Results 111 to 120 of about 10,821 (218)

Immunomodulatory Mechanisms of Chronic Wound Healing: Translational and Clinical Relevance

MedComm, Volume 6, Issue 11, November 2025.
This graphical abstract illustrates the immunomodulation of chronic wounds through various therapeutic approaches aimed at regulating the immune response to promote healing. ABSTRACT Chronic wounds—such as diabetic foot ulcers (DFUs), pressure ulcers (PUs), and venous leg ulcers (VLUs)—pose a serious clinical challenge due to their prolonged ...
Mahrukh Riaz, Muhammad Zohaib Iqbal, Agnes S. Klar, Thomas Biedermann   +3 more
wiley   +1 more source

Accentuating and opposing factors leading to development of thoracic aortic aneurysms not due to genetic or inherited conditions

Frontiers in Cardiovascular Medicine, 2015
Understanding and unraveling the pathophysiology of thoracic aortic aneurysm (TAA), a vascular disease with a potentially high mortality rate, is one of the next frontiers in vascular biology. The processes leading to the formation of TAA that are not of
Simon W Rabkin
doaj   +1 more source

Regulated Expression and Subcellular Localization of Syndecan Heparan Sulfate Proteoglycans and the Syndecan-Binding Protein CASK/LIN-2 during Rat Brain Development [PDF]

, 1999
Yi‐Ping Hsueh, Morgan Sheng
openalex   +1 more source

Supplementary Methods from Syndecan-Mediated Ligation of ECM Proteins Triggers Proliferative Arrest of Disseminated Tumor Cells

, 2023
Tsukasa Shibue, Ferenc Reinhardt, Robert A. Weinberg   +2 more
openalex   +1 more source

Comprehensive analysis of extracellular matrix remodelling via cyclophilin inhibition in human models of alcohol‐related liver fibrosis

British Journal of Pharmacology, Volume 182, Issue 22, Page 5647-5669, November 2025.
Background and Purpose Chronic liver disease and hepatic fibrosis constitute a threat to global health. Clinical translation of preclinical research has been limited, highlighting an urgent need for novel treatments. Cyclophilin inhibitors have shown beneficial effects in liver disease; however, the underlying mechanism of action and the effect across ...
Una Rastovic, Sara Campinoti, Lai Wei, Bruna Almeida, Sergio Francesco Bozzano, Ramin Amiri, Nicola Harris, Omolola Ajayi, Tsin Shue Koay, Caoimhe Kerins, Fiona N. Kenny, Ane Zamalloa, Lissette Adofina, Rosa Miquel, Yoh Zen, Parthi Srinivasan, Krishna Menon, Nigel Heaton, Camilla Luni, Eileen Gentleman, Tanya Shaw, Daren Ure, Shilpa Chokshi, Luca Urbani, Elena Palma   +24 more
wiley   +1 more source

Differential expression of ADAMTS -1, -4, -5 and TIMP -3 in rat spinal cord at different stages of acute experimental autoimmune encephalomyelitis [PDF]

, 2005
Experimental autoimmune encephalomyelitis (EAE) is an animal model of inflammatory demyelination, a pathological event common to multiple sclerosis (MS). During CNS inflammation there are alterations in the extracellular matrix (ECM).
A.K. Cross, Abbaszzade, Asher, Bandtlow, Barrett, Behi, Brew, Cal, Collins-Racie, D.J. Buttle, G. Haddock, Hartung, Hashimoto, Hill, Inatani, J. Plumb, J. Surr, Jaworski, Kashiwagi, Kashiwagi, Krekoski, Kuno, Kuno, Kurazono, Langton, Lindberg, Lo, Lukes, M.N. Woodroofe, Matthews, Muir, Novak, Novak, Ohgoh, Pangalos, Porter, R.A.D. Bunning, Rosenberg, Sandy, Sasaki, Satoh, Sobel, Somerville, Tang, Teesalu, Toft-Hansen, Vankemmelbeke, Vankemmelbeke, Vazquez, Yamaguchi, Yu, Yuan, Zuo   +52 more
core   +1 more source

Changes in microcirculation variables in an acute endotoxaemic equine model

Equine Veterinary Journal, Volume 57, Issue 6, Page 1623-1634, November 2025.
Abstract Background Microcirculation is the essential link between macrocirculation and cellular metabolism. Objectives To test our hypotheses that microcirculation variables will show a heterogeneous flow pattern during experimental endotoxaemia, and that fluid therapy and noradrenaline (NA) infusion will normalise altered microcirculation variables ...
Philipp K. Sauter, Barbara Steblaj, Sabine B. R. Kästner, Franz J. Söbbeler, Julia K. Reiners, Annette P. N. Kutter, Alvaro J. Gutiérrez Bautitsta, Stephan Neudeck   +7 more
wiley   +1 more source

Molecular targets and signaling pathways regulated by nuclear translocation of syndecan-1 [PDF]

, 2017
Tünde Szatmári, Filip Mundt, Ashish Kumar-Singh, Lena Möbus, Rita Ötvös, Anders Hjerpe, Katalin Dobra   +6 more
openalex   +1 more source

Heparan Sulfate Regrowth Profiles Under Laminar Shear Flow Following Enzymatic Degradation [PDF]

, 2012
The local hemodynamic shear stress waveforms present in an artery dictate the endothelial cell phenotype. The observed decrease of the apical glycocalyx layer on the endothelium in atheroprone regions of the circulation suggests that the glycocalyx may ...
A Koo, A Remuzzi, AB Baker, AG Khan, Andrew Jia-An Koo, AW Gross, AW Mulivor, AW Mulivor, BM Berg van den, C. Forbes Dewey, CK Payne, D Chappell, DR Potter, EC Kennett, EE Ebong, G Dai, G Rao, G. Villarreal, Guillermo Garcia-Cardena, HH Lipowsky, I Shafat, I Vlodavsky, I Vlodavsky, IV Fuki, JA Florian, Jagadish Sankaran, JD Esko, Jennifer H. Shin, Jiro Sakai, KM Ainslie, KM Parmar, Kristina M. Giantsos-Adams, L Gao, M Nikmanesh, M Yanagishita, M. Gouverneur, ML Ballinger, MY Pahakis, NM Carter, P Zimmermann, R. O. Dull, RH Adamson, S Sarrazin, S. Reitsma, Sukhyun Song, T Arisaka, TR Rudd, V Ferro, X Bai, Y Takeuchi, Y Yao   +50 more
core   +3 more sources

Tumor‐infiltrating immune cells predict the response to somatostatin receptor ligands only in somatotropinomas naïve to medical therapy

Journal of Neuroendocrinology, Volume 37, Issue 11, November 2025.
Abstract Tumor‐infiltrating immune cells (TICs) are important components of the tumor microenvironment (TME). They regulate somatotroph adenoma treatment responses to therapy with somatostatin receptor ligands (SRLs), mediated by soluble factors and cytokines. In this study, we assessed the effect of SRLs treatment on TICs.
Sabrina Chiloiro, Alessandra Vicari, Antonella Giampietro, Pier Paolo Mattogno, Natalia Cappoli, Greis Konini, Rosalinda Calandrelli, Liverana Lauretti, Simona Gaudino, Mario Rigante, Guido Rindi, Alessandro Olivi, Laura De Marinis, Antonio Bianchi, Francesco Doglietto, Marco Gessi, Alfredo Pontecorvi   +16 more
wiley   +1 more source