Results 61 to 70 of about 21,364,816 (201)

Analysis of the Differentiation of Kenyon Cell Subtypes Using Three Mushroom Body-Preferential Genes during Metamorphosis in the Honeybee (Apis mellifera L.). [PDF]

PLoS ONE, 2016
The adult honeybee (Apis mellifera L.) mushroom bodies (MBs, a higher center in the insect brain) comprise four subtypes of intrinsic neurons: the class-I large-, middle-, and small-type Kenyon cells (lKCs, mKCs, and sKCs, respectively), and class-II KCs.
Shota Suenami, Rajib Kumar Paul, Hideaki Takeuchi, Genta Okude, Tomoko Fujiyuki, Kenichi Shirai, Takeo Kubo   +6 more
doaj   +1 more source

Transformer‐Based PET/CT Fusion Enables Preoperative Prediction and Prognostic Stratification of Spread Through Air Spaces in Lung Adenocarcinoma

Advanced Science, EarlyView.
An eight‐stream 2.5D Transformer integrates complementary PET metabolic and CT morphologic information to estimate spread‐through‐air‐spaces risk before surgery in lung adenocarcinoma. The model generalizes across independent centers, while its continuous risk score independently stratifies progression‐free survival, supporting further prospective ...
Xin‐Yu Zhu, Meng Meng, Zhen‐Zhen Wang, Deng‐Lu Lu, Ya‐Min Wei, Xu‐Chang Mi, Xing‐Yu Mu, Wei Fu   +7 more
wiley   +1 more source

Intracellular calcium dependence of large dense-core vesicle exocytosis in the absence of synaptotagmin I.

, 2001
Synaptotagmin I is a synaptic vesicle-associated protein essential for synchronous neurotransmission. We investigated its impact on the intracellular Ca2+-dependence of large dense-core vesicle (LDCV) exocytosis by combining Ca2+-uncaging and membrane ...
Suedhof, T., Neher, E. ; https://orcid.org/, Lund, P E, Suedhof, T. C., Moser, T, Chow, Robert H., M. Geppert, T. Moser, Südhof, T C, Moser, Tobias, Neher, E, Geppert, M, E. Neher, Lund, P. E., Chow, R. H., Voets, T., T. Voets, Lund, P., Geppert, M., P.-E. Lund, Moser, T., T. C. Sudhof, Neher, E., Suedhof, Thomas C., Neher, Erwin, R. H. Chow, Chow, R H, Voets, T, Chow, R.   +28 more
core   +1 more source

The Plasmodesmal Localization Signal of TMV MP Is Recognized by Plant Synaptotagmin SYTA

mBio, 2018
Plant viruses cross the barrier of the plant cell wall by moving through intercellular channels, termed plasmodesmata, to invade their hosts. They accomplish this by encoding movement proteins (MPs), which act to alter plasmodesmal gating. How MPs target
Cheng Yuan, Sondra G. Lazarowitz, Vitaly Citovsky   +2 more
doaj   +1 more source

Biallelic PIGB Variants Cause Motor Neuropathy with Conduction Blocks and Peripheral Nerve Hyperexcitability

Annals of Neurology, EarlyView.
Objective Glycosylphosphatidylinositol (GPI)‐anchored proteins play critical roles in nervous system function. Pathogenic variants in genes involved in GPI‐anchor biosynthesis cause early‐onset multisystem disorders known as inherited GPI deficiencies. We describe a novel neuromuscular phenotype associated with PIGB deficiency.
Gorka Fernández‐Eulate, Romain Duval, Marina Konyukh, Alessandro Bertini, Ayse Candayan, Albena Jordanova, Theresa Brunet, Wolfgang Müller‐Felber, Helena F. Pernice, Katrin Hahn, Nadja Ehmke, Juliane Beuschlein, Bertrand Isidor, Benjamin Cogné, Yann Péréon, Annabelle Chaussenot, John Rendu, Aysylu Murtazina, Dmitrii Subbotin, Artem Borovikov, Andrey Marakhonov, Chiara Pisciotta, Paola Saveri, Daniele Cazzato, Lucie Lemeray, Bérengère Koehl, Jean‐Madeleine de Sainte‐Agathe, Stefano Facchini, Ilaria Quartesan, Andrea Cortese, Yesim Parman, Arman Cakar, Davide Pareyson, Slim Azouzi, Tanya Stojkovic   +34 more
wiley   +1 more source

Localization of synaptotagmin-binding domains on syntaxin

, 1996
Synaptotagmin, an abundant calcium- and phospholipid-binding protein of synaptic vesicles, has been proposed to regulate neurotransmitter release at the nerve terminal.
Y Kee, RH Scheller
core   +1 more source

Gβγ and the C terminus of SNAP-25 are necessary for long-term depression of transmitter release. [PDF]

PLoS ONE, 2011
Short-term presynaptic inhibition mediated by G protein-coupled receptors involves a direct interaction between G proteins and the vesicle release machinery. Recent studies implicate the C terminus of the vesicle-associated protein SNAP-25 as a molecular
Xiao-lei Zhang, Chirag Upreti, Patric K Stanton   +2 more
doaj   +1 more source

Efficacy of fenfluramine in a pediatric epilepsy patient with a pathogenic SV2A variant: A case report

Epileptic Disorders, EarlyView.
Abstract Pathogenic SV2A gene variants have been reported as causes of epilepsy and are often associated with drug resistance and susceptibility to fever‐related seizures. No highly effective treatments have been established for this condition. We report a female patient with a family history of epilepsy who developed generalized seizures associated ...
Takayuki Mori, Hiroshi Terashima, Yu kakimoto, Mitsuhiro Kato, Shumpei Uchino   +4 more
wiley   +1 more source

Visualization of synaptotagmin I oligomers assembled onto lipid monolayers [PDF]

Proceedings of the National Academy of Sciences, 2003
Neuronal exocytosis is mediated by Ca 2+ -triggered rearrangements between proteins and lipids that result in the opening and dilation of fusion pores. Synaptotagmin I (syt I) is a Ca 2+ -sensing protein proposed to regulate fusion pore dynamics via Ca
Yi, Wu, Yuhong, He, Jihong, Bai, Shang-Rong, Ji, Ward C, Tucker, Edwin R, Chapman, Sen-Fang, Sui   +6 more
openaire   +2 more sources

Electrostatic regulation of the cis - and trans -membrane interactions of synaptotagmin-1

Scientific Reports, 2022
Abstract Synaptotagmin-1 is a vesicular protein and Ca 2+ sensor for Ca 2+ -dependent exocytosis. Ca 2+ induces synaptotagmin-1 binding to its own vesicle membrane, called the cis-
Houda Yasmine Ali Moussa, Yongsoo Park
openaire   +3 more sources