Results 1 to 10 of about 6,575 (136)

The Endothelial Glycocalyx: A Possible Therapeutic Target in Cardiovascular Disorders [PDF]

Frontiers in Cardiovascular Medicine, 2022
The physiological, anti-inflammatory, and anti-coagulant properties of endothelial cells (ECs) rely on a complex carbohydrate-rich layer covering the luminal surface of ECs, called the glycocalyx.
Anastasia Milusev, Anastasia Milusev, Robert Rieben, Nicoletta Sorvillo   +3 more
doaj   +3 more sources

The endothelial glycocalyx—All the same? No, it is not

Acute Medicine & Surgery, 2023
The endothelial glycocalyx covers the lumen of blood vessels throughout the body and plays an important role in endothelial homeostasis. Advances in electron microscopy techniques have provided clues to better understand the structure and composition of ...
Kodai Suzuki, Tomotaka Miura, Hideshi Okada   +2 more
doaj   +2 more sources

The Emerging Role of the Mammalian Glycocalyx in Functional Membrane Organization and Immune System Regulation

Frontiers in Cell and Developmental Biology, 2020
All cells in the human body are covered by a dense layer of sugars and the proteins and lipids to which they are attached, collectively termed the “glycocalyx.” For decades, the organization of the glycocalyx and its interplay with the cellular state ...
Leonhard Möckl
exaly   +3 more sources

Early Onset Preeclampsia Is Associated With Glycocalyx Degradation and Reduced Microvascular Perfusion

Journal of the American Heart Association, 2019
Background The endothelial glycocalyx is a vasoprotective barrier between the blood and endothelium. We hypothesized that glycocalyx degradation is present in preeclampsia, a pregnancy‐specific hypertensive disorder characterized by endothelial ...
Vesna D Garovic, Natasa M Milic, Karl A Nath   +2 more
exaly   +3 more sources

Factors Influencing Glycocalyx Degradation: A Narrative Review

Frontiers in Immunology
The glycocalyx is a layer of villus-like structure covering the luminal surface of vascular endothelial cells. Damage to the glycocalyx has been proven linked to the development of many diseases. However, the factors that promote damage to the glycocalyx
Lan Peng
exaly   +3 more sources

Effects of different dehydration methods on the preservation of aortic and renal glycocalyx structures in mice

Heliyon, 2023
Glycocalyx is located outside the vascular endothelial cells playing an important role in vascular homeostasis. However, lacking efficient detection methods is one of the biggest obstacles to study the glycocalyx. In this study, three dehydration methods
Zhi Li, Quanbin Zhang, Yuan-yuan Sun, Ning Wu   +3 more
doaj   +1 more source

Endothelial glycocalyx degradation during sepsis: Causes and consequences

Matrix Biology Plus, 2021
The glycocalyx is a ubiquitous structure found on endothelial cells that extends into the vascular lumen. It is enriched in proteoglycans, which are proteins attached to the glycosaminoglycans heparan sulfate, chondroitin sulfate, dermatan sulfate ...
Ryan C. Sullivan, Matthew D. Rockstrom, Eric P. Schmidt, Joseph A. Hippensteel   +3 more
doaj   +1 more source

Glycocalyx Impairment in Vascular Disease: Focus on Inflammation

Frontiers in Cell and Developmental Biology, 2021
The glycocalyx is a complex polysaccharide-protein layer lining the lumen of vascular endothelial cells. Changes in the structure and function of the glycocalyx promote an inflammatory response in blood vessels and play an important role in the ...
Jing Qu, Yue Cheng, Wenchao Wu, Lixing Yuan, Xiaojing Liu, Xiaojing Liu   +5 more
doaj   +1 more source

Endothelial Damage and the Microcirculation in Critical Illness

Biomedicines, 2022
Endothelial integrity maintains microcirculatory flow and tissue oxygen delivery. The endothelial glycocalyx is involved in cell signalling, coagulation and inflammation.
Rachael Cusack, Marc Leone, Alejandro H. Rodriguez, Ignacio Martin-Loeches   +3 more
doaj   +1 more source

Tetramethylpyrazine Alleviates Endothelial Glycocalyx Degradation and Promotes Glycocalyx Restoration via TLR4/NF-κB/HPSE1 Signaling Pathway During Inflammation

Frontiers in Pharmacology, 2022
Tetramethylpyrazine (TMP), a Chinese traditional herbal extraction widely used in treating cardiovascular diseases, could attenuate vascular endothelial injuries, but the underlying mechanism remains incomprehensive.
Jin Lei, Jin Lei, Peng Xiang, Peng Xiang, Shengmei Zeng, Shengmei Zeng, Le Chen, Le Chen, Lei Zhang, Lei Zhang, Zhiyi Yuan, Zhiyi Yuan, Jun Zhang, Jun Zhang, Tingting Wang, Tingting Wang, Ruihong Yu, Ruihong Yu, Wanping Zhang, Wanping Zhang, Issa Issoufou Ibrahim, Issa Issoufou Ibrahim, Limei Ma, Limei Ma, Chao Yu, Chao Yu   +25 more
doaj   +1 more source