Results 51 to 60 of about 21,364,816 (201)

Reconstituted synaptotagmin I mediates vesicle docking, priming, and fusion. [PDF]

J Cell Biol, 2011
The synaptic vesicle protein synaptotagmin I (syt) promotes exocytosis via its ability to penetrate membranes in response to binding Ca2+ and through direct interactions with SNARE proteins. However, studies using full-length (FL) membrane-embedded syt in reconstituted fusion assays have yielded conflicting results, including a lack of effect, or even ...
Wang Z, Liu H, Gu Y, Chapman ER.
europepmc   +4 more sources

Synaptotagmin in Ca2+-Dependent Exocytosis Dynamic Action in a Flash [PDF]

, 2003
Synaptotagmins have been the popular candidates for the Ca2+ sensor that couples local rise in Ca2+ to neurotransmitter release. Studies in worm, fly, and mouse corroborate the likely role for synaptotagmin I, the best-studied synaptotagmin prototype, as
Yukiko Goda, Tokuoka, Hirofumi, Hirofumi Tokuoka, Goda, Yukiko   +3 more
core   +1 more source

Developmental Regulation of Synaptotagmin I, II, III, and IV mRNAs in the Rat CNS

, 1997
Synaptotagmin I is an abundant synaptic vesicle protein that has an essential function in mediating Ca2+-triggered neurotransmitter release. We have analyzed the distribution of four neural synaptotagmin isoforms during postnatal development of the rat ...
Frédérique Berton, Béatrice Marquèze, Cécile Iborra, Michael J. Seagar, Jeanne-Andrée Boudier   +4 more
core   +1 more source

Synaptotagmin-1 and Synaptotagmin-7 Trigger Synchronous and Asynchronous Phases of Neurotransmitter Release [PDF]

, 2013
SummaryIn forebrain neurons, knockout of synaptotagmin-1 blocks fast Ca2+-triggered synchronous neurotransmitter release but enables manifestation of slow Ca2+-triggered asynchronous release.
Südhof, Thomas C., Malenka, Robert C., Yang, Xiaofei, Bacaj, Taulant, Wu, Dick, Xu, Wei, Zhou, Peng, Morishita, Wade   +7 more
core   +1 more source

APP is cleaved by Bace1 in pre-synaptic vesicles and establishes a pre-synaptic interactome, via its intracellular domain, with molecular complexes that regulate pre-synaptic vesicles functions.

PLoS ONE, 2014
Amyloid Precursor Protein (APP) is a type I membrane protein that undergoes extensive processing by secretases, including BACE1. Although mutations in APP and genes that regulate processing of APP, such as PSENs and BRI2/ITM2B, cause dementias, the ...
Dolores Del Prete, Franco Lombino, Xinran Liu, Luciano D'Adamio, Luciano D'Adamio   +4 more
doaj   +1 more source

A meta-analysis of genome-wide data from five European isolates reveals an association of COL22A1, SYT1, and GABRR2 with serum creatinine level

BMC Medical Genetics, 2010
Background Serum creatinine (SCR) is the most important biomarker for a quick and non-invasive assessment of kidney function in population-based surveys.
Oostra Ben A, Meitinger Thomas, Boban Mladen, Hastie Nick, Campbell Susan, Schreiber Stefan, Gnewuch Carsten, Zemunik Tatijana, Zgaga Lina, Nöthlings Ute, Kolcic Ivana, Ellinghaus David, Polasek Ozren, Isaacs Aaron, Melville Scott A, Wild Sarah H, Johansson Asa, Aulchenko Yurii S, Franke Andre, Hayward Caroline, Vitart Veronique, De Grandi Alessandro, Pattaro Cristian, Riegler Peter, Minelli Cosetta, Wright Alan F, Campbell Harry, van Duijn Cornelia M, Gyllensten Ulf, Wilson James F, Krawczak Michael, Rudan Igor, Pramstaller Peter P   +32 more
doaj   +1 more source

Adenosine triphosphate as a modulator of protein interactions and stability

FEBS Open Bio, EarlyView.
ATP is best known as the cell's energy currency, but it also shapes how proteins fold, interact, aggregate and form biomolecular condensates. This review explains the emerging physical principles behind these effects, including weak binding to charged protein regions, magnesium‐dependent behaviour and concentration‐dependent control of protein ...
Shuyuan Tan, Robin Curtis
wiley   +1 more source

Region Specific miRNA–mRNA Networks in Gray and White Matter Lesions of Progressive Multiple Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Multiple sclerosis (MS) is a neurodegenerative demyelinating disease of the central nervous system. This study aimed to identify micro‐RNA (miRNA)–mRNA regulatory networks underlying region‐specific molecular mechanisms in white matter and gray matter lesions in progressive MS.
Adya Sapra, Nagendra K. Rai, Timothy D. Niepokny, Haley Courtney, Ajai Tripathi, Ranjan Dutta   +5 more
wiley   +1 more source

Synaptotagmin I and IV define distinct populations of neuronal transport vesicles.

, 2017
Mammalian synaptotagmins constitute a multigene family of at least 11 membrane proteins. We have characterized synaptotagmin IV using antibodies directed against the C2A domain of the protein.
Dargent, Bénédicte, Seagar, Michael, Berton, Frédérique, Fukuda, Mitsunori, Marquèze, Béatrice, Cornet, Véronique, Garrido Jurado, Juan José, Iborra, Cécile   +7 more
core   +1 more source

Early Retinal UCHL1 Dysregulation Coupled With Synaptic Loss Reflects Alzheimer's Disease Severity

Advanced Science, EarlyView.
This study identifies synapse‐enriched deubiquitinase UCHL1 as an early Aβ‐responsive regulator of retinal synaptopathy in Alzheimer's disease. Retinal UCHL1 loss accompanies excitatory synapse degeneration, p75NTR activation, and neuroinflammation, and predicts Braak stage and cognitive decline. Aβ42 fibrils trigger synaptic and UCHL1 depletion before
Altan Rentsendorj, Jean‐Philippe Vit, Alexandre Hutton, Yosef Koronyo, Saba Shahin, Edward Robinson, Ernesto Barron, Anthony Rodriguez, Ousman Jallow, Julia Sheyn, Bhakta Prasad Gaire, Lalita Subedi, Miyah R. Davis, Barathan Gnanabharathi, Alexander V. Ljubimov, Stuart L. Graham, Vivek K. Gupta, Mehdi Mirzaei, Debra Hawes, Katlin Silm, Keith L. Black, Lon S. Schneider, Alfredo A. Sadun, Jesse G. Meyer, Dieu‐Trang Fuchs, Maya Koronyo‐Hamaoui   +25 more
wiley   +1 more source