Results 301 to 310 of about 549,591 (370)

Different priming states of synaptic vesicles underlie distinct release probabilities at hippocampal excitatory synapses.

Neuron, 2022
Aldahabi M, Balint F, Holderith N, Lorincz A, Reva M, Nusser Z.   +5 more
europepmc   +1 more source

Hearing requires otoferlin-dependent efficient replenishment of synaptic vesicles in hair cells

Nature Neuroscience, 2010
T. Pangršič, Livia Lasarow, K. Reuter, H. Takago, M. Schwander, D. Riedel, Thomas Frank, L. Tarantino, J. Bailey, N. Strenzke, N. Brose, U. Müller, E. Reisinger, T. Moser   +13 more
semanticscholar   +1 more source

The Second Hit Hypothesis in Animal and Human Dystonia: The Role of Peripheral Nerve Trauma and Spinal Cord Injury

Movement Disorders, EarlyView.
The “second‐hit” hypothesis proposes that both a genetic predisposition and an environmental insult—such as peripheral nerve trauma or spinal cord injury—are required for dystonia development. This review explores how neuroinflammation and maladaptive plasticity, triggered by nerve and spinal cord injury, contribute to dystonia pathogenesis.
Lisa Harder‐Rauschenberger, Chi Wang Ip   +1 more
wiley   +1 more source

Endosomal sorting of readily releasable synaptic vesicles

Proceedings of the National Academy of Sciences of the United States of America, 2010
P. Hoopmann, A. Punge, Sina V. Barysch, V. Westphal, J. Bueckers, F. Opazo, Ioanna Bethani, M. Lauterbach, S. Hell, S. Rizzoli   +9 more
semanticscholar   +1 more source

LRRK2 as a Potential Disease‐Modifying Target in Sporadic Parkinson's Disease

Movement Disorders, EarlyView.
Abstract A growing understanding of the role that leucine‐rich repeat kinase 2 (LRRK2) plays in Parkinson's disease (PD) supports continued focus on this enzyme as a therapeutic target for PD. Accumulating evidence suggests that there are phenotypic, neuropathologic, and biological similarities between sporadic PD (sPD) and familial forms in which ...
Anthony E. Lang, Robert A. Hauser, Lorraine V. Kalia, Bonnie Hersh, Zdenek Berger, Roy Llorens Arenas, Coro Paisan‐Ruiz, Kyle Fraser, Danna Jennings, Jillian H. Kluss, Sarah Huntwork‐Rodriguez, Anastasia G. Henry, J. Timothy Greenamyre   +12 more
wiley   +1 more source

The same synaptic vesicles drive active and spontaneous release

Nature Neuroscience, 2010
Benjamin G. Wilhelm, T. W. Groemer, S. Rizzoli   +2 more
semanticscholar   +1 more source

Nuclear Alpha‐Synuclein: Mechanisms and Implications for Synucleinopathies

Movement Disorders, EarlyView.
Abstract Alpha‐synuclein (aSyn), historically studied for its synaptic functions and central role in Lewy body pathology, is emerging as a protein with significant nuclear activities relevant to Parkinson's disease (PD) and related synucleinopathies. Recent advances reveal that aSyn dynamically localizes to neuronal nuclei in both health and disease ...
Tiago Fleming Outeiro, David J. Koss
wiley   +1 more source

Erratum: Imbrosci et al., "Automated Detection and Localization of Synaptic Vesicles in Electron Microscopy Images". [PDF]

eNeuro, 2022
europepmc   +1 more source

Cholesterol reduction impairs exocytosis of synaptic vesicles

Journal of Cell Science, 2010
Anna Linetti, A. Fratangeli, E. Taverna, Pamela Valnegri, M. Francolini, V. Cappello, M. Matteoli, M. Passafaro, P. Rosa   +8 more
semanticscholar   +1 more source

Focused Ultrasound for the Treatment of Circuit and Molecular Pathology in Parkinson's Disease

Movement Disorders, EarlyView.
Abstract Focused ultrasound is rapidly emerging as a novel technology for the development of symptomatic therapies and supporting disease‐modifying treatments for Parkinson's disease (PD). At the forefront of this development is thermoablation using high‐intensity focused ultrasound, an incisionless treatment that has been extensively tested in ...
Rikke Hahn Kofoed, Victor Schwartz Hvingelby, Jose A. Pineda‐Pardo, Javier Blesa, Steffen Paschen, Anurag Tandon, Juho Joutsa, Andreas Nørgaard Glud   +7 more
wiley   +1 more source