Results 21 to 30 of about 21,364,816 (201)
Synaptotagmin gene content of the sequenced genomes [PDF]
, 2011 Background Synaptotagmins exist as a large gene family in mammals. There is much interest in the function of certain family members which act crucially in the regulated synaptic vesicle exocytosis required for efficient neurotransmission.
core +10 more sources
The cytoplasmic domain of rat synaptotagmin I enhances synaptic transmission. [PDF]
Cell Mol Neurobiol, 2014 Synaptotagmin, an integral membrane protein of synaptic vesicles, functions as a calcium sensor in the temporal control of neurotransmitter release. Although synaptotagmin facilitates lipid membrane fusion in biochemical experiments, overexpression of synaptotagmin inhibits neurotransmission.
Hua SY, Syed A, Aupérin TC, Tong L.
europepmc +3 more sources
Cis - and trans -membrane interactions of synaptotagmin-1 [PDF]
Proceedings of the National Academy of Sciences, 2012 In neurotransmission synaptotagmin-1 tethers synaptic vesicles to the presynaptic plasma membrane by binding to acidic membrane lipids and SNAREs and promotes rapid SNARE-mediated fusion upon Ca 2+ triggering.
Vennekate, W. +6 more
openaire +4 more sources
Toxins, 2020 Botulinum neurotoxins (BoNTs) can be used therapeutically to treat a wide range of neuromuscular and neurological conditions. A collection of natural BoNT variants exists which can be classified into serologically distinct serotypes (BoNT/B), and further
Jonathan R. Davies +2 more
doaj +1 more source
Insects, 2021 The decreasing number of bees is a global ecological problem. With the advancement of agricultural modernisation, the large-scale use of neonicotinoid insecticides is one of the main factors leading to the decline of bees.
Yuhao Zhang +4 more
doaj +1 more source
Mechanism for calcium ion sensing by the C2A domain of synaptotagmin I. [PDF]
Biophys J, 2012 The C2A domain is one of two calcium ion (Ca(2+))- and membrane-binding domains within synaptotagmin I (Syt I), the identified Ca(2+) sensor for regulated exocytosis of neurotransmitter. We propose that the mechanistic basis for C2A's response to Ca(2+) and cellular function stems from marginal stability and ligand-induced redistributions of protein ...
Gauer JW +6 more
europepmc +4 more sources
Retinal glycoprotein enrichment by concanavalin a enabled identification of novel membrane autoantigen synaptotagmin-1 in equine recurrent uveitis. [PDF]
, 2012 Complete knowledge of autoantigen spectra is crucial for understanding pathomechanisms of autoimmune diseases like equine recurrent uveitis (ERU), a spontaneous model for human autoimmune uveitis. While several ERU autoantigens were identified previously,
Cornelia A. Deeg +23 more
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Profiling trait anxiety: transcriptome analysis reveals cathepsin B (Ctsb) as a novel candidate gene for emotionality in mice. [PDF]
, 2011 Behavioral endophenotypes are determined by a multitude of counteracting but precisely balanced molecular and physiological mechanisms. In this study, we aim to identify potential novel molecular targets that contribute to the multigenic trait "anxiety".
Holsboer, Florian +83 more
core +1 more source
Insects, 2020 The most common type of RNA editing in metazoans is the deamination of adenosine into inosine (A-to-I) catalyzed by the adenosine deaminase acting on the RNA (ADAR) family of proteins.
Chongjun Ye +6 more
doaj +1 more source
EJNMMI Research, 2020 Introduction Trialing novel cancer therapies in the clinic would benefit from imaging agents that can detect early evidence of treatment response. The timing, extent and distribution of cell death in tumors following treatment can give an indication of ...
Flaviu Bulat +11 more
doaj +1 more source