Results 81 to 90 of about 338,475 (243)

Targeting the CRYAB/β‐Catenin Axis with an MMP‐9‐Responsive Hydrogel Disrupts CTC Clusters to Suppress Progression of Hepatocellular Carcinoma after Radiofrequency Ablation

Advanced Science, EarlyView.
The graphical abstract illustrates that sublethal thermal stress after iRFA upregulates the chaperone CRYAB in residual HCC cells, which stabilizes β‐catenin and drives a dual pathological program, including EMT and N2‐TAN polarization, thereby leading to heterotypic CTC cluster formation. The MMP‐9‐responsive hydrogel (XB@Gel) delivers XAV‐939 and BMS‐
Hui Chen, Danni Yang, Songying Pi, Yuhan Liu, Hongbin Huang, Feile Ye, Yuhong Lin, Zhongzhen Su, Yongquan Huang   +8 more
wiley   +1 more source

Synergistic Toxicities from Multiple Therapies for Synchronous Malignancies. [PDF]

Case Rep Oncol, 2023
Patel SB, Butler K, Esther J, Tuan J.
europepmc   +1 more source

Ribonucleotides Amplify Mitochondrial DNA‐Driven cGAS–STING Activation via FdUMP‐ribonucleotide Hybrid Particles to Potentiate Chemoimmunotherapy

Advanced Science, EarlyView.
This work develops a metabolic sharing strategy that employs cytidine monophosphate (CMP) to competitively reprogram floxuridine (FUDR) pyrimidine metabolism in colorectal tumor cells. Elevated intracellular FdUMP induces nucleotide imbalance, drives mitochondrial DNA release and cGAS‐STING innate immune cascade activation, and potentiates robust ...
Chao Wang, Chenxuan Zhao, Yesong Yao, Zhiwen Zou, Anxin Shi, Zhuo Feng, Mingkang Yang, Yue Yu, Yang Liu, Xuehui Rui, Jinhui Wu   +10 more
wiley   +1 more source

Reverse-Link Performance of Synchronous DS-CDMA Systems in Dispersive Rician Multipath Fading Channels

, 2003
The reverse-link performance of synchronous DS-CDMA is investigated in Rician multipath fading environments. The numerical results show that the performance benefits of synchronous transmission depend on the specular path’s power as well as on the ...
Hwang, S.H., Hanzo, L.
core   +1 more source

Concomitant Malignancies of the Gall Bladder and Pancreas: A Synchronous Oncologic Challenge

Journal of Clinical and Diagnostic Research
Synchronous malignancies involving the pancreas and gallbladder are exceedingly rare and often diagnosed incidentally during surgical exploration. We report a case of a 60-year-old male who presented with obstructive jaundice, pruritus, and epigastric ...
Anuradha Dnyanmote, Vedanth Tirmanwar
doaj   +1 more source

Synchronous GISTs associated with multiple sporadic tumors: a case report

, 2017
Gastrointestinal stromal tumors (GISTs) are rare neoplasms, but they also represent the most common mesenchymal tumors of the gastrointestinal tract originating from the cell of Cajal. GIST incidence ranges around 1% of all gastrointestinal malignancies.
Danila Comandini, Azzurra Damiani, Alessandro Pastorino   +2 more
core   +1 more source

Multifunctional Nanovaccine‐Radiotherapy Synergy Drives Anti‐Tumor Immunity via Multi‐Cascade Cell Death for Pancreatic Cancer Therapy

Advanced Science, EarlyView.
Machine‐learning‐driven transcriptomic analysis identifies FSTL3 as a key tumor‐microenvironment regulator in desmoplastic pancreatic adenocarcinoma. A cRGD‐modified liposome co‐loading gemcitabine and siFSTL3 serves as an irradiation‐triggered in situ nanovaccine. It synergizes with radiotherapy to induce ferroptosis and immunogenic cell death through
Chengyi Huang, Yushu Han, Xiang Liu, Chuanhao Wang, Xiaofei Zhu, Di Chen, Yangyang Gong, Liang Chen, Wenjuan Chen, Zhenyuan Miao, Bufu Tang, Huojun Zhang   +11 more
wiley   +1 more source

The implications of an incidental chronic lymphocytic leukaemia in a resection specimen for colorectal adenocarcinoma

World Journal of Surgical Oncology, 2007
Background Colorectal cancer and B cell chronic lymphocytic leukaemia (CLL) have a significant incidence, which are increasing with the aging population.
Alberts Justin C, Dennis Robert J
doaj   +1 more source

Upadacitinib Restrains the Pathogenic Fitness of CD4+ T Cells and Aberrant B Cell Programming in Optic Neuritis

Advanced Science, EarlyView.
Single‐cell profiling and functional perturbation reveal coordinated JAK1‐pSTAT3 downstream programs in optic neuritis, including MCL1‐dependent fitness of pathogenic CD4+ Tem cells and glycolysis‐linked, cholesterol‐sensitive B‐cell responses associated with RORA. Upadacitinib disrupts this reciprocal T‐B‐cell circuit and alleviates neuroinflammation,
Gengchen Jiang, Qi Jiang, Lian Han, Yue Peng, Xingyu Liu, Tong Yang, Hao Huang, Jiaying Liu, Yuan Gao, Hui Yang, Wenjun Zou, Zhaohuai Li, Wenru Su   +12 more
wiley   +1 more source

Permanent Magnet minimization in PM-Assisted Synchronous Reluctance motors for wide speed range [PDF]

, 2013
This paper presents a technique to modify the rotor lamination of a permanent-magnet-assisted synchronous reluctance motor, in order to reduce the magnet volume with no side effect on performance.
Guglielmi, Paolo, Pellegrino, Gian-Mario Luigi, Vagati, Alfredo, Armando, Eric Giacomo, PELLEGRINO, GIAN - MARIO LUIGI, Boazzo, Barbara   +5 more
core   +1 more source