Results 271 to 280 of about 460,902 (390)

Synaptic Dysfunction in the Anterior Cingulate Cortex Underlies Pain‐Anxiety Comorbidity in a Mandibular Asymmetry Mouse Model

Advanced Science, EarlyView.
This study establishes a mandibular asymmetry (MA) mouse model that recapitulates chronic orofacial pain and anxiety comorbidity. Anterior cingulate cortex (ACC) hyperactivation and synaptic dysfunction are identified as central neural mechanisms underlying these pathologies, with chemogenetic inhibition of ACC CaMKII+ neurons effectively reversing ...
Zhaoyichun Zhang, Yanran Zhang, Jialin Si, Honghui Mao, Feng He, Jin Ning, Guaiguai Ma, Xiaohua Chen, Haoxiang Xiao, Yuanyuan Zhu, Haifeng Zhang, Yifan Lu, Qian Liu, Meng Nian, Shiquan Sun, Shibin Yu, Shengxi Wu, Ze Fan, Zuolin Jin, Jing Huang   +19 more
wiley   +1 more source

The synaptic architecture of layer 5 thick tufted excitatory neurons in mouse visual cortex. [PDF]

Nat Neurosci
Bodor AL, Schneider-Mizell CM, Zhang C, Elabbady L, Mallen A, Bergeson A, Brittain D, Buchanan J, Bumbarger DJ, Dalley R, Gamlin C, Joyce E, Kapner D, Kinn S, Mahalingam G, Seshamani S, Suckow S, Takeno M, Torres R, Yin W, Bae JA, Castro MA, Dorkenwald S, Halageri A, Jia Z, Jordan C, Kemnitz N, Lee K, Li K, Lu R, Macrina T, Mitchell E, Mondal SS, Mu S, Nehoran B, Popovych S, Silversmith W, Turner NL, Yu SC, Wong W, Wu J, Celii B, Campagnola L, Seeman SC, Jarsky T, Ren N, Arkhipov A, Reimer J, Seung HS, Reid RC, Collman F, da Costa NM.   +51 more
europepmc   +1 more source

Acetylcholine receptors at neuromuscular synapses: phylogenetic differences detected by snake alpha-neurotoxins.

, 1975
Steven J. Burden, H. Criss Hartzell, Doju Yoshikami   +2 more
openalex   +1 more source

Aptamer‐Mediated Artificial Synapses for Neuromorphic Modulation of Inflammatory Signaling via Organic Electrochemical Transistor

Advanced Science, EarlyView.
An aptamer‐mediated neuromorphic interface based on organic electrochemical transistors selectively transduces interleukin‐6 (IL‐6) signals into neuromorphic electrical outputs. This protein‐driven neuromorphic plasticity, responsive in physiological and in vivo environmental electrolyte, bridges biochemical signaling with artificial neural encoding ...
Yuqing Ding, You Kuai, Rongpei Li, Xinzhao Xu, Bo Wang, Zhihui Wang, Yanfang Liu, Yuchao Dong, Shunjie Chen, Meng Guo, Yunqi Liu, Yan Zhao   +11 more
wiley   +1 more source

Synaptic accumulation of GluN2B-containing NMDA receptors mediates the effects of BDNF-TrkB signalling on synaptic plasticity and in hyperexcitability during status epilepticus. [PDF]

J Biomed Sci
De Luca P, Mele M, Tanqueiro S, Napoli F, Butkevičiūtė U, Souto AC, Costa RO, Schwarz A, Drexel M, Sebastião AM, Diógenes MJ, Duarte CB.   +11 more
europepmc   +1 more source

"Hybrid" synapses formed by foreign innervation of parasympathetic neurons: a model for selectivity during competitive reinnervation.

, 1979
William R. Proctor, S. Frenk, Barry Taylor, Stephen D. Roper   +3 more
openalex   +1 more source

Semiconducting Nanomaterials for Intrinsically Stretchable Field‐Effect Transistors

Advanced Science, EarlyView.
This review discusses intrinsically stretchable field‐effect transistors, highlighting recent developments in stretchable semiconducting nanomaterials and fabrication methods. Key material strategies and innovative deposition techniques enabling enhanced mechanical elasticity alongside reliable electronic properties are covered.
Seongmin Heo, Gwon Byeon, Soonhyo Kim, Taoyu Zou, Yong‐Young Noh   +4 more
wiley   +1 more source

Resource-dependent heterosynaptic spike-timing-dependent plasticity in recurrent networks with and without synaptic degeneration. [PDF]

Front Comput Neurosci
Humble J.
europepmc   +1 more source

Treating Hearing Loss: From Cochlear Implantation to Gene Therapy

Advanced Science, EarlyView.
Cochlear implantation is the primary treatment for deafness, restoring functional hearing in over a million people. Recently, gene therapy has enabled biological hearing restoration in a small number of patients with OTOF‐related mutations. This perspective evaluates both approaches, concluding that cochlear implants will remain the standard for most ...
Fan‐Gang Zeng, Jieyu Qi, Chen‐Chi Wu, Yilai Shu, Renjie Chai   +4 more
wiley   +1 more source

Interleaving asynchronous and synchronous activity in balanced cortical networks with short term synaptic depression. [PDF]

Nat Commun
Dunworth JB, Xu Y, Graupner M, Ermentrout B, Reyes AD, Doiron B.   +5 more
europepmc   +1 more source