The Endothelial Glycocalyx—All the Same? No, It Is Not
Acute Medicine & Surgery, 2023 The endothelial glycocalyx covers the lumen of blood vessels throughout the body and plays an important role in endothelial homeostasis. Advances in electron microscopy techniques have provided clues to better understand the structure and composition of ...
Hideshi Okada +2 more
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The Endothelial Glycocalyx: A Possible Therapeutic Target in Cardiovascular Disorders [PDF]
Frontiers in Cardiovascular Medicine, 2022 The physiological, anti-inflammatory, and anti-coagulant properties of endothelial cells (ECs) rely on a complex carbohydrate-rich layer covering the luminal surface of ECs, called the glycocalyx.
Robert Rieben, Anastasia Milusev
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Fluid shear stress-dependent modulation of the basal endothelial glycocalyx. [PDF]
PLoS ONEThe vascular endothelial glycocalyx is a major regulator of endothelium function, serving as a vital mechanotransducer and barrier. Shear stress due to blood flow exerted on the apical endothelial cell (EC) and glycocalyx have been the primary focus of ...
Zoe Vittum, Solomon A Mensah
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Sepsis-induced endothelial glycocalyx disruption and remodeling: an ultrastructural study in mice [PDF]
Intensive Care Medicine ExperimentalBackground Sepsis damages endothelial cells through glycocalyx degradation, contributing to organ dysfunction. Glycocalyx repair is essential for recovery, but the underlying mechanisms remain unclear. Rhamnan sulfate (RS), a sulfated polysaccharide with
Ryo Hisamune +10 more
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Endothelial glycocalyx glycan expression in lymphatic vasculature in mice [PDF]
Frontiers in Cell and Developmental BiologyLymphatic vessels are crucial for the drainage and transport of interstitial fluids, cells, and macromolecules. Like all other cells, lymphatic endothelial cells express a cell-surface glycocalyx, composed of carbohydrate-enriched molecules, that ...
Issahy Cano, Esak Lee
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Frontiers in Cell and Developmental BiologyThe endothelial glycocalyx encompasses the entire endothelial cell, transducing extracellular signals and regulating vascular permeability and barrier functions. The apical glycocalyx, which forms the lumen of the vessel, and the basal glycocalyx, at the
Solomon A Mensah
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Dynamic Changes in Endothelial Glycocalyx and Inflammatory Response in Patients with Acute Ischemic Stroke Treated with Mechanical Thrombectomy: Pathophysiological Aspects and Clinical Implications [PDF]
Neurology InternationalAcute ischemic stroke (AIS) is characterized by complex interactions among vascular occlusion, endothelial injury, and inflammatory activation, which collectively influence clinical outcomes. Increasing attention has focused on the endothelial glycocalyx,
Berya Günay +4 more
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Journal of the American Heart Association, 2019 Background The impairment of endothelium‐dependent vasodilation, increased endothelial permeability, and glycocalyx degradation are all important pathophysiological components of endothelial dysfunction.
Brygida Marczyk +2 more
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Porphyromonas gingivalis-derived outer membrane vesicles promote vascular endothelial glycocalyx injury via the PPAD/CitH3/B3GAT1 pathway [PDF]
Journal of NanobiotechnologyBackground The glycocalyx serves as the skeletal structure of the outer layer of endothelial cells and regulates the function of endothelial cells. Porphyromonas gingivalis (P. gingivalis) outer membrane vesicles (OMVs) exhibit the fundamental biological
Shoucheng Yin +9 more
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PET-microplastics trigger endothelial glycocalyx loss via ER stress and ROS unleashing IL-1β-driven SMC switching and early aortic structural impairment [PDF]
Journal of NanobiotechnologyPolyethylene terephthalate microplastics (PET-MPs), a major microplastics component identified in human vasculature, pose emerging environmental health risks.
Weixue Huo +7 more
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