Results 101 to 110 of about 21,364,816 (201)

Synaptotagmin VII as a Plasma Membrane Ca2+ Sensor in Exocytosis [PDF]

, 2001
Synaptotagmins I and II are Ca2+ binding proteins of synaptic vesicles essential for fast Ca2+-triggered neurotransmitter release. However, central synapses and neuroendocrine cells lacking these synaptotagmins still exhibit Ca2+-evoked exocytosis.
Fernández-Chacón, Rafael, Shuzo Sugita, Xinran Liu, Liu, Xinran, Sugita, Shuzo, Weiping Han, Lao, Ye, Han, Weiping, Stefan Butz, Südhof, Thomas C., Ye Lao, Thomas C. Südhof, Butz, Stefan, Rafael Fernández-Chacón   +13 more
core   +1 more source

Immunogold labeling of synaptic vesicle proteins in developing hippocampal neurons

Molecular Brain, 2020
Synaptic vesicles (SV) contain high concentrations of specific proteins. How these proteins are transported from soma to synapses, and how they become concentrated at SV clusters at presynaptic terminals were examined by immunogold electron microscopy in
Jung-Hwa Tao-Cheng
doaj   +1 more source

The juxtamembrane linker of synaptotagmin 1 regulates Ca2+ binding via liquid-liquid phase separation

Nature Communications
Synaptotagmin (syt) 1, a Ca2+ sensor for synaptic vesicle exocytosis, functions in vivo as a multimer. Syt1 senses Ca2+ via tandem C2-domains that are connected to a single transmembrane domain via a juxtamembrane linker.
Nikunj Mehta, Sayantan Mondal, Emma T. Watson, Qiang Cui, Edwin R. Chapman   +4 more
doaj   +1 more source

Dataset associated with "The role of the C2A domain of synaptotagmin 1 in asynchronous neurotransmitter release"

, 2020
This dataset includes all raw data for experiments included in the manuscript. It also includes raw, unedited microscopy and blot images.Following nerve stimulation, there are two distinct phases of Ca2+-dependent neurotransmitter release: a fast ...
Bowers, Matthew, Metz, Marissa, Shields, Mallory, Perinet, Lara, Reist, Noreen, Kramer, Hannah, Fulcer, McKenzie   +6 more
core   +1 more source

New insights into molecular pathways associated with flatfish ovarian development and atresia revealed by transcriptional analysis

BMC Genomics, 2009
Background The Senegalese sole (Solea senegalensis) is a marine flatfish of increasing commercial interest. However, the reproduction of this species in captivity is not yet controlled mainly because of the poor knowledge on its reproductive physiology ...
Agulleiro María J, Lozano Juanjo, Chauvigné François, Tingaud-Sequeira Angèle, Asensio Esther, Cerdà Joan   +5 more
doaj   +1 more source

Peripheral Nerve Injury is Accompanied by Chronic Transcriptome-Wide Changes in the Mouse Prefrontal Cortex

Molecular Pain, 2013
Background Peripheral nerve injury can have long-term consequences including pain-related manifestations, such as hypersensitivity to cutaneous stimuli, as well as affective and cognitive disturbances, suggesting the involvement of supraspinal mechanisms.
Sebastian Alvarado, Maral Tajerian, Magali Millecamps, Mathew Suderman, Laura S Stone, Moshe Szyf   +5 more
doaj   +1 more source

Interaction of Stoned and Synaptotagmin in Synaptic Vesicle Endocytosis

, 2001
TheDrosophiladicistronicstonedlocus encodes two distinctive presynaptic proteins, Stoned A (STNA) and Stoned B (STNB); STNA is a novel protein without homology to known synaptic proteins, and STNB contains a domain with homology to the endocytotic ...
Kendal Broadie, Tim Fergestad
core   +1 more source

Synaptotagmin-1 attenuates myocardial programmed necrosis and ischemia/reperfusion injury through the mitochondrial pathway

Cell Death and Disease
Programmed necrosis/necroptosis greatly contributes to the pathogenesis of cardiac disorders including myocardial infarction, ischemia/reperfusion (I/R) injury and heart failure.
Teng Sun, Jialei Li, Shuang Wang, Yu Han, Xiangyu Tao, Min Yuan, Zhijie Jing, Ting Liu, Yuehong Qi, Siqi Liu, Yanlin Feng, Jiasong Chang, Lan Zhou, Lijuan Gao, Jianyun Shi, Ruihong Ning, Jimin Cao   +16 more
doaj   +1 more source

High fat diet affects the hippocampal expression of miRNAs targeting brain plasticity-related genes

Scientific Reports
Metabolic disorders such as insulin resistance and type 2 diabetes are associated with brain dysfunction and cognitive deficits, although the underpinning molecular mechanisms remain elusive.
Matteo Spinelli, Francesco Spallotta, Chiara Cencioni, Francesca Natale, Agnese Re, Alice Dellaria, Antonella Farsetti, Salvatore Fusco, Claudio Grassi   +8 more
doaj   +1 more source

Cellular localization of synaptotagmin I, II, and III mRNAs in the central nervous system and pituitary and adrenal glands of the rat

, 1995
Three isoforms of synaptotagmin, a synaptic vesicle protein involved in neurotransmitter release, have been characterized in the rat, although functional differences between these isoforms have not been reported.
M Mizuta, N Inagaki, JA Boudier, B Marqueze, S Seino, M Seagar   +5 more
core   +1 more source