Results 171 to 180 of about 21,364,816 (201)
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Drosophila synaptotagmin I null mutants survive to early adulthood
genesis, 2001AbstractSummary: Synaptotagmin is a synaptic vesicle protein required for efficient neurotransmitter release, yet its exact role in the synaptic vesicle cycle is unclear. Drosophila presents an ideal organism for studies aimed at determining the in vivo functions of proteins.
C A, Loewen, J M, Mackler, N E, Reist
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Clathrin light chain and synaptotagmin I in rat sympathetic neurons
Journal of the Autonomic Nervous System, 1997Clathrin light chain (clathrin LC) and synaptotagmin I in sympathetic neurons in rat superior cervical ganglia (SCG) were studied using immunofluorescence and confocal microscopy. The distributions of clathrin LC and synaptotagmin I were compared with that of tyrosine hydroxylase (TH) and neuropeptide Y (NPY) in double label experiments.
X E, Hou, J Y, Li, A, Dahlström
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Synaptic function modulated by changes in the ratio of synaptotagmin I and IV
Nature, 1999Communication within the nervous system is mediated by Ca2+-triggered fusion of synaptic vesicles with the presynaptic plasma membrane. Genetic and biochemical evidence indicates that synaptotagmin I may function as a Ca2+ sensor in neuronal exocytosis because it can bind Ca2+ and penetrate into lipid bilayers.
J T, Littleton +4 more
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Synaptotagmin I is necessary for compensatory synaptic vesicle endocytosis in vivo
Nature, 2003Neurotransmission requires a balance of synaptic vesicle exocytosis and endocytosis. Synaptotagmin I (Syt I) is widely regarded as the primary calcium sensor for synaptic vesicle exocytosis. Previous biochemical data suggest that Syt I may also function during synaptic vesicle endocytosis; however, ultrastructural analyses at synapses with impaired Syt
Poskanzer, K.E. +3 more
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Ca2+/phospholipid-binding and syntaxin-binding of native synaptotagmin I
Life Sciences, 1997Synaptotagmin, a synaptic vesicle protein endowed with multiple properties, is the putative calcium sensor in neuroexocytosis. Ca2+/phospholipid binding and syntaxin binding activity of synaptotagmin were previously investigated using recombinant fusion proteins.
M, Popoli +3 more
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Dopaminergic regulation of synaptotagmin I and IV mRNAs in hemiparkinsonian rats
NeuroReport, 2000Synaptotagmins (Syts) I and IV are synaptic proteins involved in the regulation of neurosecretion. Dopaminergic drugs have been shown to modulate their expression. Here we investigate whether dopaminergic regulation of syt I and syt IV expression could play a role in the hypersensitive striatum of rats with unilateral lesions of dopaminergic ...
G, Glavan +4 more
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Synaptotagmin I and II are present in distinct subsets of central synapses
Journal of Comparative Neurology, 2007AbstractSynaptotagmin 1 and 2 (syt 1, syt 2) are synaptic vesicle‐associated membrane proteins that act as calcium sensors for fast neurotransmitter release from presynaptic nerve terminals. Here we show that widely used monoclonal antibodies, mab 48 and znp‐1, stain nerve terminals in multiple species and, in mouse, recognize syt 1 and syt 2 ...
Michael A, Fox, Joshua R, Sanes
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Distinct developmental expression of synaptotagmin I and IX in the mouse brain
NeuroReport, 2006Synaptotagmin IX has been postulated to function as a major Ca2+ sensor for dense-core vesicle exocytosis in neuroendocrine cells. In this study, we investigated the subcellular localization and developmental expression profile of synaptotagmin IX in the mouse brain and found that it is mainly present in the dense-core vesicle fraction, which is devoid
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Synaptotagmin I, synaptobrevin II, and syntaxin I are coexpressed in rat and gerbil pinealocytes
Cell and Tissue Research, 1996Recent studies have shown that mammalian pinealocytes contain a compartment of synaptic-like microvesicles that may serve secretory functions; however, knowledge of the molecular composition of these microvesicles is still incomplete. Therefore, we have analyzed rat and gerbil pineal glands for the presence of synaptotagmin I, synaptobrevin I and II ...
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Genetic analysis of synaptotagmin 2 in spontaneous and Ca2+‐triggered neurotransmitter release
EMBO Journal, 2006Zhiping P. Pang +2 more
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