Results 81 to 90 of about 21,364,816 (201)

Impaired Motor Function in a Zebrafish Stathmin‐2 Knockout Model

Developmental Neurobiology, Volume 86, Issue 4, October 2026.
ABSTRACT Stathmin‐2 (STMN2) is a microtubule‐associated protein that plays a role in the stability of microtubules in axons of the nervous system of animals. In this study, we generated a novel zebrafish STMN2 knockout (KO) model. STMN2 is represented by two genes in the zebrafish genome: stmn2a and stmn2b.
Tyler J. N. Gurberg, Ziyaan A. Harji, Christian J. Rampal, Joséphine Sacy‐Richer, Amy Wang, Esteban C. Rodríguez, Gary A. B. Armstrong   +6 more
wiley   +1 more source

Morphologically Docked Synaptic Vesicles Are Reduced insynaptotagminMutants ofDrosophila [PDF]

The Journal of Neuroscience, 1998
Nerve terminal specializations include mechanisms for maintaining a subpopulation of vesicles in a docked, fusion-ready state. We have investigated the relationship between synaptotagmin and the number of morphologically docked vesicles by an electron microscopic analysis ofDrosophila synaptotagmin(syt) mutants.
N E, Reist, J, Buchanan, J, Li, A, DiAntonio, E M, Buxton, T L, Schwarz   +5 more
openaire   +2 more sources

Exploring the Impact of Urolithins A and B on Muscle Health: A Transcriptomic Analysis in Human Myotubes

Journal of Cachexia, Sarcopenia and Muscle, Volume 17, Issue 5, October 2026.
ABSTRACT Background Urolithin A (UA) and urolithin B (UB) are gut microbiota‐derived metabolites of ellagitannins reported to influence mitochondrial function, inflammation and muscle metabolism. Their comparative transcriptomic effects in human skeletal muscle cells remain undefined.
Yves Henrotin, Antoine Florin, Christelle Sanchez, Prescilia Centonze, Tiago Pinto Coelho, Sophie Bekisz, Jean‐Emile Dubuc, Olivier Galand, Cécile Lambert   +8 more
wiley   +1 more source

Perspectives for pharmaceutical screening at XFEL sources using the example of Lassa virus endonuclease

Acta Crystallographica Section D, Volume 82, Issue 10, Page 1181-1194, October 2026.
To facilitate structure‐based drug development, XFEL sources are of paramount interest. Here, we analyse the feasibility and data quality of serial femtosecond X‐ray crystallography compound screening at Linac Coherent Light Source and compare it with PETRA III synchrotron experiments.
Sven Falke, Patrick Y. A. Reinke, Daniel Rosenberg, Pontus Fischer, Jan Meyer, Marina Galchenkova, Alexandra Tolstikova, Valerio Mariani, Johanna M. Senst, Philipp Lewe, Susanne Witt, Armin Wagner, Henry N. Chapman, Mark Hunter, Sebastian Günther, Alke Meents   +15 more
wiley   +1 more source

Phosphorylation of synaptotagmin I by casein kinase II.

Journal of Biological Chemistry, 1993
Synaptotagmin I is an abundant synaptic vesicle protein that binds Ca2+ in a phospholipid-dependent manner and is thought to function in synaptic vesicle exocytosis. We have now studied the phosphorylation of synaptotagmin I. Synaptotagmin I is one of the major substrates in brain for casein kinase II, which phosphorylates synaptotagmin at a single ...
B, Davletov, J M, Sontag, Y, Hata, A G, Petrenko, E M, Fykse, R, Jahn, T C, Südhof   +6 more
openaire   +2 more sources

Membrane Penetration by Synaptotagmin Is Required for Coupling Calcium Binding to Vesicle FusionIn Vivo [PDF]

, 2011
The vesicle protein synaptotagmin I is the Ca2+sensor that triggers fast, synchronous release of neurotransmitter. Specifically, Ca2+binding by the C2B domain of synaptotagmin is required at intact synapses, yet the mechanism whereby Ca2+binding results ...
Laurie M. Biela, Edwin R. Chapman, Michael D. Getzy (7935758), David E. Featherstone, Kaiyun Chen (364164), Noreen E. Reist (7935767), Brie E. Paddock, Kaiyun Chen, Laurie M. Biela (7935755), Michael D. Getzy, Noreen E. Reist, Edwin R. Chapman (359702), Amelia Striegel (7935761), Janet E. Richmond (7935764), Brie E. Paddock (7935752), David E. Featherstone (364169), Janet E. Richmond, Zhao Wang, Amelia Striegel, Zhao Wang (145195)   +19 more
core   +1 more source

Postnatal developmental changes in the laryngeal chemosensory cell clusters of rats

Journal of Anatomy, Volume 249, Issue 4, Page 769-786, October 2026.
Chemosensory cell clusters appeared in the rat larynx 2 days after birth and were already connected to afferent nerve fibers. Their number increased until 3 weeks of age, then stabilized while continuing to grow through the addition of new cells. Because their number reached a plateau around the time of weaning, their development may be linked to ...
Sayed Sharif Abdali, Kanna Miyazaki, Takuya Yokoyama, Nobuaki Nakamuta, Tomoyuki Saino, Yoshio Yamamoto   +5 more
wiley   +1 more source

Turnip mosaic virus utilizes the lipid droplet biogenesis machinery to facilitate its propagation in plants

New Phytologist, Volume 252, Issue 2, Page 797-816, October 2026.
Potyvirus turnip mosaic virus induces neutral lipid accumulation and lipid droplet biogenesis in infected leaves for its own benefit. See also the Commentary on this article by May & Nagy, 252: 525–527. Summary Lipid droplets (LDs), which are dedicated to storing neutral lipids (NLs), are dynamic organelles involved in numerous other functions ...
Léna Jambou, Nathalie Arvy, Marguerite Batsale, Luc Sofer, Sara Shakir, Marielle Cochet, Vincent Simon, Charlotte Quinteau, Thomas Scotti, Nathan M. Doner, Satinder K. Gidda, Robert T. Mullen, Sabine D'Andréa, Jean‐Luc Gallois, Denis Coulon, Claire Bréhélin, Sylvie German‐Retana   +16 more
wiley   +1 more source

Palmitoylation sites and processing of synaptotagmin I, the putative calcium sensor for neurosecretion [PDF]

, 2003
Synaptotagmin I, the calcium sensor for neurotransmission, is palmitoylated. We have identified the palmitoylation sites as five cysteine residues located between the transmembrane and cytoplasmic regions.
Veit, Michael, Heindel, Ulrich, Schmidt, Michael F.G, Michael Veit, Ulrich Heindel, Michael F.G Schmidt   +5 more
core   +1 more source

ASXL1 in proinflammatory macrophages attenuates inflammatory activation and macrophage‐mediated renal tubular epithelial cell damage in acute kidney injury

Physiological Reports, Volume 14, Issue 19, October 2026.
ASXL1 in inflammatory macrophages attenuates renal tubular cell damage through coordinated histone modification of H3K27me3 and H3K4me3 in acute kidney injury. Abstract Macrophages are major contributors to inflammatory responses in acute kidney injury (AKI) and rapidly alter their gene expression through epigenetic regulation.
Yoshiyasu Ogura, Takehito Sugasawa, Masaomi Nangaku, Imari Mimura   +3 more
wiley   +1 more source