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Synaptic vesicle pools

Nature Reviews Neuroscience, 2005
Communication between cells reaches its highest degree of specialization at chemical synapses. Some synapses talk in a 'whisper'; others 'shout'. The 'louder' the synapse, the more synaptic vesicles are needed to maintain effective transmission, ranging from a few hundred (whisperers) to nearly a million (shouters).
Silvio O, Rizzoli, William J, Betz
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Synaptic vesicle cycle

Toxicon, 2008
Neurotransmitter release from presynaptic nerve endings is mediated by Ca2+-dependent exocytosis of synaptic vesicles. During the past 15 years, major progress has been made in unravelling the molecular mechanisms underlying exocytosis and the recycling of synaptic vesicles.
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Formation of synaptic vesicles

Current Opinion in Cell Biology, 1994
Synaptic vesicles (SVs) are specialized secretory organelles used for the fast and focal signaling between nerve cells. They are small and homogeneous in size (50 nm), and contain non-peptide neurotransmitters such as glutamate, gamma-aminobutyric acid (GABA) and acetylcholine. The exocytosis of SVs occurs at low rates in resting nerve terminals and is
O, Mundigl, P, De Camilli
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Isolation of Synaptic Vesicles

Current Protocols in Cell Biology, 2004
AbstractSynaptic vesicles are the most abundant secretory organelle in eukaryotic neural cells. Synaptic vesicles are physically distinct from other membrane‐bound organelles because they are small, spherical, and highly uniform in size with a diameter of about 40 nm.
Branch, Craige   +2 more
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Biogenesis of synaptic vesicles

Journal of Cell Science, 1993
ABSTRACT The basic endosomal recycling pathway can be modified to generate transcytotic vesicles, storage vesicles and synaptic vesicles. Sorting into synaptic vesicles requires specialized sorting information not present in the transcytotic and storage vesicle proteins.
R B, Kelly   +5 more
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THE SYNAPTIC VESICLE CYCLE

Annual Review of Physiology, 1998
▪ Abstract  The ins and outs of the synaptic vesicle cycle are being examined in increasing detail with diverse investigative tools in a variety of cell types, particularly those with large granules. The cycle begins with the opening of a fusion pore that connects the vesicle lumen to the extracellular fluid.
W J, Betz, J K, Angleson
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Synaptic Vesicles and Exocytosis

Annual Review of Neuroscience, 1994
Neurons transmit information by releasing neurotransmitters from presynaptic nerve endings, In the resting stage , transmitters are stored in small organelles of uniform size and shape , the synaptic vesicles . When an action potential arrives in the nerve terminal , the membrane depolarizes and voltage-gated Ca2+ channels open .
R, Jahn, T C, Südhof
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Synaptic vesicle life cycle and synaptic turnover

Journal of Physiology-Paris, 1993
Cholinergic synaptic vesicles contain a mixture of soluble low molecular mass constituents. Besides acetylcholine these include Ca2+, ATP, GTP, small amounts of ADP and AMP, and also the diadenosine polyphosphates Ap4A and Ap5A. In synaptic vesicles isolated from the electric ray these diadenosine polyphosphates occur in mmol concentrations and might ...
H, Zimmermann   +3 more
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The Synaptic Vesicle

1984
Synaptic vesicles are the characteristic organelles of the presynaptic nerve terminals of chemical synapses (i.e., those utilizing the release of a specific chemical transmitter substance to bring about synaptic transmission). They are normally 45–50 nm in diameter and must be among the most homogeneous and uniform lipoprotein membrane organelles known.
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SYNAPTIC VESICLE HETEROGENEITY

Journal of Neurochemistry, 1984
R M, Marchbanks   +2 more
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