Results 21 to 30 of about 11,102 (261)

Syndecans as modulators and potential pharmacological targets in cancer progression

Frontiers in Oncology, 2014
Extracellular matrix (ECM) components form a dynamic network of key importance for cell function and properties. Key macromolecules in this interplay are syndecans (SDCs), a family of transmembrane heparan sulfate proteoglycans (HSPGs).
Despoina eBarbouri, Nikolaos eAfratis, Chrisostomi eGialeli, Demitrios H Vynios, Achilleas D Theocharis, Nikos eKaramanos   +5 more
doaj   +1 more source

Identification of novel chondroitin proteoglycans in Caenorhabditis elegans: embryonic cell division depends on CPG-1 and CPG-2. [PDF]

, 2006
Vertebrates produce multiple chondroitin sulfate proteoglycans that play important roles in development and tissue mechanics. In the nematode Caenorhabditis elegans, the chondroitin chains lack sulfate but nevertheless play essential roles in embryonic ...
Bishop, Joseph R, Esko, Jeffrey D, Oegema, Karen, Olson, Sara K, Yates, John R   +4 more
core   +2 more sources

Syndecan-1 Promotes Streptococcus pneumoniae Corneal Infection by Facilitating the Assembly of Adhesive Fibronectin Fibrils

mBio, 2020
Subversion of heparan sulfate proteoglycans (HSPGs) is thought to be a common virulence mechanism shared by many microbial pathogens. The prevailing assumption is that pathogens co-opt HSPGs as cell surface attachment receptors or as inhibitors of innate
Akiko Jinno, Atsuko Hayashida, Howard F. Jenkinson, Pyong Woo Park   +3 more
doaj   +1 more source

Specific syndecan-1 domains regulate mesenchymal tumor cell adhesion, motility and migration. [PDF]

PLoS ONE, 2011
BackgroundSyndecans are proteoglycans whose core proteins have a short cytoplasmic domain, a transmembrane domain and a large N-terminal extracellular domain possessing glycosaminoglycan chains. Syndecans are involved in many important cellular processes.
Fang Zong, Eleni Fthenou, Filip Mundt, Tünde Szatmári, Ilona Kovalszky, László Szilák, David Brodin, George Tzanakakis, Anders Hjerpe, Katalin Dobra   +9 more
doaj   +1 more source

A novel role for syndecan-3 in angiogenesis. [PDF]

, 2013
Syndecan-3 is one of the four members of the syndecan family of heparan sulphate proteoglycans and has been shown to interact with numerous growth factors via its heparan sulphate chains.
A Alexopoulou, A Chui, A Chung, A Passaniti, A Pisconti, A Rapraeger, A Rapraeger, C Dealy, C Streuli, D Beauvais, D Cornelison, G De Rossi, G De Rossi, J Chen, J Couchman, J Couchman, J Couchman, J Creemers, J Whiteford, J Whiteford, J Whiteford, M Bespalov, M Chernousov, M Holderfield, M Potente, O Reizes, P Carmeliet, Q Zheng, R Kosher, R Nicosia, R Nolo, S Weis, V Asundi   +32 more
core   +3 more sources

Comparative genomics of the syndecans defines an ancestral genomic context associated with matrilins in vertebrates

BMC Genomics, 2006
Background The syndecans are the major family of transmembrane proteoglycans in animals and are known for multiple roles in cell interactions and growth factor signalling during development, inflammatory response, wound-repair and tumorigenesis. Although
Adams Josephine C, Chakravarti Ritu
doaj   +1 more source

Heparan Sulfate Proteoglycans and Viral Attachment: True Receptors or Adaptation Bias?

Viruses, 2019
Heparan sulfate proteoglycans (HSPG) are composed of unbranched, negatively charged heparan sulfate (HS) polysaccharides attached to a variety of cell surface or extracellular matrix proteins.
Valeria Cagno, Eirini D. Tseligka, Samuel T. Jones, Caroline Tapparel   +3 more
doaj   +1 more source

Syndecan expressions in the human amnion and chorionic plate

European Journal of Histochemistry, 2010
The syndecan family consists of four distinct membrane glycoproteins in mammals. Syndecans control cell proliferation, differentiation, adhesion and migration through participation in cell-cell interactions, anchorage of cells to the extracellular ...
T. Lorenzi, A. Turi, C. Crescimanno, M. Morroni, M. Castellucci, G. David, A. L. Tranquilli, D. Marzioni   +7 more
doaj   +1 more source

Heparan sulfate proteoglycans undergo differential expression alterations in left sided colorectal cancer, depending on their metastatic character [PDF]

, 2018
Background Heparan sulfate proteoglycans (HSPGs) are complex molecules which play a role in the invasion and growth and metastatic properties of cancerous cells.
Castañón de la Torre, Sonia, Crespo Susperregui, Ainara, Fernández Vega, Iván, García Fernández, Beatriz, García Suárez, Olivia, Quirós Fernández, Luis Manuel, Solis Hernández, María Pilar   +6 more
core   +2 more sources

The Cardiac Syndecan-2 Interactome [PDF]

Frontiers in Cell and Developmental Biology, 2020
The extracellular matrix (ECM) is important in cardiac remodeling and syndecans have gained increased interest in this process due to their ability to convert changes in the ECM to cell signaling. In particular, syndecan-4 has been shown to be important for cardiac remodeling, whereas the role of its close relative syndecan-2 is largely unknown in the ...
Sabrina Bech Mathiesen, Marianne Lunde, Maria Stensland, Marita Martinsen, Tuula A. Nyman, Geir Christensen, Geir Christensen, Cathrine Rein Carlson   +7 more
openaire   +4 more sources