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Formation of synaptic vesicles
Current Opinion in Cell Biology, 1994Synaptic vesicles (SVs) are specialized secretory organelles used for the fast and focal signaling between nerve cells. They are small and homogeneous in size (50 nm), and contain non-peptide neurotransmitters such as glutamate, gamma-aminobutyric acid (GABA) and acetylcholine. The exocytosis of SVs occurs at low rates in resting nerve terminals and is
O Mundigl, Pietro De Camilli
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Synaptic Vesicles and Exocytosis [PDF]
Annual Review of Neuroscience, 1994 Neurons transmit information by releasing neurotransmitters from presynaptic nerve endings, In the resting stage , transmitters are stored in small organelles of uniform size and shape , the synaptic vesicles . When an action potential arrives in the nerve terminal , the membrane depolarizes and voltage-gated Ca2+ channels open .
Reinhard Jahn, Thomas C. Südhof
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Isolation of Synaptic Vesicles
Current Protocols in Cell Biology, 2004AbstractSynaptic vesicles are the most abundant secretory organelle in eukaryotic neural cells. Synaptic vesicles are physically distinct from other membrane‐bound organelles because they are small, spherical, and highly uniform in size with a diameter of about 40 nm.
Gloria Salazar +2 more
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Biogenesis of synaptic vesicles
Journal of Cell Science, 1993ABSTRACT The basic endosomal recycling pathway can be modified to generate transcytotic vesicles, storage vesicles and synaptic vesicles. Sorting into synaptic vesicles requires specialized sorting information not present in the transcytotic and storage vesicle proteins.
Regis B. Kelly +5 more
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Synaptic Vesicles in the Cochlea
Acta Oto-Laryngologica, 1974The cochlea is innervated by afferent, efferent and sympathetic neurons. The afferent synapses and the efferent and sympathetic nerve terminals contain transmitter substances within their synaptic vesicles. These transmitters are likely to be chemically different in each of the three cochlear nerve populations.
Ove Densert, A Flock, E Borg
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Nature Reviews Neuroscience, 2005
Communication between cells reaches its highest degree of specialization at chemical synapses. Some synapses talk in a 'whisper'; others 'shout'. The 'louder' the synapse, the more synaptic vesicles are needed to maintain effective transmission, ranging from a few hundred (whisperers) to nearly a million (shouters).
William J. Betz, Silvio O. Rizzoli
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Communication between cells reaches its highest degree of specialization at chemical synapses. Some synapses talk in a 'whisper'; others 'shout'. The 'louder' the synapse, the more synaptic vesicles are needed to maintain effective transmission, ranging from a few hundred (whisperers) to nearly a million (shouters).
William J. Betz, Silvio O. Rizzoli
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Syntaxin: a synaptic protein implicated in docking of synaptic vesicles at presynaptic active zones.
Science, 1992Synaptic vesicles store neurotransmitters that are released during calcium-regulated exocytosis. The specificity of neurotransmitter release requires the localization of both synaptic vesicles and calcium channels to the presynaptic active zone.
M. Bennett, N. Calakos, R. Scheller
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‘Synaptic Vesicles’ in the Neurohypophysis
Nature, 1960ELECTRON microscope studies of the neurohypophysis have shown that the terminal branches of the hypothalamo-hypophysial tract fibres contain, in addition to mitochondria, vesicles or granules of two kinds distinguished by their size1,2. The larger inclusions each have a diameter of the order of 100–300 mµ, (1000–3000 A.), and are thought to represent ...
R. L. Holmes, Francis Knowles
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Annual Review of Physiology, 1998
▪ Abstract The ins and outs of the synaptic vesicle cycle are being examined in increasing detail with diverse investigative tools in a variety of cell types, particularly those with large granules. The cycle begins with the opening of a fusion pore that connects the vesicle lumen to the extracellular fluid.
Joseph K. Angleson, William J. Betz
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▪ Abstract The ins and outs of the synaptic vesicle cycle are being examined in increasing detail with diverse investigative tools in a variety of cell types, particularly those with large granules. The cycle begins with the opening of a fusion pore that connects the vesicle lumen to the extracellular fluid.
Joseph K. Angleson, William J. Betz
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Uptake of glutamate into synaptic vesicles by an inorganic phosphate transporter.
Science, 2000Previous work has identified two families of proteins that transport classical neurotransmitters into synaptic vesicles, but the protein responsible for vesicular transport of the principal excitatory transmitter glutamate has remained unknown.
Elizabeth E. Bellocchio +3 more
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