Results 311 to 320 of about 531,557 (374)
Elimination of zinc from synaptic vesicles in the intact mouse brain by disruption of the ZnT 3 gene
, 1999 Toby B. Cole +4 more
openalex +1 more source
PROTEOMICS, EarlyView.ABSTRACT One of the traditional treatments in Alzheimer's disease (AD) is administration of memantine, the NMDA receptor antagonist. However, the molecular mechanism of the complex memantine action and the impact on the hippocampal proteome in humans is unknown.
Ivo Fabrik +12 more
wiley +1 more source
The same synaptic vesicles drive active and spontaneous release
Nature Neuroscience, 2010 Benjamin G. Wilhelm +2 more
semanticscholar +1 more source
Plasma Proteomic Profiling of a Group of Anxious Dogs by LC‐MS/MS: A Case–Control Study
PROTEOMICS – Clinical Applications, EarlyView.ABSTRACT Purpose Anxiety is the most common underlying cause of behavioral problems in dogs, which remain a top reason for relinquishment and euthanasia. Despite its high prevalence, anxiety is often underdiagnosed, partly due to a limited understanding of biological processes and absence of diagnostic biomarkers.
Claudia Gaither +4 more
wiley +1 more source
CPT: Pharmacometrics &Systems Pharmacology, EarlyView.ABSTRACT The spatial progression hypothesis of misfolded tau and alpha‐synuclein proteins in Alzheimer's and Parkinson's Disease proposes the release of proteins from a presynaptic membrane followed by diffusion over the synaptic cleft and uptake by the postsynaptic membrane in the afferent neuron.
Jamie Goff +4 more
wiley +1 more source
Update on Gene Therapy in the Treatment of Hereditary Hearing Loss
Sensory Neuroscience, EarlyView.Gene therapy is a promising therapeutic approach for genetic disorders, including three major gene therapy strategies: gene replacement, gene suppression, and gene editing. After transmitting genes to the inner ear through appropriate pathways, repair the cochlea in order to achieve the goal of treating hereditary hearing loss.
Weiwei He +7 more
wiley +1 more source
Secretome Profiling in Axon Regeneration: Emerging Techniques and Therapeutic Translation
Sensory Neuroscience, EarlyView.ABSTRACT The secretome refers to the in vivo ensemble of molecular entities that are found in interstitial spaces. It is then the mere secreted products of the cells, as all biomolecules in the interstitial cellular spaces also undergo modifications. The fractionated secretome may hold potential as a cell‐free therapy option due to its role in tissue ...
Maria D. Cabrera +3 more
wiley +1 more source
Conductive Materials and Electrical Stimulation for Auditory Restoration
Sensory Neuroscience, EarlyView.Applications of electroconductive biomaterials and electrical stimulation in cochlear tissue engineering.(1) Enable auditory neural repair through conductive materials and electrical stimulation, enhancing neuron survival and synaptic plasticity.(2) Integrate optogenetic‐electrical systems and cochlear organoid platforms for frequency‐specific ...
Menghui Liao +8 more
wiley +1 more source
Astrocyte Lipid Droplet Dynamics Orchestrate Neurological Disorders and Therapeutic Horizons
Small Science, EarlyView.This review examines astrocyte lipid droplet (LD) metabolism in neurological disorders, including Alzheimer's disease, stroke, epilepsy, and glioma. It analyzes regulatory mechanisms governing LD formation, transport, and degradation in astrocytes, highlighting their potential as biomarkers and therapeutic targets through integrative multiomics ...
Jiani Zhong +4 more
wiley +1 more source
Self‐Driving Microscopes: AI Meets Super‐Resolution Microscopy
Small Methods, EarlyView.This review examines the use of machine learning to automate super‐resolution optical microscopy, enabling the microscope to autonomously make decisions on what, when, and how to image. By eliminating the need for human intervention, this approach has the potential to enhance the versatility and accessibility of super‐resolution microscopy.
Edward N. Ward +3 more
wiley +1 more source