Results 61 to 70 of about 26,216 (365)
Contribution of Tau Pathology to Mitochondrial Impairment in Neurodegeneration
Frontiers in Neuroscience, 2018 Tau is an essential protein that physiologically promotes the assembly and stabilization of microtubules, and participates in neuronal development, axonal transport, and neuronal polarity.
María J. Pérez +5 more
doaj +1 more source
A Meiotic Checkpoint Alters Repair Partner Bias to Permit Inter-sister Repair of Persistent DSBs [PDF]
, 2019 Accurate meiotic chromosome segregation critically depends on the formation of inter-homolog crossovers initiated by double-strand breaks (DSBs). Inaccuracies in this process can drive aneuploidy and developmental defects, but how meiotic cells are ...
Aguilera López, Andrés +7 more
core +1 more source
Inhibitor analysis of synapsis by resolvase
Journal of Biological Chemistry, 1989 Previously, we isolated several inhibitors that block the site-specific recombination reaction mediated by the Tn3-encoded resolvase protein. One class of inhibitors blocks resolvase binding to the recombination (res) sitc, and a second class inhibits synapse formation between resolvase and two directly repeated res sites.
Peter M. Flanagan +3 more
openaire +3 more sources
A Role for SUMO in Meiotic Chromosome Synapsis [PDF]
Current Biology, 2006 During meiotic prophase, homologous chromosomes engage in a complex series of interactions that ensure their proper segregation at meiosis I. A central player in these interactions is the synaptonemal complex (SC), a proteinaceous structure elaborated along the lengths of paired homologs. In mutants that fail to make SC, crossing over is decreased, and
Gillian W. Hooker +2 more
openaire +3 more sources
UBR2 of the N-end rule pathway is required for chromosome stability via histone ubiquitylation in spermatocytes and somatic cells [PDF]
, 2012 The N-end rule pathway is a proteolytic system in which its recognition components (N-recognins) recognize destabilizing N-terminal residues of short-lived proteins as an essential element of specific degrons, called N-degrons.
An, JY +12 more
core +1 more source
Frontiers in Plant Science, 2017 The production of balanced fertile haploid gametes requires the faithful separation of paired (synapsed) chromosomes toward the end of meiotic prophase I (desynapsis).
Isabelle Colas +9 more
doaj +1 more source
bioRxiv, 2018 Accurate chromosome segregation during meiosis relies on the prior establishment of at least one crossover recombination event between homologous chromosomes, which is often associated with the meiosis-specific MutSγ complex.
K. Voelkel-Meiman +8 more
semanticscholar +1 more source
PLoS Genetics, 2012 Chromosomes that fail to synapse during meiosis become enriched for chromatin marks associated with heterochromatin assembly. This response, called meiotic silencing of unsynapsed or unpaired chromatin (MSUC), is conserved from fungi to mammals.
Piero Lamelza, Needhi Bhalla
doaj +1 more source
Proceedings of the National Academy of Sciences of the United States of America, 2014 Tao Zheng +5 more
openalex +2 more sources
Chromosome Synapsis Alleviates Mek1-Dependent Suppression of Meiotic DNA Repair
PLoS Biology, 2016 Faithful meiotic chromosome segregation and fertility require meiotic recombination between homologous chromosomes rather than the equally available sister chromatid, a bias that in Saccharomyces cerevisiae depends on the meiotic kinase, Mek1.
Vijayalakshmi V. Subramanian +7 more
semanticscholar +1 more source