Results 271 to 280 of about 24,222,086 (313)
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Syndecan-1 in liver pathophysiology
American Journal of Physiology-Cell Physiology, 2022Syndecan-1 (SDC-1) is a heparan sulfate (HS)/chondroitin sulfate proteoglycan (PG) of the cell surface and the extracellular matrix (ECM), which regulates a broad spectrum of physiological and pathological processes such as cell proliferation, migration, inflammation, matrix remodeling, wound healing, and tumorigenesis. Syndecan-1 represents the major
Andrea Reszegi +4 more
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Mapping of matrix metalloproteinase cleavage sites on syndecan‐1 and syndecan‐4 ectodomains
FEBS Journal, 2013Syndecans are transmembrane heparan sulfate proteoglycans with roles in cell proliferation, differentiation, adhesion, and migration. They have been associated with multiple functions in tumour progression, through their ability to interact with a wide range of ligands as well as other receptors, which makes them key effectors in the pericellular ...
John R Couchman
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Syndecan-1 (CD138) as a pathogenesis factor and therapeutic target in breast cancer.
Current Medicinal Chemistry, 2021The successive stages of breast cancer growth and dissemination depend on cell-autonomous factors and the communication between tumor cells and their surrounding cellular and extracellular matrix microenvironment.
M. Sheta, M. Götte
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Syndecan-1 in B lymphoid malignancies
Annals of Hematology, 2002Syndecans are heparan sulfate-bearing proteoglycans that are found on the surface of most cells. Syndecan-1 is expressed predominantly on epithelia, but is also present on pre-B cells and plasma cells. The syndecans act to bind various effector molecules via their heparan sulfate chains, including both soluble and insoluble molecules within the ...
R D, Sanderson, M, Børset
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Impaired arteriogenesis in syndecan-1−/− mice
Journal of Surgical Research, 2015Collateral artery development (arteriogenesis) is an important compensatory response to arterial occlusion caused by atherosclerosis. The heparan sulfate proteoglycan syndecan-1 (sdc1) has previously been shown to affect the response to arterial injury but has yet been studied in arteriogenesis.
Gale L, Tang, Kevin, Weitz
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Syndecans and HIV-1 pathogenesis
Microbes and Infection, 2004The exploitation of receptors represents a common microbial strategy to survive in the hostile environment of the host. A growing body of evidence suggests that HIV-1 exploits a specific class of receptors-the syndecans-to facilitate colonization of the host.
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Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology, 2012
To construct the expressing vector pcDNA3.0- wildtype-syndecan-1(WT-sdc1) and pcDNA3.0-unshedding-syndecan-1(uS-sdc1), and to explore the expression in vitro.(1)The mouse WT-sdc1 DNA was successfully amplified by PCR and then cloned into pcDNA3.0. uS-sdc1 was construct by Gene splicing by overlap extension- PCR on the basis of WT-sdc1.
Jun, Liu +7 more
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To construct the expressing vector pcDNA3.0- wildtype-syndecan-1(WT-sdc1) and pcDNA3.0-unshedding-syndecan-1(uS-sdc1), and to explore the expression in vitro.(1)The mouse WT-sdc1 DNA was successfully amplified by PCR and then cloned into pcDNA3.0. uS-sdc1 was construct by Gene splicing by overlap extension- PCR on the basis of WT-sdc1.
Jun, Liu +7 more
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Chronic endometritis and reproductive failure: role of syndecan-1.
American Journal of Reproductive Immunology, 2020Chronic endometritis (CE) is an unusual inflammatory condition characterized by endometrial plasmacyte infiltration. It has a high prevalence in women with reproductive failure. Because of its characteristic localization patterns and molecular functions,
Yanhong Xu +4 more
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Syndecan-1 expression in laryngeal cancer
European Archives of Oto-Rhino-Laryngology, 2002Syndecan-1 is a member of the syndecan family of cell surface heparan sulphate proteoglycans. The aim of this study was the evaluation of syndecan-1 expression in laryngeal cancer. The findings were correlated both with the clinico-pathological parameters of the tumours and with patient survival.
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Syndecan-1 in the Tumor Microenvironment
2020Syndecan-1 along with the other three syndecan proteins is present in the varied components of the tumor microenvironment: fibroblasts, inflammatory tumor immunity-associated cells, vessels, and extracellular matrix. Epithelial and non-epithelial tumors may show stromal syndecans.
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