Pull-down combined with proteomic strategy reveals functional diversity of synaptotagmin I [PDF]
PeerJ, 2017 Synaptotagmin I (Syt I) is most abundant in the brain and is involved in multiple cellular processes. Its two C2 domains, C2A and C2B, are the main functional regions.
Tianyao Guo +6 more
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Negative coupling as a mechanism for signal propagation between C2 domains of synaptotagmin I. [PDF]
PLoS ONE, 2012 Synaptotagmin I (Syt I) is a vesicle-localized protein implicated in sensing the calcium influx that triggers fast synchronous release of neurotransmitter.
Michael E Fealey +6 more
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Correction: Yamada et al. Extended-Synaptotagmin 1 Enhances Liver Cancer Progression Mediated by the Unconventional Secretion of Cytosolic Proteins. Molecules 2023, 28, 4033 [PDF]
MoleculesFollowing publication, concerns were raised regarding the peer-review process related to the publication of this article [...]
Kohji Yamada +12 more
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Guiding AlphaFold to predict how Munc13-1 opens Syntaxin-1. [PDF]
FEBS Open BioThe syntaxin‐1 Habc‐domain (orange), linker (pink) and SNARE motif (yellow) form a closed conformation that binds to Munc18‐1 (violet) and is opened by the Munc13‐1 MUN domain (cyan) to form the SNARE complex that triggers neurotransmitter release.
Chattopadhyay M, Xu J, Rizo J.
europepmc +2 more sources
Synaptotagmin 1 and Synaptotagmin 7 promote MR1-mediated presentation of Mycobacterium tuberculosis antigens [PDF]
eLifeMycobacterium tuberculosis (Mtb) is an intracellular pathogen that can be sensed by T cells, which are essential for the control of infection. In comparison to viral infections, Mtb antigens are relatively limited and hence, challenging to sample ...
Se-Jin Kim +6 more
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Synaptotagmin I regulates patterned spontaneous activity in the developing rat retina via calcium binding to the C2AB domains. [PDF]
PLoS ONE, 2012 BACKGROUND: In neonatal binocular animals, the developing retina displays patterned spontaneous activity termed retinal waves, which are initiated by a single class of interneurons (starburst amacrine cells, SACs) that release neurotransmitters. Although
Chung-Wei Chiang +8 more
doaj +2 more sources
Differential roles for snapin and synaptotagmin in the synaptic vesicle cycle. [PDF]
PLoS ONE, 2013 Evoked synaptic transmission is dependent on interactions between the calcium sensor Synaptotagmin I and the SNARE complex, comprised of Syntaxin, SNAP-25, and Synaptobrevin.
Szi-Chieh Yu +4 more
doaj +1 more source
Synaptotagmin 13 Is Highly Expressed in Estrogen Receptor-Positive Breast Cancer
Current Oncology, 2021 Background: Accumulating evidence indicates tumor-promoting roles of synaptotagmin 13 (SYT13) in several cancers; however, no studies have investigated its expression in breast cancer (BC).
Takahiro Ichikawa +10 more
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Cell Reports, 2023 Summary: Synaptotagmin III (Syt3) is a Ca2+-dependent membrane-traffic protein that is highly concentrated in synaptic plasma membranes and affects synaptic plasticity by regulating post-synaptic receptor endocytosis.
Haifeng Lu +12 more
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Huperzine A and Its Neuroprotective Molecular Signaling in Alzheimer’s Disease
Molecules, 2021 Huperzine A (HupA), an alkaloid found in the club moss Huperzia serrata, has been used for centuries in Chinese folk medicine to treat dementia.
María Jesús Friedli +1 more
doaj +1 more source