Results 21 to 30 of about 10,821 (218)
Identification of novel chondroitin proteoglycans in Caenorhabditis elegans: embryonic cell division depends on CPG-1 and CPG-2. [PDF]
, 2006 Vertebrates produce multiple chondroitin sulfate proteoglycans that play important roles in development and tissue mechanics. In the nematode Caenorhabditis elegans, the chondroitin chains lack sulfate but nevertheless play essential roles in embryonic ...
Bishop, Joseph R +4 more
core +2 more sources
mBio, 2020 Subversion of heparan sulfate proteoglycans (HSPGs) is thought to be a common virulence mechanism shared by many microbial pathogens. The prevailing assumption is that pathogens co-opt HSPGs as cell surface attachment receptors or as inhibitors of innate
Akiko Jinno +3 more
doaj +1 more source
The role of the host—Neutrophil biology
Periodontology 2000, EarlyView., 2023 Abstract Neutrophilic polymorphonuclear leukocytes (neutrophils) are myeloid cells packed with lysosomal granules (hence also called granulocytes) that contain a formidable antimicrobial arsenal. They are terminally differentiated cells that play a critical role in acute and chronic inflammation, as well as in the resolution of inflammation and wound ...
Iain L. C. Chapple +4 more
wiley +1 more source
Specific syndecan-1 domains regulate mesenchymal tumor cell adhesion, motility and migration. [PDF]
PLoS ONE, 2011 BackgroundSyndecans are proteoglycans whose core proteins have a short cytoplasmic domain, a transmembrane domain and a large N-terminal extracellular domain possessing glycosaminoglycan chains. Syndecans are involved in many important cellular processes.
Fang Zong +9 more
doaj +1 more source
A novel role for syndecan-3 in angiogenesis. [PDF]
, 2013 Syndecan-3 is one of the four members of the syndecan family of heparan sulphate proteoglycans and has been shown to interact with numerous growth factors via its heparan sulphate chains.
A Alexopoulou +32 more
core +3 more sources
BMC Genomics, 2006 Background The syndecans are the major family of transmembrane proteoglycans in animals and are known for multiple roles in cell interactions and growth factor signalling during development, inflammatory response, wound-repair and tumorigenesis. Although
Adams Josephine C, Chakravarti Ritu
doaj +1 more source
Syndecan expressions in the human amnion and chorionic plate
European Journal of Histochemistry, 2010 The syndecan family consists of four distinct membrane glycoproteins in mammals. Syndecans control cell proliferation, differentiation, adhesion and migration through participation in cell-cell interactions, anchorage of cells to the extracellular ...
T. Lorenzi +7 more
doaj +1 more source
Syntenin-knock out reduces exosome turnover and viral transduction
Scientific Reports, 2021 Exosomal transfers represent an important mode of intercellular communication. Syntenin is a small scaffold protein that, when binding ALIX, can direct endocytosed syndecans and syndecan cargo to budding endosomal membranes, supporting the formation of ...
Rudra Kashyap +11 more
doaj +1 more source
Expression and Role of Heparan Sulfated Proteoglycans in Pancreatic Cancer
Frontiers in Oncology, 2021 Pancreatic cancer is a lethal condition with poor outcomes and an increasing incidence. The unfavourable prognosis is due to the lack of early symptoms and consequent late diagnosis.
Simone Furini, Chiara Falciani
doaj +1 more source
Heparan Sulfate Proteoglycans and Viral Attachment: True Receptors or Adaptation Bias?
Viruses, 2019 Heparan sulfate proteoglycans (HSPG) are composed of unbranched, negatively charged heparan sulfate (HS) polysaccharides attached to a variety of cell surface or extracellular matrix proteins.
Valeria Cagno +3 more
doaj +1 more source