Results 161 to 170 of about 21,364,816 (201)

Synaptotagmin I, a Ca2+ sensor for neurotransmitter release

Trends in Neurosciences, 2003
The discovery that Ca(2+) triggers rapid neurotransmitter release has prompted the search for the Ca(2+) sensor. There is now general agreement that the vesicle-associated Ca(2+)-binding protein, synaptotagmin I, is required for the tight temporal coupling between Ca(2+) influx and synaptic vesicle fusion.
Tong Wey, Koh, Hugo J, Bellen
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An antibody to synaptotagmin I facilitates synaptic transmission

European Journal of Neuroscience, 2007
AbstractProper functioning of the nervous system requires precise control of neurotransmitter release. Synaptotagmin, a synaptic vesicle protein, is crucial for the temporal control of neurotransmitter release. The mechanism of synaptotagmin function is still under debate.
Shao-Ying, Hua, Merilee A, Teylan, Aylin, Cimenser   +2 more
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Identification and characterization of a novel C2B splice variant of synaptotagmin I. [PDF]

Journal of Neurochemistry, 2004
AbstractWe have identified an alternatively spliced form of synaptotagmin I in Aplysia neurons. This isoform, synaptotagmin I C2B‐β, is generated by alternative exon usage in the C2B domain leading to nine amino acid changes in the C2B sequence from the previously characterized synaptotagmin I, now designated as synaptotagmin I C2B‐α.
Wayne S Sossin, Vincent F Castellucci
exaly   +3 more sources

Variations of synaptotagmin I, synaptotagmin IV and synaptophysin mRNA levels during the estrous cycle

Experimental Neurology, 1999
Periodic changes in ovarian steroid levels during fertility cycles affect learning both in humans and in rats in parallel with electrophysiological and morphological fluctuations in selective neuronal populations. In particular, during the estrous cycle of the female rat, hippocampal CA1 region undergoes cyclic modifications in synaptic density.
M. CRISPINO, STONE D. J., WEI M., ANDERSON C. P., TOCCO G., FINCH C. E., BAUDRY M.   +6 more
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Lipid rafts association of synaptotagmin I on synaptic vesicles

Biochemistry (Moscow), 2008
We confirmed the raft association of synaptotagmin I (syt I) in synaptic vesicles by sucrose density gradient centrifugation, cholesterol depletion, and temperature dependence, and Ca2+ was found to positively regulate this association. Furthermore, using syt I mutants we found that the transmembrane domain (TMD) of syt I plays an important role in ...
Ji-Hua, Lv, Li, He, Sen-Fang, Sui
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Disruption of a synaptotagmin (SYT14) associated with neurodevelopmental abnormalities

American Journal of Medical Genetics Part A, 2007
AbstractWe report cytogenetic and molecular studies of a de novo, apparently balanced t(1;3)(q32.1;q25.1) identified in a 12‐year‐old female (designated DGAP128) with cerebral atrophy, macrocephaly seizures, and developmental delay. A combination of fluorescence in situ hybridization (FISH) and Southern blot analysis demonstrated disruption of a ...
Fabiola, Quintero-Rivera, Alicia, Chan, Diana J, Donovan, James F, Gusella, Azra H, Ligon   +4 more
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Hemifusion arrest by complexin is relieved by Ca2+–synaptotagmin I

Nature Structural & Molecular Biology, 2006
Synaptic transmission relies on an exquisitely orchestrated series of protein-protein interactions. Here we show that fusion driven by neuronal SNAREs is inhibited by the regulatory protein complexin. Furthermore, inner-leaflet mixing is strongly impaired relative to total lipid mixing, indicating that inhibition by complexin arrests fusion at ...
Johanna R, Schaub, Xiaobing, Lu, Blair, Doneske, Yeon-Kyun, Shin, James A, McNew   +4 more
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Regulation of Synaptotagmin I Phosphorylation by Multiple Protein Kinases

Journal of Neurochemistry, 1999
Abstract : Synaptotagmin I has been suggested to function as a low‐affinity calcium sensor for calcium‐triggered exocytosis from neurons and neuroendocrine cells. We have studied the phosphorylation of synaptotagmin I by a variety of protein kinases in vitro and in intact preparations.
S, Hilfiker, V A, Pieribone, C, Nordstedt, P, Greengard, A J, Czernik   +4 more
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Detection of Apoptosis Using the C2A Domain of Synaptotagmin I

Bioconjugate Chemistry, 2004
Binding of annexin V or the C2A domain of synaptotagmin I to phosphatidylserine expressed on the surface of apoptotic cells can, when labeled with appropriate probe molecules, be used to detect the presence of apoptosis using radionuclide, magnetic resonance, and optical imaging techniques.
Hyo-Il, Jung, Mikko I, Kettunen, Bazbek, Davletov, Kevin M, Brindle   +3 more
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Synaptotagmins I and II in the developing rat auditory brainstem: Synaptotagmin I is transiently expressed in glutamate‐releasing immature inhibitory terminals

Journal of Comparative Neurology, 2011
AbstractThe lateral superior olive (LSO), a nucleus in the auditory brainstem, computes interaural intensity differences for sound localization by comparing converging excitatory and inhibitory inputs that carry tonotopically matched information from the two ears.
Alan P, Cooper, Deda C, Gillespie
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