Results 61 to 70 of about 338,475 (243)

Adrenocortical Carcinoma and Synchronous Malignancies

Journal of Cancer, 2010
Objective: Adrenocortical carcinoma (ACC) is an aggressive tumor that accounts for 0.02% of all reported cancers. ACC commonly arises in a sporadic manner, but may also manifest as part of a familial syndrome. Regardless of the setting, ACC rarely arises
Marlon A. Guerrero, Electron Kebebew
doaj  

Rare synchronous presentation and development of retroperitoneal dedifferentiated liposarcoma and rectal adenocarcinoma

Human Pathology: Case Reports, 2019
Multiple primary malignancies may occur as synchronous or meta-synchronous tumors in 2–17% of patients. Most multiple primary cancers occur in different locations of the same organ or in other organs such as lung, kidney, prostate, and bone.
Cyrus Parsa, D.O, Robert Orlando, M.D., PhD, Krishna Narayanan, M.D., Umakant M. Khetan, M.D., Jin Guo, M.D., Ravin Rupani, M.D.   +5 more
doaj   +1 more source

Double Trouble – Synchronous Primary Malignant Neoplasms: A Case Report

The Annals of African Surgery, 2022
Synchronous primary malignancy (SPM) is rare. We herein present a case of gastric carcinoma (GC) and renal cell carcinoma (RCC) to highlight the fact that the occurrence of RCC as a synchronous tumor along with GC is rare and that a high index of ...
Amaranathan Anandhi , Sathasivam Sureshkumar , Deepak Barathi , Bheemanathi Hanuman Srinivasan , Vikram Kate   +4 more
doaj   +1 more source

Synergistic p53 Pathway Activation Through Sono‐Gene Therapy Induced by Ultrasound‐Triggered Theranostic Mesoporous Nanoparticles

Advanced Science, EarlyView.
Schematic representation of ultrasound‐mediated ICG/siCD24@MSN‐LCD from nanostructure to synergistic sono‐gene therapy. This nanoplatform targets ASGPR via the LCD shell, which dissociates to release loaded ICG and siCD24. The core mechanism involves ultrasound‐guided sonodynamic therapy by ICG and CD24 knockdown by siCD24, both activating the p53 axis
Yading Zhao, Lu Guo, Dandan Shi, Xiao Sun, Mengmeng Shang, Song Ning, Shuting Huang, Xiaoxuan Wang, Rui Liu, Yuye Fu, Suyun Li, Jie Li   +11 more
wiley   +1 more source

Metabolic Reprogramming in Glioblastoma Stem Cells Promotes Radiation Resistance Through a H3K18la/USP30/MBOAT2 Axis

Advanced Science, EarlyView.
LDHA‐driven lactate production in mesenchymal glioma stem cells promotes p300‐dependent H3K18 lactylation, activates USP30 transcription, and stabilizes MBOAT2 to remodel phosphatidylethanolamines toward ferroptosis‐resistant PE‐MUFA species. Disrupting this metabolic–epigenetic–lipid circuit enhances ferroptosis and sensitizes glioblastoma to ...
Zong Miao, Wei Gu, Yimin Ren, Chenfei Lu, Wanzhi Cai, Junnan Lu, Zhongyuan Bao, Yanan Zhou, Rong Li, Ke Jin, Chao Chen, Hongxiang Wang, Lei Xu, Juxiang Chen   +13 more
wiley   +1 more source

Impact of Synchronous Multiple Primary Malignant Tumors on Newly Diagnosed Hematological Malignancies [PDF]

, 2017
The existence of synchronous multiple primary malignant tumors was not a significant risk factor for patients with newly diagnosed hematological malignancies.
Kotaro Suzuki, Isamu Sugiura, Satoshi Nishiwaki, Shingo Okuno, Okuno, Shingo, Suzuki, Kotaro, Shingo Kurahashi, Kurahashi, Shingo, Sugiura, Isamu, Nishiwaki, Satoshi   +9 more
core   +1 more source

Synchronous multiple primary colorectal cancer in patients with extraintestinal malignancies

Сибирский онкологический журнал
Introduction. The incidence of colorectal cancer (CRC) is steadily increasing in Russia. Patients with cancers of extra-intestinal malignancies are at increased risk of developing CRC.
V. V. Podolskiy, E. A. Podolskaya
doaj   +1 more source

Blood Cell‐Camouflaged Liquid Metal Nanoconjugates Orchestrate Treg Depletion and STING‐Amplified Photothermal Immunity for Metastatic Triple‐Negative Breast Cancer Therapy

Advanced Science, EarlyView.
Whole‐blood biomimetic engineering transforms liquid metal nanoparticles into a tripartite immunotherapeutic platform that orchestrates regulatory T‐cell depletion, photothermal‐induced immunogenic cell death, and activation of the stimulator of interferon genes pathway.
Nina Sang, Eijiro Miyako
wiley   +1 more source

An Intravesical Akkermansia muciniphila‐Based Chemo‐Immunotherapeutic Platform for Bladder Cancer

Advanced Science, EarlyView.
Pasteurized Akkermansia muciniphila is engineered into an intravesical F127/doxorubicin platform that couples localized chemotherapy with immune remodeling. By inducing apoptosis, ferroptosis, and immunogenic cell death, this chemo‐immunotherapeutic system enhances dendritic‐cell maturation, antigen cross‐presentation, and tumor‐specific CD8+ T‐cell ...
Rongkang Li, Anguo Zhao, Qi Zhuang, Lei Peng, Rui Liang, Jiadong Zhao, Yang Liu, Dashi Deng, Peng Yu, Xiqi Peng, Shaohua Zhang, Song Wu   +11 more
wiley   +1 more source

Generation of the induced pluripotent stem cell line SHUTCMi001-A from a patient with double primary lung and colon cancers

Stem Cell Research
Patients with synchronous multiple primary malignancies often exhibit unique genetic susceptibility. Here, we generated the induced pluripotent stem cell (iPSC) line, SHUTCMi001-A, from a 70-year-old patient with double primary lung squamous cell ...
Jingyi Wei, Guanjin Wu, Chenbing Sun, Lijing Jiao, Ling Xu   +4 more
doaj   +1 more source