Results 271 to 280 of about 531,557 (374)

Positron Emission Tomography Imaging in Clinical Trials for Parkinson's Disease: Applications of Metabolic Brain Network Approach

open access: yesMovement Disorders, EarlyView.
ABSTRACT Neuroimaging with positron emission tomography (PET) has been instrumental in elucidating neurobiological mechanisms behind therapeutical trials in Parkinson's disease (PD). A variety of medical and neurosurgical interventions have been evaluated using many radioligands that reveal molecular basis for target engagement and brain responses in ...
Vijay Dhawan   +4 more
wiley   +1 more source

Synaptotagmin 7 docks synaptic vesicles to support facilitation and Doc2α-triggered asynchronous release. [PDF]

open access: yesElife
Wu Z   +7 more
europepmc   +1 more source

BACE1 controls synaptic function through modulating release of synaptic vesicles. [PDF]

open access: yesMol Psychiatry, 2021
Das B   +6 more
europepmc   +1 more source

Disease‐Modifying Trials in Treated Parkinson's Disease: “Stable Treated” Does Not Equate with Biological Stability

open access: yesMovement Disorders, EarlyView.
Abstract Traditionally, clinical trials of putative disease‐modifying therapies in Parkinson's disease have enrolled untreated patients at the earliest clinical stages of their disease. Due to a number of challenges inherent with this approach, there has been a recent move to a different study design, enrolling patients who are already taking “stable ...
M. Maral Mouradian   +2 more
wiley   +1 more source

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