Results 251 to 260 of about 471,836 (383)

Extracellular vesicles derived from human Wharton’s jelly mesenchymal stem cells protect hippocampal neurons from oxidative stress and synapse damage induced by amyloid-β oligomers

, 2019
Victor Bodart‐Santos, Luiza Carvalho, Mariana Araya de Godoy, André F. Batista, Leonardo Saraiva, Luize G. Lima, Carla Andreia Abreu, Fernanda G. De Felice, Antônio Galina, Rosalia Méndez‐Otero, Sérgio T. Ferreira   +10 more
openalex   +1 more source

Islet Amyloid Polypeptide Modelled to Simulate Diabetes Co‐Oligomerized with β‐Amyloid 1‐42 Reproducing the Pathological Cascade of Alzheimer's Disease in Human Cerebral Organoids

Advanced Science, EarlyView.
Human islet amyloid polypeptide (hIAPP) was used to mimic T2DM, and Aβ42‐hIAPP co‐oligomers were delivered into the human mature cerebral organoids (COs), which reproduce typical AD pathology and significant neuronal death more closely resembling that of AD patients.
Jin Yan, Zhimeng Tang, Yanyu Luo, Bin Liu, Xinxin Huang, Jun Wei, Feng Yue   +6 more
wiley   +1 more source

Mechanical Overloading‐Induced Nanomineral Crystal Perturbation from the Osteochondral Interface: A Potential Initiator of Osteoarthritis

Advanced Science, EarlyView.
Laser‐induced graphene (LIG) provides a scalable, laser‐direct‐written route to porous graphene architecture with tunable chemistry and defect density. Through heterojunction engineering, catalytic functionalization, and intrinsic self‐heating, LIG achieves highly sensitive and selective detection of NOX, NH3, H2, and humidity, supporting next ...
Nan Jiang, Rong Ren, Zhan Su, Jiahao Zhou, Pinyin Cao, Sicheng Zhang, Zhen Li, Chao Li, Songsong Zhu   +8 more
wiley   +1 more source

Modeling and simulation of neocortical micro- and mesocircuitry (Part I, anatomy). [PDF]

Elife
Reimann MW, Bolaños-Puchet S, Courcol JD, Egas Santander D, Arnaudon A, Coste B, Delalondre F, Delemontex T, Devresse A, Dictus H, Dietz A, Ecker A, Favreau C, Ficarelli G, Gevaert M, Herttuainen J, Isbister JB, Kanari L, Keller D, King J, Kumbhar P, Lapere S, Lazovskis J, Lu H, Ninin N, Pereira F, Planas J, Pokorny C, Riquelme JL, Romani A, Shi Y, Smith JP, Sood V, Srivastava M, Van Geit W, Vanherpe L, Wolf M, Levi R, Hess K, Schürmann F, Muller EB, Markram H, Ramaswamy S.   +42 more
europepmc   +1 more source

Crossing the Blood–Brain Barrier with Molecularly Imprinted Polymeric Nanocarriers: An Emerging Frontier in Brain Disease Therapy

Advanced Science, EarlyView.
Molecularly imprinted polymeric nanocarriers (nanoMIPs) offer robust, antibody‐mimetic platforms to overcome the blood‐brain barrier. The article surveys nanoMIP design and ligand‐directed surface engineering that harness receptor‐mediated transcytosis, and highlights therapeutic and diagnostic applications in neurodegeneration, brain tumors and ...
Ranjit De, Shuliang Shi, Kyong‐Tai Kim
wiley   +1 more source

Synaptic integration and competition in the substantia nigra pars reticulata-An experimental and in silico analysis. [PDF]

Proc Natl Acad Sci U S A
Thompson WS, Hjorth JJJ, Kozlov A, Thunberg W, Silberberg G, Hellgren Kotaleski J, Grillner S.   +6 more
europepmc   +1 more source

Hippocampal ripples down-regulate synapses

Science, 2018
H. Norimoto, Kenichi Makino, Mengxuan Gao, Yu Shikano, Kazuki Okamoto, Tomoe Ishikawa, T. Sasaki, H. Hioki, Shigeyoshi Fujisawa, Y. Ikegaya   +9 more
semanticscholar   +1 more source

Cell-autonomous reduction of CYFIP2 changes dendrite length, dendritic protrusion morphology, and inhibitory synapse density in the hippocampal CA1 pyramidal neurons of 17-month-old mice [PDF]

Yoonhee Kim, Ruiying Ma, Yinhua Zhang, Hyae Rim Kang, U Suk Kim, Kihoon Han   +5 more
openalex   +1 more source

Bidirectional Photoadaptive Organic Heterojunction Synaptic Transistors for Accurate Image Recognition in Machine Vision Systems

Advanced Science, EarlyView.
Bidirectional photoadaptive organic synaptic phototransistors are developed using complementary n–n and n‐p heterojunctions. These devices enable intelligent in‐sensor processing, markedly enhancing image contrast and edge features under adverse lighting, and achieve a recognition accuracy of 97.4% within ten training cycles for machine vision ...
Di Xue, Hongyu Liu, Yingying Zhang, Feng Ding, Jie Lu, Yao Yin, Zi Wang, Jianlong Xu, Lifeng Chi, Lizhen Huang   +9 more
wiley   +1 more source

Cryo-correlative light and electron tomography of dopaminergic axonal varicosities reveals non-synaptic modulation of cortico-striatal synapses. [PDF]

Nat Commun
Lapios P, Anger R, Paget-Blanc V, Marza E, Lučić V, Fronzes R, Herzog E, Perrais D.   +7 more
europepmc   +1 more source