Results 111 to 120 of about 6,338,781 (311)

Identification of serum protein biomarkers for pre‐cancerous lesions associated with pancreatic ductal adenocarcinoma

Molecular Oncology, EarlyView.
This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns, Jaclyn S. Long, Sergio Lilla, Kelly Hodge, Marcus J. G. W. Ladds, Colin Nixon, Paula Fernández‐Palanca, Sara Zanivan, Pilar Acedo, Stephen P. Pereira, Kevin M. Ryan   +10 more
wiley   +1 more source

Is prostatic artery embolization a relevant treatment after a failed alpha-blocker monotherapy?

The Lancet Regional Health. Europe, 2023
Souhil Lebdai
doaj   +1 more source

Relato da vida escolar de pessoas com o transtorno obsessivo-compulsivo e altas habilidades: a necessidade de programas de enriquecimento School life of people who have obsessive-compulsive disorder and high habilities: the need of enrichment programs

Revista Brasileira de Educação Especial, 2005
Este artigo tem por objetivo discutir a oferta de atividades escolares de apoio a estudantes com sintomas ou transtorno obsessivo-compulsivo e altas habilidades/superdotação/talentos, através de atividades psico-educacionais denominadas programas de ...
Maria Claudia Dutra Lopes Barbosa, Luci Gelabert Simonetti, Mary Rangel   +2 more
doaj   +1 more source

The power to resist: the relationship between power, stigma, and negative symptoms in schizophrenia. [PDF]

, 2014
Stigmatizing beliefs about mental illness can be a daily struggle for people with schizophrenia. While investigations into the impact of internalizing stigma on negative symptoms have yielded mixed results, resistance to stigmatizing beliefs has received
Campellone, Timothy R, Caponigro, Janelle M, Kring, Ann M   +2 more
core  

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Clinical profile during the first and second pandemic waves in children and adolescents with COVID-19 at pediatric public hospital, Rio de Janeiro, Brazil

Microbes, Infection and Chemotherapy
Background: COVID-19 is usually milder in children and adolescents, leading to lower hospital admission rates than adults. This study evaluated clinical manifestations in children (< 10 years) and adolescents (10 to < 18 years) with COVID-19 admitted to
Jeferson Tobias da Silva de Oliveira de Oliveira, Luciana Fernandes Portela, Marcelo Carvalho Vieira, Mariana Cristina Mendes Almeida, Luiz Henrique Conde Sangenis, Ivonete Siviero, Tatiana Rehder Gonçalves, Mauro Mediano   +7 more
doaj   +1 more source

Alcohol‐induced altered glycans in human tracheal epithelial cells promote bacterial adhesion

FEBS Open Bio, EarlyView.
Alcohol induces altered glycans to promote bacteria adhesion. Heavy alcohol drinking is known to increase the risk of bacterial pneumonia. However, the link between alcohol levels and risk of infection remains underexplored. Recently, we found that alcohol induced α2‐6sialo mucin O‐glycans in human tracheobronchial epithelial cells, which mediated the ...
Pi‐Wan Cheng, Souvik Datta, Derrick R. Samuelson   +2 more
wiley   +1 more source

Menstrual cycle tracking in professional volleyball athletes

Frontiers in Sports and Active Living
IntroductionThe menstrual cycle may affect well-being and physical performance of elite female athletes by interfering with the function of multiple physiological systems.
Andrea Roffler, Marie-Therese Fleddermann, Hanna de Haan, Karsten Krüger, Karen Zentgraf   +4 more
doaj   +1 more source