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Annual Review of Immunology, 2001 The adaptive immune response is initiated by the interaction of T cell antigen receptors with major histocompatibility complex molecule-peptide complexes in the nanometer scale gap between a T cell and an antigen-presenting cell, referred to as an immunological synapse.
Andrey Shaw +2 more
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Molecular Immunology, 2002
The immunological synapse plays a central role in organising the immune system. Through their synaptic activity both T and B cells usually, but not always, acquire the information that critically determines the level and nature of the responses that they make. For T cells much of that information comes from epicrine and paracrine cell-cell interactions
R J, Creusot +2 more
openaire +2 more sources
The immunological synapse plays a central role in organising the immune system. Through their synaptic activity both T and B cells usually, but not always, acquire the information that critically determines the level and nature of the responses that they make. For T cells much of that information comes from epicrine and paracrine cell-cell interactions
R J, Creusot +2 more
openaire +2 more sources
The Neuroscientist, 2006
Synapses are packed with mitochondria, complex organelles with roles in energy metabolism, cell signaling, and calcium homeostasis. However, the precise mechanisms by which mitochondria influence neurotrans mission remain undefined.
Cindy V, Ly, Patrik, Verstreken
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Synapses are packed with mitochondria, complex organelles with roles in energy metabolism, cell signaling, and calcium homeostasis. However, the precise mechanisms by which mitochondria influence neurotrans mission remain undefined.
Cindy V, Ly, Patrik, Verstreken
openaire +2 more sources
European Journal of Neuroscience, 2014
AbstractIt has been several decades since synaptic dysfunction was first suggested to play a role in schizophrenia, but only in the last few years has convincing evidence been obtained as progress has been made in elucidating the genetic underpinnings of the disorder.
Andrew J, Pocklington +2 more
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AbstractIt has been several decades since synaptic dysfunction was first suggested to play a role in schizophrenia, but only in the last few years has convincing evidence been obtained as progress has been made in elucidating the genetic underpinnings of the disorder.
Andrew J, Pocklington +2 more
openaire +2 more sources
Progress in Neurobiology, 1997
Thalamocortical synapses inform the cerebral neocortex about the external and internal worlds. The thalamus produces myriad thalamocortical pathways that vary in morphological, physiological, pharmacological and functional properties. All these features are of great importance for understanding how information is acquired, integrated, processed, stored
M A, Castro-Alamancos, B W, Connors
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Thalamocortical synapses inform the cerebral neocortex about the external and internal worlds. The thalamus produces myriad thalamocortical pathways that vary in morphological, physiological, pharmacological and functional properties. All these features are of great importance for understanding how information is acquired, integrated, processed, stored
M A, Castro-Alamancos, B W, Connors
openaire +2 more sources