Characterization of wooden breast myopathy: a focus on syndecans and ECM remodeling [PDF]
Frontiers in Physiology, 2023 Introduction: The skeletal muscle deformity of commercial chickens (Gallus gallus), known as the wooden breast (WB), is associated with fibrotic myopathy of unknown etiology.
Lucie Pejšková +12 more
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Syndecans and Pancreatic Ductal Adenocarcinoma [PDF]
Biomolecules, 2021 Pancreatic Ductal Adenocarcinoma (PDAC) is a fatal disease with poor prognosis because patients rarely express symptoms in initial stages, which prevents early detection and diagnosis.
Nausika Betriu +3 more
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Specific structural features of syndecans and heparan sulfate chains are needed for cell signaling [PDF]
Brazilian Journal of Medical and Biological Research, 2006 The syndecans, heparan sulfate proteoglycans, are abundant molecules associated with the cell surface and extracellular matrix and consist of a protein core to which heparan sulfate chains are covalently attached. Each of the syndecan core proteins has a
C.C. Lopes, C.P. Dietrich, H.B. Nader
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Transport of CCL2 across an induced pluripotent stem cell-derived in vitro model of the human blood-brain barrier is heparan sulfate-dependent. [PDF]
PLoS ONETransport of immune-active substances across the blood-brain barrier (BBB) is an important mechanism of neuroimmune regulation. CCL2 is an exemplary chemokine that regulates neuroinflammation and can cross the intact BBB from blood to brain in mice. This
Lindsey M Williams +7 more
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Glycosaminoglycans are involved in pathogen adherence to corneal epithelial cells differently for Gram-positive and Gram-negative bacteria [PDF]
Frontiers in Cellular and Infection Microbiology, 2016 The epithelium of the cornea is continuously exposed to pathogens, and adhesion to epithelial cells is regarded as an essential first step in bacterial pathogenesis.
Beatriz García +15 more
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Syndecan 2 proteoglycan serves as a hepatitis B virus cell attachment receptor. [PDF]
J VirolTripathi SK, Li Y, Luo G.
europepmc +2 more sources
Syndecan receptors: pericellular regulators in development and inflammatory disease [PDF]
Open Biology, 2021 The syndecans are the major family of transmembrane proteoglycans, usually bearing multiple heparan sulfate chains. They are present on virtually all nucleated cells of vertebrates and are also present in invertebrates, indicative of a long evolutionary ...
Sandeep Gopal +4 more
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Syndecans in Alzheimer’s disease: pathogenetic mechanisms and potential therapeutic targets [PDF]
Neural Regeneration ResearchCarmela Rita Balistreri +1 more
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Shed syndecan-2 inhibits angiogenesis [PDF]
Journal of Cell Science, 2014 ABSTRACT Angiogenesis is essential for the development of a normal vasculature, tissue repair and reproduction, and also has roles in the progression of diseases such as cancer and rheumatoid arthritis. The heparan sulphate proteoglycan syndecan-2 is expressed on mesenchymal cells in the vasculature and, like the other members of its ...
Giulia De Rossi +6 more
openalex +7 more sources
Syndecan-2 is a novel target of insulin-like growth factor binding protein-3 and is over-expressed in fibrosis [PDF]
, 2012 Extracellular matrix deposition and tissue scarring characterize the process of fibrosis. Transforming growth factor beta (TGFβ) and Insulin-like growth factor binding protein-3 (IGFBP-3) have been implicated in the pathogenesis of fibrosis in various ...
Adriana T. Larregina +7 more
core +14 more sources