Results 331 to 340 of about 531,557 (374)

Accumulation of GSK‐3β in Interneurons Impairs Adult Hippocampal Neurogenesis by Inhibiting GABAergic Transmission

Aging Cell, EarlyView.
Overexpression of GSK‐3β in DG GABAergic neurons impairs neurogenesis by reducing GABA release, which can be reversed by enhancing GABAergic transmission. ABSTRACT The activation of glycogen synthase kinase 3β (GSK‐3β) and the deterioration of spatial memory represent prominent pathological and clinical manifestations of Alzheimer's disease (AD ...
Fei Liu, Jiu‐Jing Cui, Xiao‐Lin Li, Zeng‐Min Zhang, Shao‐Hua Liang, Yi Sun, Jing‐Min Li, Hong‐Lin Qu, Jing Ye, Qi‐Peng Guo, Quan Zheng, Yong‐Feng Liu   +11 more
wiley   +1 more source

The role of auditory sensory input during functional pre- and postsynaptic maturation of the calyx of Held synapse. [PDF]

, 2007
Erazo Fischer, E.
core   +1 more source

Regenerative Response 35 Days After Esophageal Replacement in a Porcine Model; Technical Difficulties and Attempts to Achieve Optimal Tissue Remodeling

Artificial Organs, EarlyView.
ABSTRACT Background In previous articles, a porcine model for bridging circumferential defects in the intrathoracic esophagus was developed. The aims of this present study were to evaluate the continued healing response after 35 days, avoid stent migration of the esophageal stent, and to investigate whether it would be beneficial to add new ...
A. Sandin, L. Jönsson, E. Jennische, M. Dellenmark Blom, L.‐G. Friberg, V. Gatzinsky, O. Holmqvist, K. Abrahamsson   +7 more
wiley   +1 more source

Psilocybin as a novel treatment for chronic pain

British Journal of Pharmacology, EarlyView.
Abstract Psychedelic drugs are under active consideration for clinical use and have generated significant interest for their potential as anti‐nociceptive treatments for chronic pain, and for addressing conditions like depression, frequently co‐morbid with pain.
Tate Askey, Reena Lasrado, Maria Maiarú, Gary J. Stephens   +3 more
wiley   +1 more source

Contributions of synaptic energetic dysfunction by microtubule dynamics and microtubule‐based mitochondrial transport disorder to morphine tolerance

British Journal of Pharmacology, EarlyView.
Abstract Background and Purpose Morphine is among the most powerful analgesic, but its long‐term use can cause tolerance. Synaptic ATP supply is critical for maintaining synaptic transmission. Microtubule‐based mitochondrial transport ensures synaptic energy supply.
Zheng Li, Jie Liu, Jie Ju, Xiaoling Peng, Wei Zhao, Jihao Ren, Xiaoqian Jia, Jihong Wang, Ye Tu, Feng Gao   +9 more
wiley   +1 more source

Experimental Parkinsonism induced by tetanus toxin injected into basal ganglia

British Journal of Pharmacology, EarlyView.
Abstract Background and Purpose Local inhibitory circuits and long‐range inhibitory projections within the interconnected basal ganglia nuclei are critical for control of voluntary movement and pathophysiology of different extrapyramidal movement disorders.
Patrik Meglić, Petra Šoštarić, Davor Virag, Ana Knezović, Nikola Habek, Ornella Rossetto, Ivica Matak   +6 more
wiley   +1 more source

The thoracic perivascular adipose tissue spontaneously induces vasoconstriction through activation of α1‐adrenoceptors

British Journal of Pharmacology, EarlyView.
Background and Purpose Although perivascular adipose tissue (PVAT) contains substances with contractile properties, its actions on the vascular tone are associated with the release of anticontractile substances. We hypothesize that procontractile PVAT products also exert direct effects on vascular tone. Experimental Approach Thoracic aortas from Wistar
Leonardo Gomes‐Pereira, José Eduardo da Silva‐Santos   +1 more
wiley   +1 more source

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The synaptic vesicle cycle.

Annual Review of Neuroscience, 2004
Neurotransmitter release is mediated by exocytosis of synaptic vesicles at the presynaptic active zone of nerve terminals. To support rapid and repeated rounds of release, synaptic vesicles undergo a trafficking cycle.
T. Sūdhof
semanticscholar   +4 more sources

Synaptic Vesicle Biogenesis [PDF]

Annual Review of Cell and Developmental Biology, 1999
▪ Abstract  Synaptic vesicles, which have been a paradigm for the fusion of a vesicle with its target membrane, also serve as a model for understanding the formation of a vesicle from its donor membrane. Synaptic vesicles, which are formed and recycled at the periphery of the neuron, contain a highly restricted set of neuronal proteins.
Matthew J. Hannah, Wieland B. Huttner, Anne A. Schmidt   +2 more
openaire   +2 more sources

Synaptic vesicles

Biochemical Pharmacology, 1970
Abstract Isolated synaptosomes from guinea pig brain homogenates incorporated choline- 14 C when incubated either in a medium with an external energy source or in one containing only Tris buffer. The incorporation was divisible into three fractions: total, TCA-insoluble, and chloroform-soluble.
Brian A. Hemsworth, H B Bosmann
openaire   +3 more sources