Results 111 to 120 of about 11,102 (261)

Differential structural remodelling of heparan sulfate by chemokines: the role of chemokine oligomerization [PDF]

, 2017
Chemokines control the migration of cells in normal physiological processes and in the context of disease such as inflammation, autoimmunity and cancer.
Dyer, DP, Handel, TM, Migliorini, E, Richter, RP, Salanga, CL, Thakar, D   +5 more
core   +4 more sources

Identification of SDC1 as a Key Regulator and Therapeutic Target in Rheumatoid Arthritis via JAK2‐STAT3 Pathway

International Journal of Rheumatic Diseases, Volume 29, Issue 2, February 2026.
ABSTRACT Introduction Rheumatoid arthritis (RA) is a chronic autoimmune disorder with unclear molecular mechanisms, complicating early diagnosis and treatment. This study aimed to identify hub genes and pathways driving RA pathogenesis and assess their therapeutic potential.
Gan Cao, Zhihui Wu, Yatao Du, Dongxue Dai, Yang Sun, Xi Jia, Huixin Cai   +6 more
wiley   +1 more source

Syndecans and glycosaminoglycans influence B-cell development and activation

EMBO Reports
Syndecans (SDCs) are glycosaminoglycan-containing cell surface proteins with diverse functions in the immune system with SDC1 (CD138) and SDC4 expressed in B-lineage cells.
Craig I McKenzie, Alexandra R Dvorscek, Zhoujie Ding, Marcus J Robinson, Kristy O’Donnell, Catherine Pitt, Daniel T Ferguson, Jesse Mulder, Marco J Herold, David M Tarlinton, Isaak Quast   +10 more
doaj   +1 more source

Heparan sulfate proteoglycan-dependent neutrophil chemotaxis toward PR-39 cathelicidin

Journal of Inflammation, 2006
Cathelicidins are mammalian proteins containing a C-terminal cationic antimicrobial domain. Porcine PR-39 cathelicidin affects leukocyte biology.
Patsch Josef R, Ricevuti Giovanni, Ross Christopher R, Kaneider Nicole C, Mosheimer Birgit, Djanani Angela, Wiedermann Christian J   +6 more
doaj   +1 more source

Erratum: The role and therapeutic value of syndecan-1 in cancer metastasis and drug resistance [PDF]

, 2022
Frontiers Production Office
openalex   +1 more source

A Novel Human Cellular System for Studying Normal Aging and for Anti‐Aging Discovery

Aging Cell, Volume 25, Issue 2, February 2026.
This study introduces a human cellular aging model using placental trophoblasts (hTSC‐STBs) that mimics key aging features like senescence and genomic instability. It aligns with human tissue aging and responds to anti‐aging treatments, offering a scalable platform to screen potential therapies and bridge lab findings to clinical applications ...
Zhen Feng, Cheuk Shuen Li, Haifeng Fu, Wenxin Jiang, Weiyu Zhang, Yingzhang Huang, Yunying Huang, Timothy Theodore Ka Ki Tam, Yang Li, Fang Liu, Liming Lu, Yin Lau Lee, William Shu Biu Yeung, Gordon Dougan, Pentao Liu   +14 more
wiley   +1 more source

Differential expression of ADAMTS -1, -4, -5 and TIMP -3 in rat spinal cord at different stages of acute experimental autoimmune encephalomyelitis [PDF]

, 2005
Experimental autoimmune encephalomyelitis (EAE) is an animal model of inflammatory demyelination, a pathological event common to multiple sclerosis (MS). During CNS inflammation there are alterations in the extracellular matrix (ECM).
A.K. Cross, Abbaszzade, Asher, Bandtlow, Barrett, Behi, Brew, Cal, Collins-Racie, D.J. Buttle, G. Haddock, Hartung, Hashimoto, Hill, Inatani, J. Plumb, J. Surr, Jaworski, Kashiwagi, Kashiwagi, Krekoski, Kuno, Kuno, Kurazono, Langton, Lindberg, Lo, Lukes, M.N. Woodroofe, Matthews, Muir, Novak, Novak, Ohgoh, Pangalos, Porter, R.A.D. Bunning, Rosenberg, Sandy, Sasaki, Satoh, Sobel, Somerville, Tang, Teesalu, Toft-Hansen, Vankemmelbeke, Vankemmelbeke, Vazquez, Yamaguchi, Yu, Yuan, Zuo   +52 more
core   +1 more source

Integrins' prime syndecan [PDF]

Science-Business eXchange, 2009
University of Wisconsin–Madison researchers have shown that synstatin, a syndecan-1–derived peptide, prevented angiogenesis and decreased tumor growth in mice. If the results translate to human cancers, synstatin or a mimetic may offer an alternative to integrin inhibitors in the clinic.
openaire   +1 more source

Research Progress of Exosome‐Derived microRNA in Alcohol Use Disorders: A Critical Review

Addiction Biology, Volume 31, Issue 2, February 2026.
Exosome‐derived microRNAs represent stable and mechanistically active mediators of alcohol‐induced multi‐organ injury. This review summarizes how chronic alcohol exposure reshapes exosomal miRNA cargo across the liver, immune system, and brain, highlighting key miRNAs with diagnostic value and therapeutic potential.
Bo Zhang, Ting ting Xie, Qiang Ma, Ya ping Jiang, Yu mei Wang   +4 more
wiley   +1 more source

Heparan Sulfate Regrowth Profiles Under Laminar Shear Flow Following Enzymatic Degradation [PDF]

, 2012
The local hemodynamic shear stress waveforms present in an artery dictate the endothelial cell phenotype. The observed decrease of the apical glycocalyx layer on the endothelium in atheroprone regions of the circulation suggests that the glycocalyx may ...
A Koo, A Remuzzi, AB Baker, AG Khan, Andrew Jia-An Koo, AW Gross, AW Mulivor, AW Mulivor, BM Berg van den, C. Forbes Dewey, CK Payne, D Chappell, DR Potter, EC Kennett, EE Ebong, G Dai, G Rao, G. Villarreal, Guillermo Garcia-Cardena, HH Lipowsky, I Shafat, I Vlodavsky, I Vlodavsky, IV Fuki, JA Florian, Jagadish Sankaran, JD Esko, Jennifer H. Shin, Jiro Sakai, KM Ainslie, KM Parmar, Kristina M. Giantsos-Adams, L Gao, M Nikmanesh, M Yanagishita, M. Gouverneur, ML Ballinger, MY Pahakis, NM Carter, P Zimmermann, R. O. Dull, RH Adamson, S Sarrazin, S. Reitsma, Sukhyun Song, T Arisaka, TR Rudd, V Ferro, X Bai, Y Takeuchi, Y Yao   +50 more
core   +3 more sources