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Synaptic Vesicle Phosphoproteins and Regulation of Synaptic Function
Science, 1993Complex brain functions, such as learning and memory, are believed to involve changes in the efficiency of communication between nerve cells. Therefore, the elucidation of the molecular mechanisms that regulate synaptic transmission, the process of intercellular communication, is an essential step toward understanding nervous system function.
GREENGARD P. +3 more
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1984
Synaptic vesicles are the characteristic organelles of the presynaptic nerve terminals of chemical synapses (i.e., those utilizing the release of a specific chemical transmitter substance to bring about synaptic transmission). They are normally 45–50 nm in diameter and must be among the most homogeneous and uniform lipoprotein membrane organelles known.
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Synaptic vesicles are the characteristic organelles of the presynaptic nerve terminals of chemical synapses (i.e., those utilizing the release of a specific chemical transmitter substance to bring about synaptic transmission). They are normally 45–50 nm in diameter and must be among the most homogeneous and uniform lipoprotein membrane organelles known.
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Mechanisms of Synaptic Vesicle Exocytosis
Annual Review of Cell and Developmental Biology, 2000▪ Abstract Chemical synaptic transmission serves as the main form of cell to cell communication in the nervous system. Neurotransmitter release occurs through the process of regulated exocytosis, in which a synaptic vesicle releases its contents in response to an increase in calcium.
Richard H. Scheller, Richard C. Lin
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ELECTROPHYSIOLOGY OF SYNAPTIC VESICLE CYCLING
Annual Review of Physiology, 1999▪ Abstract Patch-clamp capacitance measurements can monitor in real time the kinetics of exocytosis and endocytosis in living cells. We review the application of this technique to the giant presynaptic terminals of goldfish bipolar cells. These terminals secrete glutamate via the fusion of small, clear-core vesicles at specialized, active zones of ...
Henrique von Gersdorff, Gary Matthews
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Exocytosis and Synaptic Vesicle Function
Comprehensive Physiology, 2014AbstractSynaptic vesicles release their vesicular contents to the extracellular space by Ca2+‐triggered exocytosis. The Ca2+‐triggered exocytotic process is regulated by synaptotagmin (Syt), a vesicular Ca2+‐binding C2 domain protein. Synaptotagmin 1 (Syt1), the most studied major isoform among 16 Syt isoforms, mediates Ca2+‐triggered synaptic vesicle ...
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Science Signaling, 2012
Tracking of individual synaptic vesicles reveals that kiss-and-run fusion is concentrated near the center of the synapse.
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Tracking of individual synaptic vesicles reveals that kiss-and-run fusion is concentrated near the center of the synapse.
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Toxicon, 2008
Neurotransmitter release from presynaptic nerve endings is mediated by Ca2+-dependent exocytosis of synaptic vesicles. During the past 15 years, major progress has been made in unravelling the molecular mechanisms underlying exocytosis and the recycling of synaptic vesicles.
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Neurotransmitter release from presynaptic nerve endings is mediated by Ca2+-dependent exocytosis of synaptic vesicles. During the past 15 years, major progress has been made in unravelling the molecular mechanisms underlying exocytosis and the recycling of synaptic vesicles.
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1988
Most nerve terminals contain various types of vesicles which differ with regard to their appearance in the electron-microscope and presumably also their molecular properties. Profiles of cholinergic nerve terminals from e.g. motor neurons or parasympathetic fibres contain in addition to the numerous electron-lucent vesicles with a diameter of about 45 ...
Walter Volknandt +2 more
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Most nerve terminals contain various types of vesicles which differ with regard to their appearance in the electron-microscope and presumably also their molecular properties. Profiles of cholinergic nerve terminals from e.g. motor neurons or parasympathetic fibres contain in addition to the numerous electron-lucent vesicles with a diameter of about 45 ...
Walter Volknandt +2 more
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2008
Synapses locally recycle vesicles to ensure the maintenance of neuronal communication critical for normal brain function. While several modes of vesicle regeneration are thought to exist, clathrin-mediated endocytosis (CME) is the best studied mechanism of synaptic vesicle recycling.
Patrik Verstreken, Liesbet Smitz
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Synapses locally recycle vesicles to ensure the maintenance of neuronal communication critical for normal brain function. While several modes of vesicle regeneration are thought to exist, clathrin-mediated endocytosis (CME) is the best studied mechanism of synaptic vesicle recycling.
Patrik Verstreken, Liesbet Smitz
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The synaptic vesicle and its targets
Neuroscience, 1995Synaptic vesicles play the central role in synaptic transmission. They are regarded as key organelles involved in synaptic functions such as uptake, storage and stimulus-dependent release of neurotransmitter. In the last few years our knowledge concerning the molecular components involved in the functioning of synaptic vesicles has grown impressively ...
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