Results 191 to 199 of about 37,262 (199)

Wnt Inhibition Safeguards Porcine Embryonic Stem Cells From the Acquisition of Extraembryonic Endoderm Cell Fates

Advanced Science, EarlyView.
The study reports that Wnt inhibitors safeguard porcine embryonic stem cells (ESCs) from acquiring the extraembryonic endoderm (XEN) lineage, and further develop an efficient strategy to derive XEN cells from ESCs. The XEN cells from ESCs exhibit similar transcriptome and chromatin accessibility features to XEN cells from embryos and contribute to ...
Hanning Wang, Liang Zhong, Zhuangfei Wang, Jinzhu Xiang, Duanqing Pei   +4 more
wiley   +1 more source

Chromosome‐Level Genome Assembly of the Leafcutter Bee Megachile rotundata Reveals Its Ecological Adaptation and Pollination Biology

Advanced Science, EarlyView.
The genome of Megachile rotundata, an extensively managed solitary pollination bee species, has been sequenced, covering 280.68 Mb and predicting 10 701 genes. The study reveals significant expansions of the Toll gene family and their abundant expression in diapause prepupae, highlighting enhanced immune responses during diapause. This genome serves as
Rangjun Shi, Pan Duan, Mengmeng Zhu, Rong Zhang, Zihua Zhao, Xin Nie, Hanhou He, Li Hou, Xianhui Wang   +8 more
wiley   +1 more source

ALKBH3‐Mediated M1A Demethylation of METTL3 Endows Pathological Fibrosis:Interplay Between M1A and M6A RNA Methylation

Advanced Science, EarlyView.
RNA modification is crucial in fibrosis diseases, but the role of m1A modification remains elusive. This study reveals that ALKBH3, an m1A demethylase, drives skin fibrosis by reshaping m6A RNA modification and stabilizing COL1A1 and FN1 mRNAs through METTL3, uncovering a crosstalk between m1A and m6A methylation in pathological events.
Liying Tu, Shuchen Gu, Ruoqing Xu, En Yang, Xin Huang, Hsin Liang, Shenying Luo, Haizhou Li, Yixuan Zhao, Tao Zan   +9 more
wiley   +1 more source

Regulation of PVT‐CeA Circuit in Deoxynivalenol‐Induced Anorexia and Aversive‐Like Emotions

Advanced Science, EarlyView.
The study investigates Deoxynivalenol (DON) effects on feeding and emotions, focusing on the central amygdala (CeA). Acute DON exposure reduces food intake and alters behavior, linked to CeAGABA neuron activity and PVT‐CeA connectivity. Manipulating CeAGABA neurons and using SCN10A antagonist A‐803467 alleviate DON's effects, offering potential ...
Liu‐Nan Yang, Mingmeng Tang, Andreas K. Nüssler, Liegang Liu, Wei Yang   +4 more
wiley   +1 more source

Photo‐Biomodulation of the Hippocampus Using Near‐Infrared Laser to Enhance Cognitive Function in Mice

Advanced Science, EarlyView.
Here a transcranial photo‐biomodulation approach is developed using near‐infrared (NIR) laser on hippocampus of mice, revealing significant improvements in learning and memory ability of mice under normal and disease conditions. The improvement results from the high‐density cell‐induced NIR local energy deposition, neuronal activation, and axonogenesis
Wei‐Tong Pan, Han‐Wen Gu, Yan‐Bo Zhou, Sophie Ma, Daqing Ma, Pan‐Miao Liu, Jian‐Jun Yang   +6 more
wiley   +1 more source

Bioinspired Adaptive Neuron Enabled by Self‐powered Optoelectronic Memristor and Threshold Switching Memory for Neuromorphic Visual System

Advanced Science, EarlyView.
The self‐powered optoelectronic memristor based on ZnO/WOx heterojunction is developed, exhibiting the visual adaptation functions of desensitization and Weber's law. A bioinspired visual adaptive neuron is constructed, capable of converting light stimuli into dynamic spike trains.
Yankun Cheng, Junchao Zhang, Ya Lin, Zhongqiang Wang, Xuanyu Shan, Ye Tao, Xiaoning Zhao, Haiyang Xu, Yichun Liu   +8 more
wiley   +1 more source

Neuromorphic Computing Using Synaptic Plasticity of Supercapacitors

Advanced Science, EarlyView.
A neuromorphic computing pathway based on supercapacitors is presented. MXene Ti₃C₂Tx supercapacitors demonstrate voltage responses under current stimuli, thus exhibiting synaptic plasticity. Energy is stored during response enhancement and released once the response declines.
Ling Wang, Xing Liu, Guangcai Zhang, Fuxun Qi, Xi Chen   +4 more
wiley   +1 more source

High‐Performance Synapse Arrays for Neuromorphic Computing via Floating Gate‐Engineered IGZO Synaptic Transistors

Advanced Science, EarlyView.
Indium‐gallium‐zinc oxide synaptic transistors are introduced utilizing an indium‐tin oxide (ITO) floating gate (FG). The ITO FG's higher conductivity and alleviated chemical interactions with the Al2O3 tunneling layer contribute to enhanced performance.
Junhyeong Park, Yumin Yun, Sunyeol Bae, Yuseong Jang, Seungyoon Shin, Soo‐Yeon Lee   +5 more
wiley   +1 more source

Utilizing Caenorhabditis Elegans as a Rapid and Precise Model for Assessing Amphetamine‐Type Stimulants: A Novel Approach to Evaluating New Psychoactive Substances Activity and Mechanisms

Advanced Science, EarlyView.
This study uses Caenorhabditis elegans to assess the activity of amphetamine‐type stimulants (ATS) and their analogs. The research highlights the roles of dopamine and serotonin pathways, distinguishes chiral forms of ATS, and identifies structure‐activity relationships. These findings provide a rapid and cost‐effective model for evaluating the effects
Yuanpeng Li, Hongyuan Li, Hongshuang Wang, Xiaohui Wang   +3 more
wiley   +1 more source