Pariente   +10 more
wiley   +1 more source

Prodromal Lewy Body Disorder Features in REM Sleep Behavior Disorder With Biomarker‐Defined Synucleinopathy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Isolated rapid eye movement sleep behavior disorder (iRBD) is a prodromal state for Lewy body disorders and exhibits biological heterogeneity that may influence clinical expression and progression. We examined clinical features in individuals with iRBD and biomarker‐defined synucleinopathy.
Daniel Weintraub, Michele K. York, Roseanne Dobkin, Anuprita R. Nair, Ryan Kurth, David‐Erick Lafontant, Chelsea Caspell‐Garcia, Roy N. Alcalay, Ethan G. Brown, Lana M. Chahine, Christopher Coffey, Tatiana Foroud, Douglas Galasko, Karl Kieburtz, Kenneth Marek, Kalpana Merchant, Brit Mollenhauer, Kathleen L. Poston, Andrew Siderowf, Cristina Simonet, Tanya Simuni, Caroline M. Tanner, Thomas F. Tropea, Aleksandar Videnovic, The Parkinson's Progression Markers Initiative   +24 more
wiley   +1 more source

Exploring core and sentinel symptoms in elderly patients with type 2 diabetes through network analysis and the Apriori algorithm

Frontiers in Medicine
ObjectiveTo construct the symptom network of elderly patients with type 2 diabetes mellitus (T2DM) and perform association rule analysis for each symptom cluster, identify core symptoms, and explore the sentinel symptoms, to provide references for ...
Tingting Tan, Tingting Tan, Chongyao Yang, Qingqing Wang, Qingqing Wang, Cong Xu, Cong Xu, Sijing Wang, Bingbing Xiao, Bingbing Xiao, Jing Zhao, Jing Zhao, Huan He, Miaoqin Wang   +13 more
doaj   +1 more source

Early Clinical, Imaging, and Pathological Characteristics of SRPK3/TTN‐Digenic Myopathy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective SRPK3/TTN‐digenic myopathy was recently established as a skeletal muscle myopathy caused by digenic inheritance. This study characterizes the early clinical presentation of SRPK3/TTN‐digenic myopathy in one previously reported and seven newly identified pediatric patients.
Rotem Orbach, Sandra Donkervoort, Carola Hedberg‐Oldfors, Giovanni Baranello, Dimah Saade, Precilla D'Souza, Ruchee Patel, Eva Michael, A. Reghan Foley, Diana Bharucha‐Goebel, S. Jin Haugland, Meghan McAnally, Omer Abdul Hamid, Katherine Chao, Ellen F. Macnamara, Alan H. Beggs, Anna Sarkozy, Juliane Mueller, Steven A. Moore, Richard S. Finkel, Cynthia J. Tifft, Francesco Muntoni, Anders Oldfors, Carsten G. Bönnemann   +23 more
wiley   +1 more source

A structural equation modeling framework for estimating symptom burden based on symptom clusters in cancer survivors

Scientific Reports
Symptoms after cancer and its treatment challenge the well-being of cancer survivors. Little is known about symptom co-occurrence and the burden experienced by cancer survivors.
Anne Katrine Graudal Levinsen, Anders Tolver, Trille Kristina Kjaer, Lau Caspar Thygesen, Jan Wohlfahrt, Susanne Rosthøj, Lærke Kjær Tolstrup, Marianne Nord Hansen, Simone Oerlemans, Christine Miaskowski, Peer Christiansen, Peter Christensen, Christoffer Johansen, Robert Zachariae, Lena Saltbæk, Susanne Oksbjerg Dalton   +15 more
doaj   +1 more source

Comparative Effectiveness and Safety of Inebilizumab Versus Rituximab in AQP4‐IgG‐Positive NMOSD

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Rituximab (anti‐CD20, RTX) and inebilizumab (anti‐CD19, INE) represent B‐cell‐depleting therapies used for aquaporin‐4 antibody‐positive (AQP4‐IgG+) neuromyelitis optica spectrum disorder (NMOSD); however, direct comparative evidence remains limited.
Jie Lin, Binbin Xue, Dewei Xie, Jia Li, Juyuan Pan, Lanbing Zhu, Qiaowen Tong, Jing Lin, Ruofan Zhu, Xu Zhang, Junhui Xia, Xiang Li   +11 more
wiley   +1 more source

Management of the respiratory distress symptom cluster in lung cancer: a randomised controlled feasibility trial [PDF]

, 2015
Background: Breathlessness, cough and fatigue are distressing symptoms for patients with lung cancer. There is evidence that these three symptoms form a discreet symptom cluster. This study aimed to feasibility test a new non-pharmacological intervention
Fiona Blackhall, Luker, K, Karen Luker, Pilling, M., Luker, Karen; id_orcid, Smith, Jacky; id_orcid, Bailey, Chris, Pillling, Mark, Janelle Yorke, Mari Lloyd-Williams, Yorke, Janelle, Ellis, J, Ellis, J., Smith, Jacky, Molasiotis, A., Jackie Ellis, Jacky Smith, Molassiotis, Alex, Luker, Karen, Harle, A., Blackhall, Fiona; id_orcid, Pilling, Mark, Lloyd-Williams, M, Yorke, J., Smith, J., Lloyd-Williams, Mari, Warden, J., Molassiotis, Alexander, Haines, J, Lloyd-Williams, M., Smith, J, Ellis, Jackie, Blackhall, F., Pilling, M, Amelie Harle, Haines, J., Harle, Amelie, Blackhall, Fiona, Warden, June, Alex Molassiotis, Luker, K., Warden, J, June Warden, Mark Pilling, Haines, Jemma, Jemma Haines, Blackhall, Fiona H, Molassiotis, A, Harle, Amelie S   +48 more
core   +2 more sources

Unraveling 4‐Phenylbutyrate's Therapeutic Role in SLC6A1 Disorders: Pharmacochaperoning Over HDAC Inhibition

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Variants in SLC6A1, encoding the GABA transporter 1 (GAT‐1), cause epilepsy, autism spectrum disorder, and developmental delay via loss of GABA uptake, impaired trafficking, and ER retention. We previously found that 4‐Phenylbutyrate (PBA), an FDA‐approved drug, restores GABA uptake and reduces seizures in SLC6A1‐related disorders ...
Melissa B. DeLeeuw, Karishma Randhave, Ekta Anand, Ziang (Debbie) Song, Wangzhen Shen, Jing‐Qiong Kang   +5 more
wiley   +1 more source

Symptom clustering in chronic gastritis based on spectral clustering

Journal of Traditional Chinese Medicine, 2014
Apply spectral clustering to analyze the patterns of symptoms in patients with chronic gastritis (CG).Based on 919 CG subjects, we applied mutual information feature selection to choose the positively correlated symptoms with each pattern. Then, we used the Shi and Malik spectral clustering algorithm to select the top 20 correlated symptoms.We ...
Zhu, Wenhua, Fan, Zhaoxiang, Liu, Guoping, Yan, Jianjun, Zhong, Tao, Zheng, Wu, Wang, Ruiqing, Wang, Chunying   +7 more
openaire   +2 more sources

Sex‐Stratified Association of Regional Dopamine Transporter Binding With Disease Progression in Amyotrophic Lateral Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To clarify the clinical relevance of dopamine transporter single‐photon emission computed tomography (DAT‐SPECT) abnormalities in amyotrophic lateral sclerosis (ALS), with a prespecified focus on sex‐stratified associations with disease progression and short‐term prognosis.
Tomoya Kawazoe, Keizo Sugaya, Kentaro Hayashi, Keiko Hino, Yasuhiro Nakata, Kota Bokuda, Toshio Shimizu, Kazushi Takahashi   +7 more
wiley   +1 more source