Results 91 to 100 of about 21,364,816 (201)

Kinetics of Synaptotagmin Responses to Ca2+ and Assembly with the Core SNARE Complex onto Membranes [PDF]

, 1999
The synaptic vesicle protein synaptotagmin I binds Ca2+ and is required for efficient neurotransmitter release. Here, we measure the response time of the C2 domains of synaptotagmin to determine whether synaptotagmin is fast enough to function as a Ca2 ...
Lewis, Jessica L, Davis, Anson F, Wolowick, Mark J, Bai, Jihong, Fasshauer, Dirk, Chapman, Edwin R   +5 more
core   +1 more source

Increased expression of SNARE proteins and synaptotagmin IV in islets from pregnant rats and in vitro prolactin-treated neonatal islets

Biological Research, 2006
During pregnancy and the perinatal period of life, prolactin (PRL) and other lactogenic substances induce adaptation and maturation of the stimulus-secretion coupling system in pancreatic β-cells. Since the SNARE molecules, SNAP-25, syntaxin 1, VAMP-
DANIEL A CUNHA, MARIA EC AMARAL, CAROLINA PF CARVALHO, CARLA B COLLARES-BUZATO, EVERARDO M CARNEIRO, ANTONIO C BOSCHERO   +5 more
doaj  

Altered mechanisms underlying the abnormal glutamate release in amyotrophic lateral sclerosis at a pre-symptomatic stage of the disease

Neurobiology of Disease, 2016
Abnormal Glu release occurs in the spinal cord of SOD1G93A mice, a transgenic animal model for human ALS. Here we studied the mechanisms underlying Glu release in spinal cord nerve terminals of SOD1G93A mice at a pre-symptomatic disease stage (30 days ...
Tiziana Bonifacino, Laura Musazzi, Marco Milanese, Mara Seguini, Antonella Marte, Elena Gallia, Luca Cattaneo, Franco Onofri, Maurizio Popoli, Giambattista Bonanno   +9 more
doaj   +1 more source

Precision Chemistry for Protein Lysine Modification

Chemistry – A European Journal, Volume 32, Issue 34, 11 September 2026.
Selective modification of lysine residues is challenging due to their similar intrinsic reactivity. Inspired by enzymatic recognition, ligand‐guided electrophiles enable site‐selective labeling and functionalization, while ligand‐guided catalyses achieve regioselective installation of bio‐relevant post‐translational modifications.
Mayu Onoda, Motomu Kanai
wiley   +1 more source

N-glycosylation is essential for vesicular targeting of synaptotagmin 1 [PDF]

, 2004
Synaptotagmins 1 and 7 are candidate Ca2+ sensors for exocytosis localized to synaptic vesicles and plasma membranes, respectively. We now show that the N-terminal intraluminal sequence of synaptotagmin 1, when transplanted onto synaptotagmin 7 ...
Maximov, A., Rhee, Jeong-Seop, Rosenmund, Christian, Suedhof, T., Mashimo, T., Mashimo, Tomoyuki, Han, W., Lao, Ye, Rhee, J., Suedhof, T. C., Han, Weiping, Rhee, J. S., Lao, Y., Südhof, Thomas C., Rosenmund, C., Han, W. P., Maximov, Anton   +16 more
core   +1 more source

Inositol pyrophosphate kinases in health and disease

FEBS Letters, Volume 600, Issue 17, Page 2379-2396, September 2026.
In mammalian cells, IP6Ks and PPIP5Ks are the key kinases synthesizing the inositol pyrophosphates 5PP‐InsP5 and InsP8. They are essential for early development but also mediate age‐related diseases, including metabolic disorders, cardiovascular diseases, neurodegenerative diseases, and cancers.
Changchang Xing, Chao Wang, Yuanyuan Chen, Weiwei Cheng, Zhaolei Jiang, Alex F. Chen, Chenglai Fu   +6 more
wiley   +1 more source

Inositol hexakisphosphate (InsP6) can weaken the Ca2+-dependent membrane binding of C2AB domain of synaptotagmin I [PDF]

, 2002
The synaptic vesicle protein synaptotagmin I has been proposed to serve as a Ca2+ sensor for rapid exocytosis. In the present work, two fragments of the large cytoplasmic domain of synaptotagmin I, C2A and C2AB, were compared by combining surface plasmon
Ying-Jie Lu, Sen-fang Sui, Lu, Ying-Jie, Yuhong He, Sui, Sen-fang, He, Yuhong   +5 more
core   +1 more source

Synaptotagmin-7 outperforms synaptotagmin-1 to promote the formation of large, stable fusion pores via robust membrane penetration

, 2023
Synaptotagmin-1 and synaptotagmin-7 are two prominent calcium sensors that regulate exocytosis in neuronal and neuroendocrine cells. Upon binding calcium, both proteins partially penetrate lipid bilayers that bear anionic phospholipids, but the specific ...
Kevin C. Courtney, Edwin R. Chapman, Lanxi Wu, Qiang Cui, Debasis Das, Taraknath Mandal, Nikunj Mehta, Yueqi Li   +7 more
core   +1 more source

Ca2+-independent syntaxin binding to the C2B effector region of synaptotagmin [PDF]

, 2012
Although synaptotagmin I, which is a calcium (Ca2+)-binding synaptic vesicle protein, may trigger soluble N-ethylmaleimide-sensitive factor attachment protein receptor (SNARE)-mediated synaptic vesicle exocytosis, the mechanisms underlying the ...
Atsushi Fujimura, Koichiro Suzuki, Toshio Masumoto, Tei-ichi Nishiki, Fujimura, Atsushi, Tomizawa, Kazuhito, Michiue, Hiroyuki, Nishiki, Tei-ichi, Hideki Matsui, Iori Ohmori, Masumoto, Toshio, Suzuki, Koichiro, Kazuhito Tomizawa, Ohmori, Iori, Matsui, Hideki, Hiroyuki Michiue   +15 more
core   +2 more sources

Genetic and molecular evidence linking CTSH to Alzheimer's disease pathophysiology

Alzheimer's &Dementia, Volume 22, Issue 9, September 2026.
Abstract INTRODUCTION Lysosomal dysfunction contributes to Alzheimer's disease (AD) by impairing protein clearance and promoting neuroinflammation. Cathepsin H (CTSH), a lysosomal protease, recently emerged as a protective AD locus. We investigated how CTSH is regulated and how it influences early AD pathophysiology.
Cynthia Picard, Gabriel Aumont‐Rodrigue, Isabel Sarty, Julia Loncke, Mélissa Savard, Laurence Maligne‐Bruneau, Judes Poirier, for the PREVENT‐AD research group   +7 more
wiley   +1 more source