Results 31 to 40 of about 377,666 (204)

Endothelial glycocalyx damage in kidney disease correlates with uraemic toxins and endothelial dysfunction

BMC Nephrology, 2021
Background Damage to the endothelial glycocalyx is an early indicator of vascular damage and a potential marker of endothelial dysfunction. This study aimed to assess the relationship between markers of glycocalyx damage, endothelial dysfunction, and ...
Hui Liew, Matthew A. Roberts, Alun Pope, Lawrence P. McMahon   +3 more
doaj   +1 more source

Endothelial Glycocalyx Degradation in Critical Illness and Injury

Frontiers in Medicine, 2022
The endothelial glycocalyx is a gel-like layer on the luminal side of blood vessels that is composed of glycosaminoglycans and the proteins that tether them to the plasma membrane.
Eric K. Patterson, Gediminas Cepinskas, Gediminas Cepinskas, Douglas D. Fraser, Douglas D. Fraser, Douglas D. Fraser, Douglas D. Fraser, Douglas D. Fraser   +7 more
doaj   +1 more source

Perioperative implication of the endothelial glycocalyx [PDF]

Korean Journal of Anesthesiology, 2018
The endothelial glycocalyx (EG) is a gel-like layer lining the luminal surface of healthy vascular endothelium. Recently, the EG has gained extensive interest as a crucial regulator of endothelial funtction, including vascular permeability, mechanotransduction, and the interaction between endothelial and circulating blood cells.
Jong Wook Song, Michael S. Goligorsky
openaire   +4 more sources

Endothelial Glycocalyx Integrity in Oncological Patients

International Journal of Cardiology, 2022
Background: Cancer is associated with early changes in the cardiovascular system (CV) before overt cardiotoxicity. Endothelial dysfunction is induced by chemotherapeutic regimens but there is no data for endothelial glycocalyx in cancer.<br><br>Methods: &nbsp;Sixty-four patients with cancer (65.6% with solid tumors and 34.4% with ...
KALLIOPI KERAMIDA, John Thymis, Maria Anastasiou, Konstantinos Katogiannis, Ioannis Kotsantis, Panagiota Economopoulou, Vasiliki Pappa, Panagiotis Tsirigotis, Vasiliki Bistola, Maria Thodi, Amanda Psyrri, Gerasimos Filippatos, Ignatios Ikonomidis   +12 more
openaire   +3 more sources

The endothelial glycocalyx in critical illness: A pediatric perspective

Matrix Biology Plus, 2022
The vascular endothelium is the interface between circulating blood and end organs and thus has a critical role in preserving organ function. The endothelium is lined by a glycan-rich glycocalyx that uniquely contributes to endothelial function through ...
Robert P. Richter, Gregory A. Payne, Namasivayam Ambalavanan, Amit Gaggar, Jillian R. Richter   +4 more
doaj   +1 more source

Heparinase selectively sheds heparan sulphate from the endothelial glycocalyx [PDF]

, 2008
A healthy vascular endothelium is coated by the endothelial glycocalyx. Its main constituents are transmembrane syndecans and bound heparan sulphates. This structure maintains the physiological endothelial permeability barrier and prevents leukocyte and ...
Rehm, Markus, Welsch, Ulrich, Jacob, Matthias, Chappell, Daniel, Conzen, Peter, Becker, Bernhard F., Stoeckelhuber, Mechthild   +6 more
core   +1 more source

The Structure and Function of the Glycocalyx and Its Connection With Blood-Brain Barrier

Frontiers in Cellular Neuroscience, 2021
The vascular endothelial glycocalyx is a dense, bush-like structure that is synthesized and secreted by endothelial cells and evenly distributed on the surface of vascular endothelial cells.
Jing Jin, Fuquan Fang, Wei Gao, Hanjian Chen, Jiali Wen, Xuehua Wen, Junfa Chen   +6 more
doaj   +1 more source

Three-dimensional ultrastructure of capillary endothelial glycocalyx under normal and experimental endotoxemic conditions

Critical Care, 2017
Background Sugar-protein glycocalyx coats healthy endothelium, but its ultrastructure is not well described. Our aim was to determine the three-dimensional ultrastructure of capillary endothelial glycocalyx in the heart, kidney, and liver, where ...
Hideshi Okada, Genzou Takemura, Kodai Suzuki, Kazumasa Oda, Chihiro Takada, Yasuaki Hotta, Nagisa Miyazaki, Akiko Tsujimoto, Isamu Muraki, Yoshiaki Ando, Ryogen Zaikokuji, Atsumu Matsumoto, Hiroki Kitagaki, Yuto Tamaoki, Takahiro Usui, Tomoaki Doi, Takahiro Yoshida, Shozo Yoshida, Hiroaki Ushikoshi, Izumi Toyoda, Shinji Ogura   +20 more
doaj   +1 more source

The Beneficial Effect of HES on Vascular Permeability and Its Relationship With Endothelial Glycocalyx and Intercellular Junction After Hemorrhagic Shock

Frontiers in Pharmacology, 2020
BackgroundVascular leakage is a common complication of hemorrhagic shock. Endothelial glycocalyx plays a crucial role in the protection of vascular endothelial barrier function.
Hongliang Zhao, Yu Zhu, Jie Zhang, Yue Wu, Xinming Xiang, Zisen Zhang, Tao Li, Liangming Liu   +7 more
doaj   +1 more source

Pro-atherosclerotic disturbed flow disrupts caveolin-1 expression, localization, and function via glycocalyx degradation

Journal of Translational Medicine, 2018
Background Endothelial-dependent atherosclerosis develops in a non-random pattern in regions of vessel bending and bifurcations, where blood flow exhibits disturbed flow (DF) patterns.
Ian C. Harding, Ronodeep Mitra, Solomon A. Mensah, Ira M. Herman, Eno E. Ebong   +4 more
doaj   +1 more source