Results 321 to 330 of about 549,591 (370)

Nanomedicine Meets Immunotherapy: Transforming Chimeric Antigen Receptor T Cell Treatment for Solid Tumors

Small Science, EarlyView.
This review highlights recent advances in nanomedicine that enhance chimeric antigen receptor (CAR) T cell therapy against solid tumors. It discusses key barriers to CAR T cell efficacy and outlines nanotechnology‐based strategies to improve tumor targeting, remodel the immunosuppressive microenvironment, and integrate nanomaterials into CAR T cell ...
Stephen O’Rourke, Nuo Xu, Hongjun Wang, Hexin Chen   +3 more
wiley   +1 more source

Organic Transistor‐Based Neuromorphic Electronics and Their Recent Applications

Small Methods, EarlyView.
This review highlights recent progress in organic neuromorphic electronics, showing how organic semiconductors enable synaptic and neuronal functions with low power, mechanical flexibility, and biocompatibility. By bridging materials, devices, and systems, organic platforms are accelerating brain‐inspired computing toward applications in artificial ...
Ziru Wang, Feng Yan
wiley   +1 more source

Dopamine: The Essential Bridge Mediating Obstructive Sleep Apnea and Hippocampus‐Dependent Learning and Memory Impairments

World Journal of Otorhinolaryngology - Head and Neck Surgery, EarlyView.
ABSTRACT Obstructive sleep apnea is a clinical syndrome that triggers a series of pathophysiologic changes, including disturbed sleep architecture, chronic intermittent hypoxia and hypercapnia, and ultimately severe cognitive dysfunction. The hippocampus plays a key role in various cognitive processes such as learning and memory.
Rui Fan, Tao Li, Yan Yan
wiley   +1 more source

The shibirets4 mutation causes temperature sensitive paralytic and lethal phenotypes in the Queensland fruit fly, Bactrocera tryoni

Insect Science, EarlyView.
Abstract Bactrocera tryoni, the Queensland fruit fly, is among the most damaging insect pests to the Australian horticultural industry as larvae infest ripening fruits or vegetables prior to harvest. Genetic biocontrol using Sterile Insect Technique (SIT) programs have been used to successfully suppress populations, via mass release of factory‐reared ...
Anzu Okada, Mamoru Okamoto, Thu N.M. Nguyen, Elisabeth Fung, Han Nguyen, Peter Crisp, Amanda Choo, Simon W. Baxter   +7 more
wiley   +1 more source

Neoclassical development of genetic sexing strains for insect pest and disease vector control

Insect Science, EarlyView.
The sterile insect technique has been effectively used for decades, and an important component is the availability of sex separation systems, in particular genetic sexing strains. Classical approaches, such as irradiation‐induced chromosomal translocations, have yielded stable strains for species like the Mediterranean fruit fly.
Giovanni Petrucci, Maria‐Eleni Gregoriou, Philippos Aris Papathanos, Marc F. Schetelig, Zhijian Tu, Kostas Bourtzis   +5 more
wiley   +1 more source

Extraocular Photoreception in Optic Lobes, Suckers, and Skin of Octopus vulgaris

Integrative Zoology, EarlyView.
Evidence of extra‐ocular photoreception in Octopus vulgaris (a) Diagram of the O. vulgaris different tissues considered: SPB, sucker proximal big; SPL, sucker proximal large; SM, sucker medium; SD, sucker distal; SK, skin; OL, optic lobes; RT, retina; (b‐d) Gene expression analysis of Ov‐GRK1 (red), Ov‐retinochrome (green), Ov‐rhodopsin (blue) mRNA ...
Valeria Maselli, Al‐Sayed Al‐Soudy, Mariangela Norcia, Stefania Galdiero, Sara Palladino, Emanuela Cirillo, Gianluca Polese, Anna Di Cosmo   +7 more
wiley   +1 more source

Prenatal Environmental Hypoxia Enhances Adult Hypoxia Tolerance in Brandt's Voles (Lasiopodomys brandtii): Behavioral and Transcriptomic Insights

Integrative Zoology, EarlyView.
Prenatal hypoxia enhances adult hypoxia tolerance in Brandt's voles, preserving cognitive and memory functions. Transcriptomic analysis reveals adaptive changes in energy metabolism, oxygen transport, and neuroprotective mechanisms, highlighting developmental plasticity.
Mengyang Li, Congcong Qiao, Xiujuan Li, Maolin Huang, Zhenlong Wang, Luye Shi   +5 more
wiley   +1 more source

Decoding Dual Regulatory Layers: Integrating Differential Expression and Alternative Splicing Dynamics in the Evolution of Laryngeal Echolocation Across Chiropteran Lineages

Integrative Zoology, EarlyView.
We integrated short‐read and long‐read RNA‐seq data from cochlear tissues of echolocating and non‐echolocating bats to disentangle transcriptional and post‐transcriptional regulation. Echolocating bats showed neural‐function enrichment among differentially expressed genes, while alternatively spliced genes were linked to epigenetic regulation. Overlaps
Jianyu Wu, Daoyuan Hu, Min Chen, Xiuguang Mao   +3 more
wiley   +1 more source

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The synaptic vesicle cycle.

Annual Review of Neuroscience, 2004
▪ Abstract  Neurotransmitter release is mediated by exocytosis of synaptic vesicles at the presynaptic active zone of nerve terminals. To support rapid and repeated rounds of release, synaptic vesicles undergo a trafficking cycle. The focal point of the vesicle cycle is Ca2+-triggered exocytosis that is followed by different routes of endocytosis and ...
T. Sūdhof
semanticscholar   +3 more sources

Synaptic Vesicle Biogenesis

Annual Review of Cell and Developmental Biology, 1999
▪ Abstract  Synaptic vesicles, which have been a paradigm for the fusion of a vesicle with its target membrane, also serve as a model for understanding the formation of a vesicle from its donor membrane. Synaptic vesicles, which are formed and recycled at the periphery of the neuron, contain a highly restricted set of neuronal proteins.
M J, Hannah, A A, Schmidt, W B, Huttner
openaire   +2 more sources