Results 221 to 230 of about 107,361 (347)
Continuous Vesicle Cycling in the Synaptic Terminal of Retinal Bipolar Cells [PDF]
Leon Lagnado, Ana Gomis, Christy Job
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Neurodegenerative and Neurodevelopmental Roles for Bulk Lipid Transporters VPS13A and BLTP2
Abstract Background Bridge‐like lipid transfer proteins (BLTPs) mediate bulk lipid transport at membrane contact sites. Mutations in BLTPs are linked to both early‐onset neurodevelopmental and later‐onset neurodegenerative diseases, including movement disorders.
Sarah D. Neuman+4 more
wiley +1 more source
Synapsin condensation controls synaptic vesicle sequestering and dynamics. [PDF]
Hoffmann C+14 more
europepmc +1 more source
Synaptic Vesicle Recycling in Cultured Cerebellar Granule Cells: Role of Vesicular Acidification and Refilling [PDF]
Michael A. Cousin, David G. Nicholls
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Abstract Background Deep brain stimulation (DBS) elicits oscillatory local field potentials in patients with Parkinson's disease (PD) and other movement disorders. Greater knowledge about the fast dynamics of these neural responses could shed light on circuit pathophysiology and inform novel approaches to neuromodulation therapies.
Sarah Brinkerhoff+7 more
wiley +1 more source
Endocytosis of VAMP is facilitated by a synaptic vesicle targeting signal. [PDF]
Eric Grote, R B Kelly
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ABSTRACT Neuroimaging with positron emission tomography (PET) has been instrumental in elucidating neurobiological mechanisms behind therapeutical trials in Parkinson's disease (PD). A variety of medical and neurosurgical interventions have been evaluated using many radioligands that reveal molecular basis for target engagement and brain responses in ...
Vijay Dhawan+4 more
wiley +1 more source
Redistribution of synaptic vesicles and their proteins in temperature-sensitive shibire(ts1) mutant Drosophila. [PDF]
Jana van de Goor+2 more
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Abstract Traditionally, clinical trials of putative disease‐modifying therapies in Parkinson's disease have enrolled untreated patients at the earliest clinical stages of their disease. Due to a number of challenges inherent with this approach, there has been a recent move to a different study design, enrolling patients who are already taking “stable ...
M. Maral Mouradian+2 more
wiley +1 more source