Specific structural features of syndecans and heparan sulfate chains are needed for cell signaling [PDF]
Brazilian Journal of Medical and Biological Research, 2006 The syndecans, heparan sulfate proteoglycans, are abundant molecules associated with the cell surface and extracellular matrix and consist of a protein core to which heparan sulfate chains are covalently attached. Each of the syndecan core proteins has a
C.C. Lopes, C.P. Dietrich, H.B. Nader
doaj +3 more sources
Glycosaminoglycans are involved in pathogen adherence to corneal epithelial cells differently for Gram-positive and Gram-negative bacteria [PDF]
Frontiers in Cellular and Infection Microbiology, 2016 The epithelium of the cornea is continuously exposed to pathogens, and adhesion to epithelial cells is regarded as an essential first step in bacterial pathogenesis.
Beatriz García +15 more
doaj +5 more sources
Syndecan-2 is a novel target of insulin-like growth factor binding protein-3 and is over-expressed in fibrosis [PDF]
, 2012 Extracellular matrix deposition and tissue scarring characterize the process of fibrosis. Transforming growth factor beta (TGFβ) and Insulin-like growth factor binding protein-3 (IGFBP-3) have been implicated in the pathogenesis of fibrosis in various ...
Adriana T. Larregina +7 more
core +14 more sources
Association Between Serum Syndecan 1 Levels and Metabolic Syndrome Parameters: A Comparative Cross-Sectional Study. [PDF]
Endocrinol Diabetes MetabThe results revealed that men in the MetS+ HTN+ ALT+ group had significantly higher serum SDC1 levels than women (20.19 ± 10.56 vs. 11.82 ± 5.09 ng/mL, p = 0.020). Furthermore, in both the total study sample and the MetS+ HTN+ ALT+ group, SDC1 concentrations were positively correlated with diastolic blood pressure (r = 0.256, p = 0.021; r = 0.463, p ...
Tavalaie S +9 more
europepmc +2 more sources
On Top of the Alveolar Epithelium: Surfactant and the Glycocalyx [PDF]
, 2020 Gas exchange in the lung takes place via the air-blood barrier in the septal walls of alveoli. The tissue elements that oxygen molecules have to cross are the alveolar epithelium, the interstitium and the capillary endothelium.
Hegermann, Jan +8 more
core +1 more source
Mechanotransmission of haemodynamic forces by the endothelial glycocalyx in a full-scale arterial model [PDF]
, 2019 The glycocalyx has been identified as a key mechano-sensor of the shear forces exerted by streaming blood onto the vascular endothelial lining.
Gallo, Diego +2 more
core +4 more sources
Heparinase selectively sheds heparan sulphate from the endothelial glycocalyx [PDF]
, 2008 A healthy vascular endothelium is coated by the endothelial glycocalyx. Its main constituents are transmembrane syndecans and bound heparan sulphates. This structure maintains the physiological endothelial permeability barrier and prevents leukocyte and ...
Becker, Bernhard F. +6 more
core +1 more source
Frontiers in Physiology, 2018 Syndecans belong to a four-member family of cell surface heparan sulfate proteoglycans (HSPGs) abundantly present in various tissues. They are primarily recognized as extracellular matrix (ECM) receptors able to bind various ECM components and form ...
Darko Kero +6 more
doaj +1 more source
The endothelial glycocalyx prefers albumin for evoking shear stress-induced, nitric oxide-mediated coronary dilatation [PDF]
, 2007 Background: Shear stress induces coronary dilatation via production of nitric oxide ( NO). This should involve the endothelial glycocalyx ( EG). A greater effect was expected of albumin versus hydroxyethyl starch ( HES) perfusion, because albumin seals ...
Bernhard F. Becker +25 more
core +1 more source
Syndecans as modulators and potential pharmacological targets in cancer progression
Frontiers in Oncology, 2014 Extracellular matrix (ECM) components form a dynamic network of key importance for cell function and properties. Key macromolecules in this interplay are syndecans (SDCs), a family of transmembrane heparan sulfate proteoglycans (HSPGs).
Despoina eBarbouri +5 more
doaj +1 more source