Results 131 to 140 of about 531,184 (380)

A Spatially Resolved View on the Aging Substantia nigra: An Exploratory Proteomic Study

Advanced Biology, EarlyView.
Although aging is the most important risk factor for several neurodegenerative diseases, the molecular effects of physiological aging are still understudied. By applying spatially‐resolved proteomic analyses of the human substantia nigra pars compacta, alterations in vesicular trafficking and mitochondrial proteins are observed, as well as reduced ...
Britta Eggers, Maximilian Hausherr, Michel Lim, Karin Schork, Bilhan Karacora, Robin Grugel, Martin Eisenacher, Isabel Gil Aldea, Peter Riederer, Manfred Gerlach, Katrin Marcus   +10 more
wiley   +1 more source

Clustered synapses develop in distinct dendritic domains in visual cortex before eye opening

eLife
Synaptic inputs to cortical neurons are highly structured in adult sensory systems, such that neighboring synapses along dendrites are activated by similar stimuli.
Alexandra H Leighton, Juliette E Cheyne, Christian Lohmann   +2 more
doaj   +1 more source

Natural Oligomers of the Alzheimer Amyloid-β Protein Induce Reversible Synapse Loss by Modulating an NMDA-Type Glutamate Receptor-Dependent Signaling Pathway

Journal of Neuroscience, 2007
Alzheimer's disease (AD) is characterized by decreased synapse density in hippocampus and neocortex, and synapse loss is the strongest anatomical correlate of the degree of clinical impairment.
G. Shankar, Brenda L. Bloodgood, Matthew Townsend, D. Walsh, D. Selkoe, B. Sabatini   +5 more
semanticscholar   +1 more source

All‐in‐One Analog AI Hardware: On‐Chip Training and Inference with Conductive‐Metal‐Oxide/HfOx ReRAM Devices

Advanced Functional Materials, EarlyView.
An all‐in‐one analog AI accelerator is presented, enabling on‐chip training, weight retention, and long‐term inference acceleration. It leverages a BEOL‐integrated CMO/HfOx ReRAM array with low‐voltage operation (<1.5 V), multi‐bit capability over 32 states, low programming noise (10 nS), and near‐ideal weight transfer.
Donato Francesco Falcone, Victoria Clerico, Wooseok Choi, Tommaso Stecconi, Folkert Horst, Laura Bégon‐Lours, Matteo Galetta, Antonio La Porta, Nikhil Garg, Fabien Alibart, Bert Jan Offrein, Valeria Bragaglia   +11 more
wiley   +1 more source

Membrane-Proximal Epitope Facilitates Efficient T Cell Synapse Formation by Anti-FcRH5/CD3 and Is a Requirement for Myeloma Cell Killing [PDF]

, 2017
Ji Li, Nicola J. Stagg, Jennifer Johnston, Michael J. Harris, Sam A. Menzies, Danielle DiCara, Vanessa Clark, Maria Hristopoulos, Ryan Cook, Dionysos Slaga, Rin Nakamura, McCarty Luke, Siddharth Sukumaran, Elizabeth Luis, Zhengmao Ye, Thomas D. Wu, Teiko Sumiyoshi, Dimitry M. Danilenko, Genee Y. Lee, Klára Tótpál, Diego Ellerman, Isidro Hötzel, John R. James, Teemu T. Junttila   +23 more
openalex   +1 more source

Symmetry Enhanced Unconventional Spin Current Anisotropy in a Collinear Antiferromagnet

Advanced Functional Materials, EarlyView.
Spin‐orbit torques (SOTs) are investigated in epitaxial FeSn, a topological antiferromagnet with kagome lattice symmetry. Combining experimental and theoretical approaches, the study identifies a six‐fold conventional damping‐like spin‐orbit torque (DL SOT), along with the coexistence of both six‐fold and uniaxial unconventional field‐like torque (FL ...
Pankhuri Gupta, Kacho Imtiyaz Ali Khan, Akash Kumar, Pratik Sahu, Rekha Agarwal, Artem Litvinenko, Nidhi Kandwal, Ram Singh Yadav, Birabar Ranjit Kumar Nanda, Johan Åkerman, Pranaba Kishor Muduli   +10 more
wiley   +1 more source

Characterisation of the Volatile Compounds and Key Odourants in Japanese Mandarins by Gas Chromatography–Mass Spectrometry and Gas Chromatography–Olfactometry

Separations
Japanese mandarins are becoming increasingly popular due to their pleasant aroma. The volatiles in four varieties of Japanese mandarins (Iyokan, Ponkan, Shiranui, and Unshiu mikan) were extracted by headspace solid-phase microextraction (HS-SPME) and ...
Lingyi Li, Rui Min Vivian Goh, Yunle Huang, Kim-Huey Ee, Aileen Pua, Daphne Tan, Shanbo Zhang, Lionel Jublot, Shao Quan Liu, Bin Yu   +9 more
doaj   +1 more source

Synaptic partner prediction from point annotations in insect brains

, 2018
High-throughput electron microscopy allows recording of lar- ge stacks of neural tissue with sufficient resolution to extract the wiring diagram of the underlying neural network.
A Kreshuk, A Kreshuk, A Kreshuk, B Staffler, C Becker, N Kasthuri, O Ronneberger, S Dorkenwald, V Jagadeesh   +8 more
core   +1 more source

Adaptive synapse-based neuron model with heterogeneous multistability and riddled basins [PDF]

, 2022
Han Bao, Jing Zhang, Ning Wang, Н. В. Кузнецов, Bocheng Bao   +4 more
openalex   +1 more source

Biomaterial Strategies for Targeted Intracellular Delivery to Phagocytes

Advanced Functional Materials, EarlyView.
Phagocytes are essential to a functional immune system, and their behavior defines disease outcomes. Engineered particles offer a strategic opportunity to target phagocytes, harnessing inflammatory modulation in disease. By tuning features like size, shape, and surface, these systems can modulate immune responses and improve targeted treatment for a ...
Kaitlyn E. Woodworth, Neal I. Callaghan, Locke Davenport Huyer   +2 more
wiley   +1 more source