Results 21 to 30 of about 6,575 (136)
The glycocalyx: a novel diagnostic and therapeutic target in sepsis
Critical Care, 2019 The glycocalyx is a gel-like layer covering the luminal surface of vascular endothelial cells. It is comprised of membrane-attached proteoglycans, glycosaminoglycan chains, glycoproteins, and adherent plasma proteins. The glycocalyx maintains homeostasis
Ryo Uchimido +2 more
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The endothelial glycocalyx prefers albumin for evoking shear stress-induced, nitric oxide-mediated coronary dilatation [PDF]
, 2007 Background: Shear stress induces coronary dilatation via production of nitric oxide ( NO). This should involve the endothelial glycocalyx ( EG). A greater effect was expected of albumin versus hydroxyethyl starch ( HES) perfusion, because albumin seals ...
Rehm, Markus +7 more
core +1 more source
Critical Care, 2017 Background Sugar-protein glycocalyx coats healthy endothelium, but its ultrastructure is not well described. Our aim was to determine the three-dimensional ultrastructure of capillary endothelial glycocalyx in the heart, kidney, and liver, where ...
Hideshi Okada +20 more
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Setting the stage for universal pharmacological targeting of the glycocalyx
, 2023 All cells in the human body are covered by a complex meshwork of sugars as well as proteins and lipids to which these sugars are attached, collectively termed the glycocalyx.
Möckl, L., Almahayni, K.
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The glycocalyx as a permeability barrier: basic science and clinical evidence
Critical Care, 2022 Preclinical studies in animals and human clinical trials question whether the endothelial glycocalyx layer is a clinically important permeability barrier. Glycocalyx breakdown products in plasma mostly originate from 99.6–99.8% of the endothelial surface
Randal O. Dull, Robert G. Hahn
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Cells, 2022 Glycocalyx morphology was examined in the trabecular outflow pathway of monkey eyes with and without experimental glaucoma. Laser burns were administered along ~270 degrees of the trabecular meshwork (TM) of one eye (n = 6) or both eyes (n = 2) of each ...
Shayna Sosnowik +5 more
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A low molecular weight heparin inhibits experimental metastasis in mice independently of the endothelial glycocalyx. [PDF]
PLoS ONE, 2010 BACKGROUND: Some low molecular weight heparins (LMWHs) prolong survival of cancer patients and inhibit experimental metastasis. The underlying mechanisms are still not clear but it has been suggested that LMWHs (at least in part) limit metastasis by ...
Geerte L Van Sluis +5 more
doaj +1 more source
Neuraminadase’s role in glycocalyx shedding.
, 2022 Representative images and comparison of glycocalyx staining intensity shows that neuraminidase alone causes decreased glycocalyx staining intensity when compared to control human umbilical vein endothelial cells.
Olan Jackson-Weaver (11512962) +9 more
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Metalloproteinase inhibitors protect the glycocalyx.
, 2022 Representative images and comparison of glycocalyx staining intensity shows that glycocalyx staining intensity is preserved when H1N1 infection occurs in the presence of the metalloproteinase inhibitor marimastat for human umbilical vein endothelial ...
Olan Jackson-Weaver (11512962) +9 more
core +1 more source
Understanding the basic role of glycocalyx during cancer
Journal of Radiation and Cancer Research, 2016 Metastasis or cancer is a functional, molecular and structural disorder which has been an unsolved and fatal mystery and leads to death in most of the individuals suffering from it in spite of the advances made in biomedical and oncological fields ...
Yogendrakumar Harivansh Lahir
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