Results 11 to 20 of about 21,364,816 (201)
Synaptotagmin I-ΔC2B. A novel synaptotagmin isoform with a single C2 domain in the bovine adrenal medulla [PDF]
Biochimica et Biophysica Acta (BBA) - Biomembranes, 2002 Synaptotagmin I is a 65 kDa type 1 membrane glycoprotein found in secretory organelles that plays a key role in regulated exocytosis. We have characterised two forms (long and short) of synaptotagmin I that are present in the bovine adrenal medulla. The long form is a type I integral membrane protein which has two cytoplasmic C2 domains and corresponds
Hewitt, Eric W. +4 more
openaire +3 more sources
Upregulation of synaptotagmin IV inhibits transmitter release in PC12 cells with targeted synaptotagmin I knockdown [PDF]
BMC Neuroscience, 2010 Background The function of synaptotagmins (syt) in Ca2+-dependent transmitter release has been attributed primarily to Ca2+-dependent isoforms such as syt I.
Moore-Dotson Johnnie M +2 more
doaj +3 more sources
Synaptotagmin I functions as a calcium regulator of release probability
Nature, 2001 In all synapses, Ca2+ triggers neurotransmitter release to initiate signal transmission. Ca2+ presumably acts by activating synaptic Ca2+ sensors, but the nature of these sensors--which are the gatekeepers to neurotransmission--remains unclear. One of the candidate Ca2+ sensors in release is the synaptic Ca2+-binding protein synaptotagmin I.
Fernandez-Chacon, R +9 more
openaire +6 more sources
Synaptotagmin gene content of the sequenced genomes [PDF]
BMC Genomics, 2004 Background Synaptotagmins exist as a large gene family in mammals. There is much interest in the function of certain family members which act crucially in the regulated synaptic vesicle exocytosis required for efficient neurotransmission.
Craxton Molly
doaj +5 more sources
The Extended Synaptotagmins of Physcomitrium patens
PlantsMembrane contact sites (MCSs) between the endoplasmic reticulum and the plasma membrane enable the transport of lipids without membrane fusion. Extended Synaptotagmins (ESYTs) act at MCSs, functioning as tethers between two membrane compartments.
Alexander Kaier, Maria Ntefidou
doaj +4 more sources
Synaptotagmin I Functions as a Calcium Sensor to Synchronize Neurotransmitter Release [PDF]
Neuron, 2002 To characterize Ca(2+)-mediated synaptic vesicle fusion, we analyzed Drosophila synaptotagmin I mutants deficient in specific interactions mediated by its two Ca(2+) binding C2 domains. In the absence of synaptotagmin I, synchronous release is abolished and a kinetically distinct delayed asynchronous release pathway is uncovered.
Yoshihara, Motojiro, Littleton, J.Troy
openaire +4 more sources
Journal of Vision, 2003 Synaptic vesicle exocytosis is triggered by rises in calcium up to 100 microM at the site of vesicle fusion. The synaptic vesicle proteins synaptotagmin 1 and 2 (Syt I and Syt II) bind calcium at similarly high concentrations and have been proposed as the calcium sensors for fast neurotransmitter release.
Berntson Eichner, Amy +1 more
openaire +4 more sources
Synaptotagmin I: Palmitoylierung und intrazelluläre Prozessierung
, 2001 Titel 1 Einführung in die Thematik 1 2 Problemstellung 16 3 Material und Methoden 17 4 Ergebnisse 38 5 Diskussion 56 6 Zusammenfassung 68 7 Summary 70 8 Literatur ...
Heindel, Ulrich Christian
openaire +2 more sources
High affinity interactions of Pb2+ with synaptotagmin I. [PDF]
Metallomics, 2018 ABSTRACT Lead (Pb) is a potent neurotoxin that disrupts synaptic neurotransmission. We report that Synaptotagmin I (SytI), a key regulator of Ca 2+ -evoked neurotransmitter release, has two high-affinity Pb 2+ binding sites that belong to its ...
Katti S +5 more
europepmc +5 more sources
Allostery and instability in the functional plasticity of synaptotagmin I. [PDF]
Commun Integr Biol, 2013 Synaptotagmin I (Syt I) is the calcium ion sensor for regulated release of neurotransmitter. How Syt I mediates this cellular event has been a question of extensive study for decades and yet, a clear understanding of the protein's diverse functionality has remained elusive. Using tools of thermodynamics, we have identified two intrinsic properties that
Fealey ME, Hinderliter A.
europepmc +4 more sources