Results 51 to 60 of about 23,404 (333)

A conserved filamentous assembly underlies the structure of the meiotic chromosome axis. [PDF]

, 2019
The meiotic chromosome axis plays key roles in meiotic chromosome organization and recombination, yet the underlying protein components of this structure are highly diverged.
Caballero, Iracema, Corbett, Kevin D, Hagemann, Götz, Herzog, Franz, Lehmer, Madison K, MacQueen, Amy J, Rosenberg, Scott C, Ur, Sarah N, Usón, Isabel, West, Alan Mv, Ye, Qiaozhen   +10 more
core   +4 more sources

Long‐term hippocampal alterations and cognitive impairment in a murine model of surgical sepsis

FEBS Open Bio, EarlyView.
Using a mouse model of surgical sepsis, we tested long‐term memory and analyzed the transcriptome of single cells isolated from the hippocampus. Survivor mice showed worse memory, loss of certain brain cell subpopulations, and abnormal immune cell activity—suggesting that post‐sepsis brain alterations may be linked to cognitive deficits.
Dong Seong Cho, Rebecca Schmitt, Aneesha Dasgupta, Alexandra Ducharme, Jason Doles   +4 more
wiley   +1 more source

Developmental, Neuroanatomical and Cellular Expression of Genes Causing Dystonia

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Dystonia is one of the most common movement disorders, with variants in multiple genes identified as causative. However, an understanding of which developmental stages, brain regions, and cell types are most relevant is crucial for developing relevant disease models and therapeutics.
Darren Cameron, Nicholas E. Clifton, Daniel Cabezas de la Fuente, Peter Holmans, Nicholas J. Bray, Kathryn J. Peall   +5 more
wiley   +1 more source

Telomeres cluster de novo before the initiation of synapsis: a three-dimensional spatial analysis of telomere positions before and during meiotic prophase. [PDF]

, 1997
We have analyzed the progressive changes in the spatial distribution of telomeres during meiosis using three-dimensional, high resolution fluorescence microscopy.
Agard, DA, Bass, HW, Cande, WZ, Marshall, WF, Sedat, JW   +4 more
core  

Principles of meiotic chromosome assembly revealed in S. cerevisiae [PDF]

, 2019
During meiotic prophase, chromosomes organise into a series of chromatin loops emanating from a proteinaceous axis, but the mechanisms of assembly remain unclear.
A Goloborodko, A Hayashi, A Lengronne, A Storlazzi, A Tedeschi, AL Sanborn, AV Smith, B Bonev, D Thacker, D Zickler, E Alipour, E Crane, E Trelles-Sticken, EF Glynn, EP Nora, EP Nora, F Klein, G Fudenberg, G Fudenberg, G Fudenberg, G Wutz, GA Busslinger, H Jin, H Muller, H Tjong, H Wong, J Dekker, J Dekker, J Gassler, J Li, JA Carballo, JF Marko, JHI Haarhuis, JM Belton, JR Dixon, K Challa, K Nasmyth, KG Alavattam, L Lazar-Stefanita, L Patel, L Xu, M Ito, M Merkenschlager, M Sym, M Sym, MN Conrad, N Naumova, N Servant, NJ Petela, NM Hollingsworth, O Crawley, P Eastman, P Eastman, P Kerpedjiev, PB Møens, Q Jin, S Heinz, S Maleki, S Panizza, SA Schalbetter, SSP Rao, SSP Rao, T Mizuguchi, T Sakuno, TS Hsieh, VV Subramanian, W Schwarzer, Y Blat, Y Kakui, Y Wang   +69 more
core   +2 more sources

Paramagnetic Rim Lesions Are Associated With Trans‐Synaptic Degeneration of the Visual Pathway in Multiple Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives Retrograde trans‐synaptic degeneration (rTSD) from posterior visual pathway lesions in multiple sclerosis (MS) is characterized by hemi‐macular ganglion cell‐inner plexiform layer (GCIPL) thinning and contralateral visual field loss.
Abdul Jaber Tayem, Angel Liu, Sargis Manukyan, Mustafa Subhi, Elaina Luskin, Bryan Quah, Sreekanth Madhusoodhanan Nair, Arzu C. Has Silemek, Gabriela Zabala, Yujie Cui, Laura Locke, Paula Barreras, Marwa Kaisey, Vinicius Calsavara, Daniel S. Reich, Nancy L. Sicotte, Pascal Sati, Omar Al‐Louzi   +17 more
wiley   +1 more source

The conserved ATPase PCH-2 controls the number and distribution of crossovers by antagonizing their formation in Caenorhabditis elegans

eLife
Meiotic crossover recombination is essential for both accurate chromosome segregation and the generation of new haplotypes for natural selection to act upon. This requirement is known as crossover assurance and is one example of crossover control.
Bhumil Patel, Maryke Grobler, Alberto Herrera, Elias Logari, Valery Ortiz, Needhi Bhalla   +5 more
doaj   +1 more source

Phosphorylation of chromosome core components may serve as axis marks for the status of chromosomal events during mammalian meiosis.

PLoS Genetics, 2012
Meiotic recombination and chromosome synapsis between homologous chromosomes are essential for proper chromosome segregation at the first meiotic division. While recombination and synapsis, as well as checkpoints that monitor these two events, take place
Tomoyuki Fukuda, Florencia Pratto, John C Schimenti, James M A Turner, R Daniel Camerini-Otero, Christer Höög   +5 more
doaj   +1 more source

All‐in‐One Analog AI Hardware: On‐Chip Training and Inference with Conductive‐Metal‐Oxide/HfOx ReRAM Devices

Advanced Functional Materials, EarlyView.
An all‐in‐one analog AI accelerator is presented, enabling on‐chip training, weight retention, and long‐term inference acceleration. It leverages a BEOL‐integrated CMO/HfOx ReRAM array with low‐voltage operation (<1.5 V), multi‐bit capability over 32 states, low programming noise (10 nS), and near‐ideal weight transfer.
Donato Francesco Falcone, Victoria Clerico, Wooseok Choi, Tommaso Stecconi, Folkert Horst, Laura Bégon‐Lours, Matteo Galetta, Antonio La Porta, Nikhil Garg, Fabien Alibart, Bert Jan Offrein, Valeria Bragaglia   +11 more
wiley   +1 more source

A quality control mechanism coordinates meiotic prophase events to promote crossover assurance.

PLoS Genetics, 2014
Meiotic chromosome segregation relies on homologous chromosomes being linked by at least one crossover, the obligate crossover. Homolog pairing, synapsis and meiosis specific DNA repair mechanisms are required for crossovers but how they are coordinated ...
Alison J Deshong, Alice L Ye, Piero Lamelza, Needhi Bhalla   +3 more
doaj   +1 more source