Results 71 to 80 of about 355,526 (241)

Bilateral Synchronous Testicular Seminoma in a Patient with Bilateral Cryptorchidism

Journal of Nepal Medical Association, 2014
Cryptorchidism is a known cause of testicular tumor. The incidence of testicular tumor is 11 times more in inguinal testes and 50 times more in intra-abdominal testes.
Dilasma Ghartimagar, Arnab Ghosh, Manish Krishna Shrestha, Duk Bahadur Chettri, Santosh Shrestha, Rishi Kumar Sherchan   +5 more
doaj   +3 more sources

Synchronous Bilateral Breast Cancer and Thymoma: A Rare Case of Multiple Primary Malignancies

Clinical Case Reports
Synchronous bilateral breast cancer and thymoma is rare, requiring vigilant surveillance and multidisciplinary management. This case highlights the importance of distinguishing multiple primary malignancies from metastases, emphasizing tailored ...
Gholamreza Toogeh, Saeid Haji Aghajani, Seyyed Taher Seyyed Mahmoudi, Masoud Mortezazadeh, Hamidreza Zarei, Aysan Nozheh   +5 more
doaj   +1 more source

Supramolecular Degraders: An Emerging Paradigm in Targeted Protein Degradation

Advanced Science, EarlyView.
Dynamic supramolecular assembly reshapes targeted protein degradation by coordinating modular degrader construction, delivery, functional integration, and intracellular assembly or activation across proteasomal, endosomal–lysosomal, and autophagy–lysosomal pathways.
Kongjun Liu, Xue Yuan, Yan Zhou, Rui Yuan, Shaocheng Xie, Yong Chen, Peiyi Wang, Jianmei Gao, Qihai Gong   +8 more
wiley   +1 more source

Defect‐Engineered BiO2‐X Nanosheets Mediate Sono‐Thermomechanical ECM Remodeling for Hepatocellular Carcinoma Immunotherapy

Advanced Science, EarlyView.
Herein, an ultrasound‐responsive BiO2‐X/siFn1 nanoplatform is developed to overcome anti‐PD‐1 resistance in hepatocellular carcinoma. Upon ultrasound irradiation, the platform downregulates fibronectin expression, while its sonothermal effect softens the dense extracellular matrix and activates antitumor immunity in the tumor microenvironment, thereby ...
Huimin Tian, Shen Zhang, Bolin Wu, Yichi Chen, Haitao Shang, Haoyan Tan, Chunyue Wang, Weichen Xu, Huixiong Xu, Haohao Yin, Wen Cheng   +10 more
wiley   +1 more source

Synchronous Primary Atypical Pulmonary Carcinoid and Cecal Adenocarcinoma: A Case Report

Acta Medica Bulgarica
Pulmonary carcinoid tumors are a rare subgroup of neuroendocrine lung neo-plasms, accounting for approximately 1-2% of all primary lung cancers. The occurrence of synchronous primary malignancies involving pulmonary carcinoid and colorectal adeno ...
Gergov G., Alexieva M., Mekov E., Yanev N., Petkov R., Yankov G.   +5 more
doaj   +1 more source

DIXDC1 Promotes Lymphatic Metastasis and Resistance to Cuproptosis in Bladder Cancer Through Mediating DLAT

Advanced Science, EarlyView.
DIXDC1 drives bladder cancer progression by binding and stabilizing DLAT. This axis enhances NEK7 and CCNE2 mRNA stability to promote proliferation and lymphatic metastasis, while limiting copper‐induced DLAT oligomerization to reduce cuproptosis sensitivity, identifying DIXDC1 as a potential target linking metastasis with cuproptosis resistance ...
Hongqiong Li, Liang Cheng, Xiaole Lu, Haonan Dong, Shi Fu, Hongjin Shi, Mingsheng Liu, Chenwei Yang, Yuhang Huang, Zehua Chen, Yawei Zhang, Kaiwen Jie, Xiaoyue Zhang, Xiang Kui, Xinni Ye, Siting Chen, Xu Chen, Haifeng Wang   +17 more
wiley   +1 more source

FOXP1 Knockdown Reprograms Th9 CAR‐T Cells to Overcome Antigen Escape

Advanced Science, EarlyView.
FOXP1 knockdown enhances Th9 CAR‐T cell function by promoting IL‐9 production, effector activation, and reduced exhaustion. Reprogrammed Th9 CAR‐T cells strengthen direct tumor killing and activate endogenous antitumor immunity through dendritic cells and CD8+ T cells, thereby suppressing both antigen‐positive and antigen‐loss tumor growth and ...
Yihan Zhu, Xingwei Xie, Xiaohuan Wu, Suidong Ouyang, Yang Zhou, Kang Wen, Yutong Zhong, Yuyang Chen, Handuo Wang, Yuan Gao, Ling Jiang, Hui Li, Wenli Zhao, Abai Xu, Enguang Bi   +14 more
wiley   +1 more source

Permanent Magnet minimization in PM-Assisted Synchronous Reluctance motors for wide speed range [PDF]

, 2013
This paper presents a technique to modify the rotor lamination of a permanent-magnet-assisted synchronous reluctance motor, in order to reduce the magnet volume with no side effect on performance.
Guglielmi, Paolo, Pellegrino, Gian-Mario Luigi, Vagati, Alfredo, Armando, Eric Giacomo, PELLEGRINO, GIAN - MARIO LUIGI, Boazzo, Barbara   +5 more
core   +1 more source

Tumor Exposomics: A New Paradigm for Individualized Continuous Exposure Monitoring

Advanced Science, EarlyView.
Tumor exposomics integrates continuous monitoring of environmental exposures, endogenous biological responses, and behavioral factors within a unified temporal framework. By combining multimodal sensing technologies with AI‐enabled causal modeling, this emerging paradigm reconstructs exposure‐damage trajectories and supports individualized dynamic risk
Kaicheng Shen, Weiyi Wang, Yang Wang, Yiqiang Wu, Xiaohong Liu, Wei Zhang, Juanjuan Ou   +6 more
wiley   +1 more source

Combined two-stage total pancreatoduodenectomy and esophagectomy for synchronous malignancy of the pancreatic corpus and the esophagus: A surgical case report. [PDF]

Int J Surg Case Rep, 2023
Studier-Fischer A, Henriques V, Rheinheimer S, Salg GA, Nickel F, Schneider M.   +5 more
europepmc   +1 more source