Results 81 to 90 of about 355,526 (241)

Targeting the CRYAB/β‐Catenin Axis with an MMP‐9‐Responsive Hydrogel Disrupts CTC Clusters to Suppress Progression of Hepatocellular Carcinoma after Radiofrequency Ablation

Advanced Science, EarlyView.
The graphical abstract illustrates that sublethal thermal stress after iRFA upregulates the chaperone CRYAB in residual HCC cells, which stabilizes β‐catenin and drives a dual pathological program, including EMT and N2‐TAN polarization, thereby leading to heterotypic CTC cluster formation. The MMP‐9‐responsive hydrogel (XB@Gel) delivers XAV‐939 and BMS‐
Hui Chen, Danni Yang, Songying Pi, Yuhan Liu, Hongbin Huang, Feile Ye, Yuhong Lin, Zhongzhen Su, Yongquan Huang   +8 more
wiley   +1 more source

Reverse-Link Performance of Synchronous DS-CDMA Systems in Dispersive Rician Multipath Fading Channels

, 2003
The reverse-link performance of synchronous DS-CDMA is investigated in Rician multipath fading environments. The numerical results show that the performance benefits of synchronous transmission depend on the specular path’s power as well as on the ...
Hwang, S.H., Hanzo, L.
core   +1 more source

Small Cell Carcinoma of Gallbladder With Nodal Metastasis Mimicking As Synchronous Malignancy in Gallbladder and Common Bile Duct. [PDF]

Cureus, 2021
Naik N, Shaikh O, Sowmiya SV, Gaur NK, Balasubramanian G.   +4 more
europepmc   +1 more source

Impact of cross-saturation in sensorless control of transverse-laminated synchronous reluctance motors [PDF]

, 2006
Synchronous reluctance (SyR) motors are well suited to a zero-speed sensorless control, because of their inherently salient behavior. However, the cross-saturation effect can lead to large errors on the position estimate, which is based on the ...
Pastorelli, Michele Angelo, Guglielmi, Paolo, Vagati, Alfredo   +2 more
core   +1 more source

Ribonucleotides Amplify Mitochondrial DNA‐Driven cGAS–STING Activation via FdUMP‐ribonucleotide Hybrid Particles to Potentiate Chemoimmunotherapy

Advanced Science, EarlyView.
This work develops a metabolic sharing strategy that employs cytidine monophosphate (CMP) to competitively reprogram floxuridine (FUDR) pyrimidine metabolism in colorectal tumor cells. Elevated intracellular FdUMP induces nucleotide imbalance, drives mitochondrial DNA release and cGAS‐STING innate immune cascade activation, and potentiates robust ...
Chao Wang, Chenxuan Zhao, Yesong Yao, Zhiwen Zou, Anxin Shi, Zhuo Feng, Mingkang Yang, Yue Yu, Yang Liu, Xuehui Rui, Jinhui Wu   +10 more
wiley   +1 more source

Azacytidine plus olaparib for relapsed acute myeloid leukaemia, ineligible for intensive chemotherapy, diagnosed with a synchronous malignancy. [PDF]

J Cell Mol Med, 2021
Iluta S, Pasca S, Gafencu G, Jurj A, Terec A, Teodorescu P, Selicean C, Jitaru C, Preda A, Cenariu D, Constantinescu C, Iordache M, Tigu B, Munteanu R, Feder R, Dima D, Zdrenghea M, Gulei D, Ciuleanu TE, Tomuleasa C.   +19 more
europepmc   +1 more source

Position-sensorless control of permanent-magnet-assisted synchronous reluctance motor [PDF]

, 2003
The sensorless control of permanent-magnet-assisted synchronous reluctance (PMASR) motors is investigated, in order to conjugate the advantages of the sensorless control with full exploitation of the allowed operating area, for a given inverter.
Pastorelli, Michele Angelo, Pellegrino, Gian-Mario Luigi, Guglielmi, Paolo, Vagati, Alfredo, PELLEGRINO, GIAN - MARIO LUIGI   +4 more
core   +1 more source

Multifunctional Nanovaccine‐Radiotherapy Synergy Drives Anti‐Tumor Immunity via Multi‐Cascade Cell Death for Pancreatic Cancer Therapy

Advanced Science, EarlyView.
Machine‐learning‐driven transcriptomic analysis identifies FSTL3 as a key tumor‐microenvironment regulator in desmoplastic pancreatic adenocarcinoma. A cRGD‐modified liposome co‐loading gemcitabine and siFSTL3 serves as an irradiation‐triggered in situ nanovaccine. It synergizes with radiotherapy to induce ferroptosis and immunogenic cell death through
Chengyi Huang, Yushu Han, Xiang Liu, Chuanhao Wang, Xiaofei Zhu, Di Chen, Yangyang Gong, Liang Chen, Wenjuan Chen, Zhenyuan Miao, Bufu Tang, Huojun Zhang   +11 more
wiley   +1 more source

Synchronous adenocarcinomas of the colon presenting as synchronous colocolic intussusceptions in an adult

World Journal of Surgical Oncology, 2012
Intussusception is uncommon in adults. To our knowledge, synchronous colocolic intussusceptions have never been reported in the literature. Here we described the case of a 59-year-old female of synchronous colocolic intussusceptions presenting as acute ...
Chen Chuang-Wei, Lai Chieh-Wen, Hsiao Koung-Hong   +2 more
doaj   +1 more source

Upadacitinib Restrains the Pathogenic Fitness of CD4+ T Cells and Aberrant B Cell Programming in Optic Neuritis

Advanced Science, EarlyView.
Single‐cell profiling and functional perturbation reveal coordinated JAK1‐pSTAT3 downstream programs in optic neuritis, including MCL1‐dependent fitness of pathogenic CD4+ Tem cells and glycolysis‐linked, cholesterol‐sensitive B‐cell responses associated with RORA. Upadacitinib disrupts this reciprocal T‐B‐cell circuit and alleviates neuroinflammation,
Gengchen Jiang, Qi Jiang, Lian Han, Yue Peng, Xingyu Liu, Tong Yang, Hao Huang, Jiaying Liu, Yuan Gao, Hui Yang, Wenjun Zou, Zhaohuai Li, Wenru Su   +12 more
wiley   +1 more source