Results 31 to 40 of about 21,364,816 (201)
Synaptotagmin V: a novel synaptotagmin isoform expressed in rat brain [PDF]
, 1995 Regulated Ca2+-dependent release of transmitters from synaptic vesicles is an important characteristic of chemical neurotransmission. Synaptotagmins are abundant synaptic vesicle transmembrane proteins that probably function as Ca2+ sensors.
Michel Goedert +3 more
core +1 more source
KIF1A-Associated Neurological Disorder: An Overview of a Rare Mutational Disease
Pharmaceuticals, 2023 KIF1A-associated neurological diseases (KANDs) are a group of inherited conditions caused by changes in the microtubule (MT) motor protein KIF1A as a result of KIF1A gene mutations.
Ayushi Nair +8 more
doaj +1 more source
Neuromodulation Induced by Sitagliptin: A New Strategy for Treating Diabetic Retinopathy
Biomedicines, 2021 Diabetic retinopathy (DR) involves progressive neurovascular degeneration of the retina. Reduction in synaptic protein expression has been observed in retinas from several diabetic animal models and human retinas.
Hugo Ramos +6 more
doaj +1 more source
Frontiers in Neuroscience, 2018 Chronic stress is a contributing risk factor in the pathogenesis of depression. Although the mechanisms are multifaceted, the relationship can be ascribed partly to stress-related alterations in immune activation and brain plasticity.
Yin-xiu Han +18 more
doaj +1 more source
Synaptotagmin I is essential for Ca2+-independent release of neurotransmitter induced by α-latrotoxin [PDF]
, 1994 α-Latrotoxin causes massive release of norepinephrine from clonal rat pheochromocytoma PC12 cells, in the absence of external Ca2+, by an unknown mechanism.
Takahashi, Masami +11 more
core +1 more source
Domain structure of synaptotagmin (p65) [PDF]
, 1991 Synaptotagmin (p65) is an abundant and evolutionarily conserved protein of synaptic vesicles that contains two copies of an internal repeat homologous to the regulatory region of protein kinase C.
Perin, M. S. +3 more
core +4 more sources
Pharmaceuticals, 2022 Alzheimer’s disease (AD) seriously endangers the health and life of elderly individuals worldwide. However, despite all scientific efforts, at the moment there are no effective clinical treatment options for AD.
Jingyun Liu +9 more
doaj +1 more source
Presynaptic Trafficking of Synaptotagmin I Is Regulated by Protein Palmitoylation [PDF]
Journal of Biological Chemistry, 2004 Protein palmitoylation plays a critical role in sorting and targeting of several proteins to pre- and postsynaptic sites. In this study, we have analyzed the role of palmitoylation in trafficking of synaptotagmin I and its modulation by synaptic activity.
Rujun, Kang +6 more
openaire +2 more sources
Cells, 2022 Cytochrome P450 (CYP) gene mutations are a common predisposition associated with glaucoma. Although the molecular mechanisms are largely unknown, omega-3 polyunsaturated fatty acids (ω-3 PUFA) and their CYP-derived bioactive mediators play crucial roles ...
Natarajan Perumal +3 more
doaj +1 more source
Vesicle-associated Membrane Protein-2/Synaptobrevin Binding to Synaptotagmin I Promotes O-Glycosylation of Synaptotagmin I [PDF]
Journal of Biological Chemistry, 2002 Synaptotagmin I (Syt I), an evolutionarily conserved integral membrane protein of synaptic vesicles, is now known to regulate Ca2+-dependent neurotransmitter release. Syt I protein should undergo several post-translational modifications before maturation and subsequent functioning on synaptic vesicles (e.g.
openaire +2 more sources