Results 251 to 260 of about 23,521 (333)

Crossovers are regulated by a conserved and disordered synaptonemal complex domain. [PDF]

Nucleic Acids Res
Neves ARR, Čavka I, Rausch T, Köhler S.   +3 more
europepmc   +1 more source

Initial Distance‐Dependent Mean Force Drives Synaptic Vesicle Motion Toward Fusion Sites in Stimulated Hippocampal Neurons

Advanced Science, EarlyView.
Synaptic vesicle (SV) motion and exocytosis dynamics in the presynaptic terminals of live neurons are intimately linked to synaptic transmission during neuronal activity. In this work, it is revealed that, during electrical stimulation, SVs located farther from their fusion sites exhibit greater straightness and experience larger mean forces directed ...
Gyunam Park, Ji‐Hyun Kim, Hunki Lee, Chungwon Park, Sidong Chen, Luke Bates, Jaeyoung Sung, Hyokeun Park   +7 more
wiley   +1 more source

The full-length BEND2 protein is dispensable for spermatogenesis but required for setting the ovarian reserve in mice. [PDF]

Elife
Huang Y, Bucevic N, Coves C, Felipe-Medina N, Marcet-Ortega M, Nikou N, Madrid-Sandín C, López-Panadés M, Buza C, Ferrer Miralles N, Iborra A, Pujol A, Pendás AM, Roig I.   +13 more
europepmc   +1 more source

Hungry for Knowledge: Octopamine Signaling Regulates Hunger‐Enhanced Olfactory Learning

Advanced Science, EarlyView.
Researchers demonstrate that hunger state facilitates both aversive and appetitive olfactory learning. Two distinct octopamine signaling pathways are involved in aversive or appetitive memory formation in the hunger state. And, hunger state also facilitates the formation of both types of memories via an evolutionarily conserved norepinephrine (the ...
Huijuan Zhao, Guiyuan Shi, Ruixue Qin, Yinghao Sun, Wenbo Guo, Ruixia Shi, Minxian Peng, Jingxuan Yang, Jianjian Zhao, Qiuhan Liu, Jun Xiao, Ke Zhang, Qiang Liu, Wenxing Yang, He Liu   +14 more
wiley   +1 more source

A nucleoskeleton network preserves genomic integrity by promoting NHEJ and restraining chromosome translocations. [PDF]

Nucleic Acids Res
Liu J, Bai X, Chen X, Li B, Zhao H, Wu J, Ye Y, Yu J, Yan Z, Guo R, Xu D, Li W.   +11 more
europepmc   +1 more source

Harnessing Time‐Dependent Magnetic Texture Dynamics via Spin‐Orbit Torque for Physics‐Enhanced Neuromorphic Computing

Advanced Science, EarlyView.
A neuromorphic computing platform using spin‐orbit torque‐controlled magnetic textures is reported. The device implements bio‐inspired synaptic functions and achieves high performance in both pattern recognition (>93%) and combinatorial optimization (>95%), enabling unified processing of cognitive and optimization tasks.
Yifan Zhang, Yu Li, Huai Lin, Xinying Wang, Long Liu, Guoliang Xing, Di Wang, Zhihao Zhao, Zhipeng Guo, Junbo Yang, Jiebin Niu, Yan Sun, Tom Wu, Guozhong Xing   +13 more
wiley   +1 more source

The conserved SEN1 DNA/RNA helicase has multiple functions during yeast meiosis. [PDF]

PLoS Genet
Gaglione R, Pierrakeas L, Wan L, Caradonna J, MacQueen AJ, Luk E, Hollingsworth NM.   +6 more
europepmc   +1 more source

USP11‐PGAM5 Axis Promotes Neurotoxic Astrocyte Reactivity by Aggravating the mtDNA‐cGAS‐STING Pathway After Intracerebral Hemorrhage

Advanced Science, EarlyView.
This study reveals that the deubiquitinase USP11 stabilizes PGAM5, triggering neurotoxic astrocyte transformation after intracerebral hemorrhage. PGAM5 promotes mPTP opening and Drp1 dephosphorylation, synergistically amplifying mtDNA leakage into the cytosol and leading to cGAS–STING hyperactivation.
Jiaqing He, Zijuan Qin, Yaning Cai, Haixiao Liu, Tinghao Wang, Qing Hu, Yanni Xu, Pan Yang, Xun Wu, Yan Qu, Wei Guo   +10 more
wiley   +1 more source

Editorial: Molecular architecture and dynamics of meiotic chromosomes

Frontiers in Cell and Developmental Biology
Ricardo Benavente, Ricardo Benavente, Mónica Pradillo, Pedro A. San-Segundo   +3 more
doaj   +1 more source

Distinct functions of PAXX and MRI during chromosomal end joining. [PDF]

iScience
Cisneros-Aguirre M, Lopezcolorado FW, Ping X, Chen R, Stark JM.   +4 more
europepmc   +1 more source