Results 91 to 100 of about 4,332,955 (318)

COVID-19 challenge for modern medicine

Cardiology Journal, 2020
Coronaviruses cause disease in animals and people around the world. Human coronaviruses (HCoV) are mainly known to cause infections of the upper and lower respiratory tract but the symptoms may also involve the nervous and digestive systems.
Tomasz Dzieciatkowski, Lukasz Szarpak, Krzysztof J. Filipiak, Milosz Jaguszewski, Jerzy R. Ladny, Jacek Smereka   +5 more
doaj   +1 more source

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

Clinical diagnosis and computer analysis of headache symptoms

, 1984
The headache histories obtained from clinical interviews of 600 patients were analysed by computer to see whether patients could be separated systematically into clinical categories and to see whether sets of symptoms commonly reported together differed ...
Drummond, P.D., Lance, J.W.
core  

SIPS - Screening-Instrument für prämenstruelle Symptome : Die deutsche Version des Premenstrual Symptoms Screening Tool zur Erfassung klinisch relevanter Beschwerden [PDF]

, 2011
Premenstrual Dysphoric Disorder (PMDD) and severe Premenstrual Syndrome (PMS) are common, yet often remain unrecognized and not adequately treated. One reason for this is the lack of a valid German screening instrument.
D. Bentz, Steiner, M., Meinlschmidt, G., G. Meinlschmidt, M. Steiner, Bentz, D.   +5 more
core   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

GASTROINTESTINAL SYMPTOMS IN INFANCY: A POPULATION-BASED PROSPECTIVE STUDY

, 2005
BACKGROUND: During the first months of life, infants can suffer from many 'minor' gastroenterological disturbances. However, little is known about the frequency of these problems and the factors which predispose or facilitate their onset. AIMS: (a) To
INDINNIMEO, L, D. D’Amico, AVERNA, Maurizio, R. Merolla, L. Di Prima, D'AMICO, D, L. Indinnimeo, G. Iacono, A. Carroccio, CARROCCIO, Antonio, SCALICI, C, IACONO, G, MEROLLA, R, CAVATAIO, Francesca, M.R. Averna, DI PRIMA, Lidia, BONCI, Enea, F. Cavataio, INDINNIMEO, Luciana, M. R. Averna, BONCI, E, E. Bonci, C. Scalici, I. N. Infancy The Paediatric Study Group On Gastrointestinal Symptoms, D. D'Amico   +24 more
core   +1 more source

Characterization of COVID-19 cases in the formal and informal settlements in Dagoretti sub-county Kenya, 2020

Journal of Interventional Epidemiology and Public Health
Introduction: COVID-19 posed a serious public health threat to all ages. In Kenya, it was first detected on March 13, 2020, in its capital - Nairobi, which remained the epicenter of the disease thereafter. Dagoretti is one area that has both formal and
Florence Wanjiru Mugo, Ahmed Abade Mohamed, Peter Kabetu Njenga, Maurice Owiny, Fredrick Odhiambo   +4 more
doaj   +1 more source

Liquid biopsy‐based diagnostic evaluation of hypermethylated CpG sites for ovarian cancer diagnosis

Molecular Oncology, EarlyView.
This schematic outlines the workflow from biomarker identification to duplex MethyLight assay validation for epithelial ovarian cancer diagnosis using cfDNA‐based liquid biopsy. Initial screening of hypermethylated CpG candidates (cg02957270, cg10061138 cg00480298, COL2A1) was performed in tissue using ARMS‐PCR, COBRA, qPCR and image analysis. Selected
Deepa Bisht, Sameer Gupta, Amrita Chaurasia, Manisha Sachan   +3 more
wiley   +1 more source

Duration of the Symptoms and Brain Aging in Women with Fibromyalgia: A Cross-Sectional Study

Applied Sciences, 2019
Fibromyalgia is a chronic syndrome that is characterized by widespread pain and an altered brain dynamic. The aim of this study was to analyze the effect of the duration of the symptoms on the cortical activity of women with fibromyalgia using ...
Santos Villafaina, Daniel Collado-Mateo, Juan P. Fuentes-García, Francisco J. Domínguez-Muñoz, Narcís Gusi   +4 more
doaj   +1 more source

Systemic dysregulation of apolipoproteins in amyotrophic lateral sclerosis serum

FEBS Open Bio, EarlyView.
Amyotrophic lateral sclerosis (ALS) is a fatal disease that damages motor neurons. This study found that people with ALS show significant changes in blood fats and the proteins that carry them. Several apolipoproteins were higher, lipid balances were altered, and normal protein–lipid relationships were disrupted.
Finula I. Isik, Russell Pickford, Hannah C. Timmins, Olivier Piguet, Glenda M. Halliday, Matthew C. Kiernan, Woojin Scott Kim   +6 more
wiley   +1 more source