Results 201 to 210 of about 23,521 (333)

Defective Chromosome Synapsis and Recombination in Azoospermic Men [PDF]

, 2005
Renée H. Martin, Fei Sun, Edmund Ko, Alfred Rademaker, Calvin Greene, P.J. Turek   +5 more
openalex   +1 more source

LncRNA THUMPD3‐AS1 Regulates Behavioral and Synaptic Structural Abnormalities in Schizophrenia via miR‐485‐5p and ARHGAP8

Advanced Science, EarlyView.
Schizophrenia (SCZ) is linked to synaptic structural deficits driven by dysregulated noncoding RNAs. Using the novel ceRNAxis pipeline, THUMPD3‐AS1/miR‐485‐5p/ARHGAP8 is identified as a key regulator of actin cytoskeletal remodeling through noncanonical RhoB/C‐ROCK2 signaling. Modulating this axis ameliorates SCZ‐like phenotypes in mice and aligns with
Xiaojuan Gong, Lingxi Chen, Xin Guo, Anna Jiang, Yayi He, Chunxia Yan, Liang Ma, Jiayang Gao, Jinyu Zhang, Bao Zhang   +9 more
wiley   +1 more source

A nuclear TRiC/CCT chaperonin assembles meiotic HORMAD proteins into chromosome axes competent for crossing over. [PDF]

Nat Commun
Zetka M, Pezeshki A, Dawson R, Huis In 't Veld PJ, Jones SJM, Silva N.   +5 more
europepmc   +1 more source

Synapsis and catalysis by activated Tn3 resolvase mutants [PDF]

, 2008
Femi J. Olorunniji, Jiuya He, Sandra V. C. T. Wenwieser, Martin R. Boocock, W. Marshall Stark   +4 more
openalex   +1 more source

Single‐Field Evolution Rule Governs the Dynamics of Representational Drift in Mouse Hippocampal Dorsal CA1 Region

Advanced Science, EarlyView.
Long‐term hippocampal place‐code dynamics are investigated using calcium imaging across weeks of maze navigation. Analyses reveal a novelty‐irrelevant Single‐Field Evolution Rule (SFER), where active fields promote persistence and inactive fields decline.
Cong Chen, Shuyang Yao, Sihui Cheng, Jiayi Tian, Ang Li, Yusen Yan, Xiang Zhang, Yuanjing Liu, Yumeng Wang, Qichen Cao, Chenglin Miao   +10 more
wiley   +1 more source

Sexually dimorphic control of crossover distribution by the conserved ATPase PCH-2 in <i>C. elegans</i>. [PDF]

MicroPubl Biol
Herrera A, Pacheco B, Patel B, Holland K, Bhalla N.   +4 more
europepmc   +1 more source

Synapsis and recombination mechanisms

, 2020
In organisms, recombination is an important event providing a variation to adapt their environment. The mechanism of recombination is a complicated event coming out between homologous chromosomes. The chromosome pairing in recombination is a phenomenon for genetic information flow.
openaire   +1 more source

Morphological and Hyperphosphorylation Transitions of Nanoscale Tau Aggregates in Alzheimer's Disease

Advanced Science, EarlyView.
Super‐resolution microscopy identifies nano‐sized tau aggregates (nano‐aggregates) and reveals distinct transitions in their morphology and phosphorylation profiles across control, Primary Age‐Related Tauopathy, and Alzheimer's disease brains. Morphology and hyperphosphorylation signatures distinguish physiological from pathological forms, with nano ...
Adriana N. Santiago‐Ruiz, Siewert Hugelier, Gabriela L. Correa, Charles R. Bond, Edward B. Lee, Melike Lakadamyali   +5 more
wiley   +1 more source

Tendency towards clonality: deviations of meiosis in parthenogenetic Caucasian rock lizards†. [PDF]

Biol Reprod
Spangenberg V, Arakelyan M, Simanovsky SA, Dombrovskaya Y, Khachatrian ER, Kolomiets O.   +5 more
europepmc   +1 more source

TRIM56 Aggravates Cerebral Ischemia‐Reperfusion Injury via Inhibiting KLF4‐Activated Ferroptosis Signaling

Advanced Science, EarlyView.
This study reveals that the E3 ubiquitin ligase TRIM56 exacerbates neuronal ferroptosis and brain damage by mediating K48‐linked ubiquitination and degradation of KLF4, leading to suppression of the xCT/GSH/GPX4 axis. Targeting TRIM56 alleviates cerebral ischemia‐reperfusion injury in vivo and in vitro, highlighting its therapeutic potential.
Qiangping Wang, Shuang Li, Man Li, Wenke Zhou, Jianqing Zhang, Zhenfu Wu, Zhaoqi Mao, Juan Wan, Xinhao Tang, Baoping Zheng, Qiang Liu, Zhendong Li, Xiaobing Jiang, Qingping Wu, Youfan Ye, Haijun Wang   +15 more
wiley   +1 more source