Results 21 to 30 of about 377,666 (204)

A microscopic view on the renal endothelial glycocalyx

American Journal of Physiology-Renal Physiology, 2015
Item does not contain fulltextEndothelial cells perform key homeostatic functions such as regulating blood flow, permeability, and aiding immune surveillance for pathogens.
van der Vlag, Johan, Lee, D.H., Martijn J. C. Dane, Dae Hyun Lee, Margien G. S. Boels, Dane, M.J.C., Bernard M. van den Berg, Rabelink, T.J., Lee, Dae Hyun, Dane, Martijn J. C., Rabelink, Ton J., Zonneveld, A.J. van, Vink, Hans, Johan van der Vlag, M. Cristina Avramut, Boels, M.G.S., Tiemeier, Gesa L., Avramut, M. Cristina, Berg, B.M. van den, Avramut, M.C., Vlag, J. van der, Vink, H., Anton Jan van Zonneveld, Boels, M.G., Dane, M.J., Tiemeier, G.L., van Zonneveld, Anton Jan, Hans Vink, Gesa L. Tiemeier, Boels, Margien G. S., Ton J. Rabelink, van den Berg, Bernard M.   +31 more
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Endothelial Glycocalyx Impairment in Disease:Focus on Hyaluronan Shedding

The American journal of pathology, 2020
Hyaluronan (HA) is a ubiquitous glycosaminoglycan of the extracellular matrix. It is present in the endothelial glycocalyx covering the apical surface of endothelial cells.
Flamion, Bruno, Dogne, Sophie; id_orcid
core   +4 more sources

The Endothelial Glycocalyx [PDF]

Anesthesia & Analgesia, 2013
The endothelial glycocalyx is a dynamic layer of macromolecules at the luminal surface of vascular endothelium that is involved in fluid homeostasis and regulation. Its role in vascular permeability and edema formation is emerging but is still not well understood.
Stephen R. Collins, Randal S. Blank, Lindy S. Deatherage, Randal O. Dull   +3 more
openaire   +4 more sources

Endothelial glycocalyx degradation during sepsis: Causes and consequences

Matrix Biology Plus, 2021
The glycocalyx is a ubiquitous structure found on endothelial cells that extends into the vascular lumen. It is enriched in proteoglycans, which are proteins attached to the glycosaminoglycans heparan sulfate, chondroitin sulfate, dermatan sulfate ...
Ryan C. Sullivan, Matthew D. Rockstrom, Eric P. Schmidt, Joseph A. Hippensteel   +3 more
doaj   +1 more source

The Endothelial Glycocalyx and Neonatal Sepsis

International Journal of Molecular Sciences, 2022
Sepsis carries a substantial risk of morbidity and mortality in newborns, especially preterm-born neonates. Endothelial glycocalyx (eGC) is a carbohydrate-rich layer lining the vascular endothelium, with important vascular barrier function and cell adhesion properties, serving also as a mechano-sensor for blood flow.
Ahlam Fatmi, Wiam Saadi, Jesús Beltrán-García, José Luis García-Giménez, Federico V. Pallardó   +4 more
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Tetramethylpyrazine Alleviates Endothelial Glycocalyx Degradation and Promotes Glycocalyx Restoration via TLR4/NF-κB/HPSE1 Signaling Pathway During Inflammation

Frontiers in Pharmacology, 2022
Tetramethylpyrazine (TMP), a Chinese traditional herbal extraction widely used in treating cardiovascular diseases, could attenuate vascular endothelial injuries, but the underlying mechanism remains incomprehensive.
Jin Lei, Jin Lei, Peng Xiang, Peng Xiang, Shengmei Zeng, Shengmei Zeng, Le Chen, Le Chen, Lei Zhang, Lei Zhang, Zhiyi Yuan, Zhiyi Yuan, Jun Zhang, Jun Zhang, Tingting Wang, Tingting Wang, Ruihong Yu, Ruihong Yu, Wanping Zhang, Wanping Zhang, Issa Issoufou Ibrahim, Issa Issoufou Ibrahim, Limei Ma, Limei Ma, Chao Yu, Chao Yu   +25 more
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Visualising the endothelial glycocalyx in dogs

The Veterinary Journal, 2022
The endothelial glycocalyx (eGlx) lines the luminal surface of endothelial cells. It is critical in maintaining vascular health and when damaged contributes to many diseases. Its fragility makes studying the eGlx technically challenging. The current reference standard for eGlx visualisation, by electron microscopy using glutaraldehyde/Alcian blue ...
Lawrence-Mills, Sara, Neal, Chris R, Satchell, Simon C, Welsh, Gavin I, Foster, R R, Finch, Natalie C   +5 more
openaire   +4 more sources

Glycocalyx Impairment in Vascular Disease: Focus on Inflammation

Frontiers in Cell and Developmental Biology, 2021
The glycocalyx is a complex polysaccharide-protein layer lining the lumen of vascular endothelial cells. Changes in the structure and function of the glycocalyx promote an inflammatory response in blood vessels and play an important role in the ...
Jing Qu, Yue Cheng, Wenchao Wu, Lixing Yuan, Xiaojing Liu, Xiaojing Liu   +5 more
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A low molecular weight heparin inhibits experimental metastasis in mice independently of the endothelial glycocalyx. [PDF]

PLoS ONE, 2010
BACKGROUND: Some low molecular weight heparins (LMWHs) prolong survival of cancer patients and inhibit experimental metastasis. The underlying mechanisms are still not clear but it has been suggested that LMWHs (at least in part) limit metastasis by ...
Geerte L Van Sluis, Max Nieuwdorp, Pieter W Kamphuisen, Johan van der Vlag, Cornelis J F Van Noorden, C Arnold Spek   +5 more
doaj   +1 more source

Lectin Staining of Microvascular Glycocalyx in Microfluidic Cancer Cell Extravasation Assays

Life, 2021
The endothelial glycocalyx forms the inner-most lining of human microvasculature. It ensures the physiological function of blood vessels and plays a crucial role in the occurrence and progression of microvascular diseases.
Sebastian Beyer, Anna Blocki, Matthew Chung Yin Cheung, Zoe Ho Ying Wan, Babak Mehrjou, Roger Dale Kamm   +5 more
doaj   +1 more source