Results 41 to 50 of about 11,102 (261)
Hypertension, 2010 Cardiac fibrosis is characterized by net accumulation of extracellular matrix in the myocardium and is an integral component of most cardiac pathological conditions. Fibrotic remodeling of the ventricle has profound consequences on cardiac function. Increased deposition of interstitial collagen in the perimysial space is initially associated with a ...
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Versican splice variant messenger RNA expression in normal human Achilles tendon and tendinopathies [PDF]
, 2004 Versican is the principal large proteoglycan expressed in mid-tendon, but its role in tendon pathology is unknown. Our objective was to define the expression of versican isoform splice variant messenger ribonucleic acid (mRNA) in normal Achilles tendons,
Corps, AN +6 more
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Cancer Treatment and Research Communications, 2021 While our understanding of tumors and how to treat them has advanced significantly since the days of Aminopterin and the radical mastectomy, cancer remains among the leading causes of death worldwide.
Daniel Czarnowski
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Osteoprotegerin Contributes to the Metastatic Potential of Cells with a Dysfunctional TSC2 Tumor-Suppressor Gene [PDF]
, 1974 In addition to its effects on bone metabolism, osteoprotegerin (OPG), a soluble member of the tumor necrosis factor family of receptors, promotes smooth muscle cell proliferation and migration and may act as a survival factor for tumor cells.
Steagall, Wendy K. +6 more
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Circulation Research, 2005 Cell-associated proteoglycans provide highly complex and sophisticated systems to control interactions of extracellular cell matrix components and soluble ligands with the cell surface. Syndecans, a conserved family of heparan- and chondroitin-sulfate carrying transmembrane proteins, are emerging as central players in these interactions. Recent studies
Eugene, Tkachenko +2 more
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Wooden breast myopathy is characterized by satellite cell dysfunction and syndecan-4 shedding
Frontiers in PhysiologyIntroductionSkeletal muscle satellite cells (MuSCs or stem cells) play a crucial role in muscle development, maintenance, and regeneration, supporting both hypertrophy and regenerative myogenesis.
Lucie Pejšková +9 more
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Human Genomics, 2020 Multiple sclerosis (MS) is a chronic inflammatory demyelinating disease affecting the central nervous system in young adults. Heparan sulfate proteoglycans (HSPGs) are ubiquitous to the cell surface and the extracellular matrix.
Rachel K. Okolicsanyi +4 more
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Syndecan-1 and Syndecan-4 Are Independent Indicators in Breast Carcinoma [PDF]
Journal of Histochemistry & Cytochemistry, 2011 Syndecan proteoglycans may be key regulators of tumor invasion and metastasis because this four-member family of transmembrane receptors regulates cell adhesion, proliferation, and differentiation. Their expression can also serve as prognostic markers.
Lendorf, Maria E +4 more
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Endothelial Cell Behavior Is Determined by Receptor Clustering Induced by Thrombospondin-1
Frontiers in Cell and Developmental Biology, 2021 The thrombospondins (TSPs) are a family of multimeric extracellular matrix proteins that dynamically regulate cellular behavior and response to stimuli.
Verônica Morandi +2 more
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Bioprinting Organs—Science or Fiction?—A Review From Students to Students
Advanced Healthcare Materials, EarlyView.Bioprinting artificial organs has the potential to revolutionize the medical field. This is a comprehensive review of the bioprinting workflow delving into the latest advancements in bioinks, materials and bioprinting techniques, exploring the critical stages of tissue maturation and functionality.
Nicoletta Murenu +18 more
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