Results 41 to 50 of about 21,364,816 (201)
Calcium-dependent transmitter secretion from fibroblasts: Modulation by synaptotagmin I [PDF]
, 1995 Following endocytic uptake of acetylcholine (ACh), CHO fibroblasts exhibit Ca2+-dependent spontaneous quantal ACh release and depolarization-evoked ACh release, as detected by a whole-cell voltage-clamped myocyte in contact with the fibroblast.
Poo, Mu-ming +3 more
core +1 more source
Borna disease virus blocks potentiation of presynaptic activity through inhibition of protein kinase C signaling. [PDF]
PLoS Pathogens, 2006 Infection by Borna disease virus (BDV) enables the study of the molecular mechanisms whereby a virus can persist in the central nervous system and lead to altered brain function in the absence of overt cytolysis and inflammation.
Romain Volmer +2 more
doaj +2 more sources
Antioxidants, 2020 Prenatal stress (PNS) influences offspring neurodevelopment, inducing anxiety-like behavior and memory deficits. We investigated whether pretreatment of Bacopa monnieri extract (CDRI-08/BME) ameliorates PNS-induced changes in signaling molecules, and ...
Karunanithi Sivasangari +1 more
doaj +1 more source
The Energetics of the Denaturation of the C2A Domain of Synaptotagmin I [PDF]
Biophysical Journal, 2009 Thermodynamic parameters capture the averaged contribution to a system's energetics. In the case of binding proteins, such as synaptotagmin I, the first step toward addressing how and where the energy is distributed within that protein is to ascertain the magnitude of the interactions within that protein.
Gauer, Jacob W. +8 more
openaire +1 more source
Making Stem Cells Infarct Avid
Cell Transplantation, 2010 A major factor limiting the engraftment of transplanted stem cells after myocardial infarction is the low rate of retention in the infarcted site. Our long-term objective is to improve engraftment by enabling stem cells to recognize and bind infarcted ...
Ming Zhao Ph.D. +5 more
doaj +1 more source
BMC Genomics, 2007 Background Synaptotagmin genes are found in animal genomes and are known to function in the nervous system. Genes with a similar domain architecture as well as sequence similarity to synaptotagmin C2 domains have also been found in plant genomes.
Craxton Molly
doaj +1 more source
Journal of Biomedical Science, 2010 Background Akt regulates various cellular processes, including cell growth, survival, and metabolism. Recently, Akt's role in neurite outgrowth has also emerged. We thus aimed to identify neuronal function-related genes that are regulated by Akt. Methods
Kim Chul +5 more
doaj +1 more source
Structural basis of human PDZD8–Rab7 interaction for the ER-late endosome tethering
Scientific Reports, 2021 The membrane contact sites (MCSs) between the ER and late endosomes (LEs) are essential for the regulation of endosomal protein sorting, dynamics, and motility.
Haider Khan +3 more
doaj +1 more source
Frontiers in Pharmacology, 2022 Opioids, such as morphine, are used in clinical settings for the management of acute and chronic pain. However, long-term use of morphine leads to antinociceptive tolerance and hypersensitivity. The cellular and molecular mechanisms of morphine tolerance
Yusuke Ohashi +5 more
doaj +1 more source
Key determinants of the dual clamp/activator function of Complexin
eLifeComplexin determines magnitude and kinetics of synchronized secretion, but the underlying molecular mechanisms remained unclear. Here, we show that the hydrophobic face of the amphipathic helix at the C-terminus of Complexin II (CpxII, amino acids 115 ...
Mazen Makke +6 more
doaj +1 more source