Results 311 to 320 of about 421,951 (351)
Some of the next articles are maybe not open access.
European Journal of Neuroscience, 2014
AbstractIt has been several decades since synaptic dysfunction was first suggested to play a role in schizophrenia, but only in the last few years has convincing evidence been obtained as progress has been made in elucidating the genetic underpinnings of the disorder.
Michael Conlon O'Donovan +2 more
openaire +3 more sources
AbstractIt has been several decades since synaptic dysfunction was first suggested to play a role in schizophrenia, but only in the last few years has convincing evidence been obtained as progress has been made in elucidating the genetic underpinnings of the disorder.
Michael Conlon O'Donovan +2 more
openaire +3 more sources
Nature Reviews Neuroscience, 2002
Post-translational modification by the attachment of ubiquitin seems to have a crucial role in regulating synaptic structure and function. By controlling the stability, activity and localization of target proteins, this versatile regulatory system can shape the pattern, activity and plasticity of synaptic connections.
Ashok N. Hegde, Aaron DiAntonio
openaire +3 more sources
Post-translational modification by the attachment of ubiquitin seems to have a crucial role in regulating synaptic structure and function. By controlling the stability, activity and localization of target proteins, this versatile regulatory system can shape the pattern, activity and plasticity of synaptic connections.
Ashok N. Hegde, Aaron DiAntonio
openaire +3 more sources
Nature Methods, 2014 A combination of experimental protein analysis and imaging techniques is used to create a three-dimensional model of a synaptic bouton.
openaire +2 more sources
Molecular Immunology, 2002
The immunological synapse plays a central role in organising the immune system. Through their synaptic activity both T and B cells usually, but not always, acquire the information that critically determines the level and nature of the responses that they make. For T cells much of that information comes from epicrine and paracrine cell-cell interactions
N.M. Terazzini +2 more
openaire +3 more sources
The immunological synapse plays a central role in organising the immune system. Through their synaptic activity both T and B cells usually, but not always, acquire the information that critically determines the level and nature of the responses that they make. For T cells much of that information comes from epicrine and paracrine cell-cell interactions
N.M. Terazzini +2 more
openaire +3 more sources
Proteolytic activity, synapse elimination, and the Hebb synapse
Journal of Neurobiology, 1994AbstractThe Hebb synapse has been postulated to serve as a mechanism subserving both regulation of synaptic strength in the adult nervous system (long‐term potentiation and depression) and developmental activity‐dependent plasticity. According to this model, pre‐ and postsynaptic temporal concordance of activity results in strengthening of connections,
Fields Rd +4 more
openaire +3 more sources
Nature Reviews Neuroscience, 2009
MicroRNAs (miRNAs) are emerging as key modulators of post-transcriptional gene regulation in a plethora of tissues, including the nervous system. Recent evidence points to a widespread role for neural miRNAs at various stages of synaptic development, including dendritogenesis, synapse formation and synapse maturation.
openaire +3 more sources
MicroRNAs (miRNAs) are emerging as key modulators of post-transcriptional gene regulation in a plethora of tissues, including the nervous system. Recent evidence points to a widespread role for neural miRNAs at various stages of synaptic development, including dendritogenesis, synapse formation and synapse maturation.
openaire +3 more sources
Progress in Neurobiology, 1997
Thalamocortical synapses inform the cerebral neocortex about the external and internal worlds. The thalamus produces myriad thalamocortical pathways that vary in morphological, physiological, pharmacological and functional properties. All these features are of great importance for understanding how information is acquired, integrated, processed, stored
M A, Castro-Alamancos, B W, Connors
openaire +2 more sources
Thalamocortical synapses inform the cerebral neocortex about the external and internal worlds. The thalamus produces myriad thalamocortical pathways that vary in morphological, physiological, pharmacological and functional properties. All these features are of great importance for understanding how information is acquired, integrated, processed, stored
M A, Castro-Alamancos, B W, Connors
openaire +2 more sources
Brain Structure and Function, 2017
It has long been held that the rise of neurons as a specialized cell type also marked the onset of the grand evolutionary journey for chemical synapses. Research over recent decades has shown, however, that the most dynamic chapters of synaptic history have been 'written' out of the context of neurobiology and neuronal evolution, dating back to the ...
openaire +3 more sources
It has long been held that the rise of neurons as a specialized cell type also marked the onset of the grand evolutionary journey for chemical synapses. Research over recent decades has shown, however, that the most dynamic chapters of synaptic history have been 'written' out of the context of neurobiology and neuronal evolution, dating back to the ...
openaire +3 more sources
Synapse selection based on differences in synapse turnover
International Journal of Developmental Neuroscience, 1983AbstractRat retinal neurons formed transient synapses with rat muscle cells in culture only during a discrete period in development, from the 20th day of embryonic development to the 7th neonatal day. In contrast, chick embryo spinal cord neurons formed synapses at all developmental stages tested, from the 2nd to the 18th day of embryonic development ...
Jeffrey M. Thompson +3 more
openaire +2 more sources
Synapse elimination, the size principle, and Hebbian synapses
Journal of Neurobiology, 1995AbstractSynapse elimination at the vertebrate neuromuscular junction reduces a polyinnervated population of muscle fibers to a monoinnervated state. The function of this developmental phenomenon (if any) is unproven. A theoretical analysis of Hebbian (correlation) rules connecting presynaptic and postsynaptic activity and synaptic strength at the ...
openaire +3 more sources